Read-across for Hazard Assessment: The Ugly Duckling is Growing Up

ECHA (2015). Read-Across Assessment Framework (RAAF) [ECHA-15-R-07-EN], 38pp. Helsinki, Finland: European Chemicals Agency. Available at: http://echa.europa.eu/documents/10162/13628/raaf_en.pdf (Accessed 11.11.15).

Russell W.M.S. & Burch R.L. (1959). The Principles of Humane Experimental Technique, 238pp. London, UK: Methuen. Available online: http://altweb.jhsph.edu/pubs/books/humane_exp/het-toc

Berggren E. , Amcoff P. , Benigni R. , Blackburn K. , Carney E. , Cronin M. , Deluyker H. , Gautier F. , Judson R.S. , Kass G.E.N. , Keller D. , Knight D. , Lilienblum W. , Mahony C. , Rusyn I. , Schultz T. , Schwarz M. , Schüürmann G. , White A. , Burton J. , Lostia A.M. , Munn S. & Worth A. (2015). Chemical safety assessment using read-across: Assessing the use of novel testing methods to strengthen the evidence base for decision making. Environmental Health Perspectives, E-pub ahead of print [doi: 10.1289/ ehp.1409342].

Worth A. , Barroso J. , Bremer S. , Burton J. , Casati S. , Coecke S. , Corvi R. , Desprez B. , Dumont C. , Gouliarmou V. , Goumenou M. , Gräpel R. , Griesinger C. , Halder M. , Janusch Roi A. , Kienzler A. , Madia F. , Munn S. , Nepelska M. , Paini A. , Price A. , Prieto P. , Rolaki A. , Schäffer M. , Triebe J. , Whelan M. , Wittwehr C. & Zuang V. (2014). Alternative Methods for Regulatory Toxicology – A State-of-the-art review. Report EUR 26797 EN, 461pp. Ispra, Italy: European Commission, Joint Research Centre, Institute for Health and Consumer Protection. Available at: http://echa.europa.eu/documents/10162/13634/echa_jrc_sla_report_en.pdf (Accessed 11.11.15).

Cronin M.T. , Madden J. , Enoch S.J. , & Roberts D.W. (2013). Chemical Toxicity Prediction: Category Formation and Read-across, 191pp. London, UK: Royal Society of Chemistry.

Rovida C. , Alépée N. , Api A.M. , Basketter D.A. , Bois F.Y. , Caloni F. , Corsini E. , Daneshian M. , Eskes C. , Ezendam J. , Fuchs H. , Hayden P. , Hegele-Hartung C. , Hoffmann S. , Hubesch B. , Jacobs M.N. , Jaworska J. , Kleensang A. , Kleinstreuer N. , Lalko J. , Landsiedel R. , Lebreux F. , Luechtefeld T. , Locatelli M. , Mehling A. , Natsch A. , Pitchford J.W. , Prater D. , Prieto P. , Schepky A. , Schüürmann G. , Smirnova L. , Toole C. , van Vliet E. , Weisensee D. & Hartung T. (2015). Integrated Testing Strategies (ITS) for safety assessment. ALTEX 32, 25–40.

Willett C. , Caverly Rae J. , Goyak K.O. , Minsavage G. , Westmoreland C. , Andersen M. , Avigan M. , Duché D. , Harris G. , Hartung T. , Jaeschke H. , Kleensang A. , Landesmann B. , Martos S. , Matevia M. , Toole C. , Rowan A. , Schultz T. , Seed J. , Senior J. , Shah I. , Subramanian K. , Vinken M. & Watkins P. (2013). Building shared experience to advance practical application of pathway-based toxicology: Liver toxicity mode-of-action. ALTEX 31, 500–519.

Anon. (2007). Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Official Journal of the European Union L136, 29.05.2007, 3-280.

ECHA (2014). The Use of Alternatives to Testing on Animals for the REACH Regulation: Second Report under Article 117(3) of the REACH Regulation [ECHA-14-A-07-EN], 131pp. Helsinki, Finland: European Chemicals Agency. Available at: http://echa.europa.eu/documents/10162/13639/alternatives_test_animals_2014_en.pdf (Accessed 11.11.15).

Ball N. , Bartels M. , Budinsky R. , Klapacz J. , Hays S. , Kirman C. & Patlewicz G. (2014). The challenge of using read-across within the EU REACH regulatory framework; how much uncertainty is too much? Dipropylene glycol methyl ether acetate, an exemplary case study. Regulatory Toxicolology & Pharmacology 68, 212-221.

Schultz T.W. , Amcoff P. , Berggren E. , Gautier F. , Klaric M. , Knight D.J. , Mahony C. , Schwarz M. , White A. & Cronin M.T.D. (2015). A strategy for structuring and reporting a read-across prediction of toxicity. Regulatory Toxicology & Pharmacology 72, 586-601.

van Ravenzwaay B. , Herold M. , Kamp H. , Kapp M.D. , Fabian E. , Looser R. , Krennrich G. , Mellert W. , Prokoudine A. , Strauss V. , Walk T. & Wiemer J. (2012). Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals – from QSAR to QBAR. Mutation Research 746, 144-150.

