A number of three-dimensional in vitro models are now available, but significant further developments are needed before their routine and widespread use as alternatives to animal testing will be possible
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References
1.
ThomasJ.A. (1970). Organ Culture, 512pp. New York, NY, USA: Academic Press.
2.
AntoniD., BurckelH., JossetE. & NoelG. (2015). Three-dimensional cell culture: A breakthrough in vivo. International Journal of Molecular Sciences16, 5517–5527.
3.
MatTek (2015). In Vitro Tissue Models. Ashland, MA, USA: MatTek Corporation. Available at: http://www.mattek.com/ (Accessed 30.07.15).
HeinonenT. (2015). Better science with human cell-based organ and tissue models. ATLA43, 29–38.
6.
JaminA.Sr, (2015). Predicting respiratory toxicity using a human 3D airway (EpiAirway™) model combined with multiple parametric analysis. Applied In Vitro Toxicology1, 55–65.
7.
Anon. (2015). Globally Harmonised System of Classification and Labelling of Chemicals. [In Japanese.] Tokyo, Japan: Ministry of Health, Labour & Welfare. Available at: http://anzeninfo.mhlw.go.jp/user/anzen/kag/ankg_ghs.htm (Accessed 30.07.15).
US FDA (2012). Guidance for Industry Drug Interaction Studies – Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations: Draft Guidance, 79pp. Silver Spring, MD, USA: US Department of Health and Human Services, Food and Drug Administration. Available at: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm292362.pdf (Accessed 30.07.15).
15.
EMA (2012). Guideline on the Investigation of Drug Interactions, 59pp. London, UK: European Medicines Agency.