WangYWangLZhuY, et al.Human brain organoid-on-a-chip to model prenatal nicotine exposure. Lab Chip2018; 18: 851–860.
3.
BlundellCYiYSMaL, et al.Placental drug transport-on-a-chip: a microengineered in vitro model of transporter-mediated drug efflux in the human placental barrier. Adv Healthc Mater2018; 7. DOI: 10.1002/adhm.201700786.
4.
ClercPLipnickSWillettC. A look into the future of ALS research. Drug Discov Today2016; 21: 939–949.
5.
BauerSWennberg HuldtCKanebrattKP, et al.Functional coupling of human pancreatic islets and liver spheroids on-a-chip: towards a novel human ex vivo type 2 diabetes model. Sci Rep2017; 7: 14620. Erratum in: Sci Rep 2018; 8: 1672.
6.
LangleyGRAdcockIMBusquetF, et al.Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations. Drug Discov Today2017; 22: 327–339.
7.
PoliniADel MercatoLLBarraA, et al.Towards the development of human immune-system-on-a-chip platforms. Drug Discov Today2019; 24: 517–525.
8.
Prantil-BaunRNovakRDasD, et al.Physiologically based pharmacokinetic and pharmacodynamic analysis enabled by microfluidically linked organs-on-chips. Annu Rev Pharmacol Toxicol2018; 58: 37–64.
9.
MaozBMHerlandAFitzGeraldEA, et al.A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nat Biotechnol2018; 36: 865–874.
10.
McAleerCWPointonALongCJ, et al.On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships. Sci Rep2019; 9: 9619.
11.
MarshallLJAustinCPCaseyW, et al.Recommendations toward a human pathway-based approach to disease research. Drug Discov Today2018; 23: 1824–1832.
12.
TriunfolMRehenSSimianM, et al.Human-specific approaches to brain research for the 21st century: a South American perspective. Drug Discov Today2018; 23: 1929–1935.
13.
EwartLDehneEMFabreK, et al.Application of microphysiological systems to enhance safety assessment in drug discovery. Annu Rev Pharmacol Toxicol2018; 58: 65–82.
14.
WolfensohnS. A review of the contributions of cross-discipline collaborative European IMI/EFPIA research projects to the development of Replacement, Reduction and Refinement strategies. Altern Lab Anim2018; 46: 91–102.
15.
SutherlandMLFabreKMTagleDA. The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline. Stem Cell Res Ther2013; 4 (Suppl. 1): I1.
16.
PohostGMElgavishGAEvanochkoWT. Nuclear magnetic resonance imaging: with or without nuclear?J Am Coll Cardiol1986; 7: 709–710.
17.
RussellWMSBurchRL. The principles of humane experimental technique. London: Methuen, 1959, 238 pp.
NCad. Transition to non-animal research: On opportunities for the phasing out of animal procedures and the stimulation of innovation without laboratory animals. Opinion of the Netherlands National Committee for the protection of animals used for scientific purposes (NCad). The Hague: Netherlands National Committee for the protection of animals used for scientific purposes (NCad), 2016, 76 pp.