Hagen M. , Pabel U. , Landsiedel R. , Bartsch I. , Falany C.N. , & Glatt H. (1998). Expression of human estrogen sulfotransferase in Salmonella typhimurium: Differences between hHST and hEST in the enantioselective activation of 1-hydroxyethylpyrene to a mutagen. Chemico-Biological Interactions 109, 249-253.

Brenna E. , Fuganti C. & Serra S. (2003). Enantioselective perception of chiral odorants. Tetrahedron: Asymmetry 14, 1-42.

Roberts D.W. , Aptula A.O. , Patlewicz G. , & Pease C. (2008). Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential. Journal of Applied Toxicology 28, 443-454.

Teubner W. , Mehling A. , Schuster P.X. , Guth K. , Worth A. , Burton J. , van Ravenzwaay B. & Landsiedel R. (2013). Computer models versus reality: How well do in silico models currently predict the sensitization potential of a substance. Regulatory Toxicology & Pharmacology 67, 468-485.

Urbisch D. , Mehling A. , Guth K. , Ramirez T. , Honarvar N. , Kolle S. , Landsiedel R. , Jaworska J. , Kern P.S. , Gerberick F. , Natsch A. , Emter R. , Ashikaga T. , Miyazawa M. & Sakaguchi H. (2015). Assessing skin sensitization hazard in mice and men using non-animal test methods. Regulatory Toxicology & Pharmacology 71, 337-351.

Hendren C.O. , Lowry G.V. , Unrine J.M. , & Wiesner M.R. (2015). A functional assay-based strategy for nanomaterial risk forecasting. Science of the Total Environment 536, 1029-1037.

Arts J.H. , Hadi M. , Irfan M.A. , Keene A.M. , Kreiling R. , Lyon D. , Maier M. , Michel K. , Petry T. , Sauer U.G. , Warheit D. , Wiench K. , Wohlleben W. & Landsiedel R. (2015). A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping). Regulatory Toxicology & Pharmacology 71, Suppl. 2, S1-S27.

Oomen A.G. , Bos P.M. , Fernandes T.F. , Hund-Rinke K. , Boraschi D. , Byrne H.J. , Aschberger K. , Gottardo S. , von der Kammer F. , Kühnel D. , Hristozov D. , Marcomini A. , Migliore L. , Scott-Fordsmand J. , Wick P. & Land siedel R. (2014). Concern-driven integrated approaches to nanomaterial testing and assessment – Report of the NanoSafety Cluster Working Group 10. Nanotoxicology 8, 334–348.

ECHA (2008). Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.6: QSARs and grouping of chemicals, 134pp. Helsinki, Finland: European Chemicals Agency. Available at: https://echa.europa.eu/documents/10162/13632/information_requirements_r6_en.pdf (Accessed 12.11.15).

ECHA (2012). Practical Guide 6 – How to report read-across and categories [ECHA-10-B-11.1-EN], 32pp. Helsinki, Finland: European Chemicals Agency. Available at: http://echa.europa.eu/documents/10162/13655/pg_report_readacross_en.pdf (Accessed 12.11.15).

ECHA (2013). Grouping of Substances and Read-across Approach – An illustrative example [ECHA-13-R-02-EN], 11pp. Helsinki, Finland: European Chemicals Agency. Available at: http://echa.europa.eu/documents/10162/13628/read_across_introductory_note_en.pdf (Accessed 12.11.15).

Patlewicz G. , Ball N. , Becker R.A. , Booth E.D. , Cronin M.T. , Kroese D. , Steup D. , van Ravenzwaay B. & Hartung T. (2014). Food for Thought: Read-across approaches – misconceptions, promises and challenges ahead. ALTEX 31, 387-396.

Patlewicz G. , Ball N. , Boogaard P.J. , Becker R.A. & Hubesch B. (2015). Building scientific confidence in the development and evaluation of read-across. Regulatory Toxicology & Pharmacology 72, 117-133.

OECD (undated). The OECD QSAR toolbox. Paris, France: Organisation for Economic Co-operation & Development. Available at: http://www.oecd.org/chemicalsafety/risk-assessment/theoecdqsartool-box.htm (Accessed 12.11.15).

OECD (undated). The Global Portal to Information on Chemical Substances (eChemPortal). Paris, France: Organisation for Economic Co-operation & Development. Available at: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en (Accessed 12.11.15).

OECD (2014). Series on Testing and Assessment No. 194: Guidance on Grouping of Chemicals, 2nd edition, ENV/JM/MONO(2014)4, 141pp. Paris, France: Organisation for Economic Co-operation & Development.

ECHA (undated). Registered substances. Helsinki, Finland: European Chemicals Agency. Available at: http://echa. europa.eu/information-on-chemicals/registered-substances (Accessed 12.11.15).

SEURAT (undated). Welcome to the SEURAT-1 website. Available at: http://www.seurat-1.eu/ (Accessed 11.11. 15).

EPA (2015). Toxicity Forecasting: Advancing the Next Generation of Chemical Evaluation. Durham, NC, USA: US EPA Research. Available at: http://www2.epa.gov/chemical-research/toxicity-forecasting (Accessed 12.11. 15).