Microfluidic technologies permit the replication in vitro of geometrical features essential for the homeostasis of all vascularised tissues in vivo, including the contribution of pericytes to the endothelial barrier
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References
1.
ArmulikA., GenovéG. & BetsholtzC. (2011). Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises. Developmental Cell21, 193–215.
AguileraK.Y. & BrekkenR.A. (2014). Recruitment and retention: Factors that affect pericyte migration. Cellular & Molecular Life Sciences71, 299–309.
5.
StarkK., EckartA., HaidariS., TirniceriuA., LorenzM., von BrühlM.L., GärtnerF., KhandogaA.G., LegateK.R., PlessR., HepperI., LauberK., WalzogB. & MassbergS. (2013). Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and ‘instruct’ them with pattern-recognition and motility programs. Nature Immunology14, 41–51.
6.
JohnsonJ.R., FolestadE., RowleyJ.E., NollE.M., WalkerS.A., LloydC.M., RankinS.M., PietrasK., ErikssonU. & FuxeJ. (2015). Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma. American Journal of Physiology. Lung Cellular & Molecular Physiology308, L658–L671.
7.
BaiY., ZhuX., ChaoJ., ZhangY., QianC., LiP., LiuD., HanB., ZhaoL., ZhangJ., BuchS., TengG., HuG. & YaoH. (2015). Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGF expression: Implications for stroke. PLoS One10, e0124362.
8.
da SilvaM.L., CaplanA.I. & NardiN.B. (2008). In search of the in vivo identity of mesenchymal stem cells. Stem Cells26, 2287–2299.
9.
CrisanM., YapS., CasteillaL., ChenC.W., CorselliM., ParkT.S., AndrioloG., SunB., ZhengB., ZhangL., NorotteC., TengP.N., TraasJ., SchugarR., DeasyB.M., BadylakS., BuhringH.J., GiacobinoJ.P., LazzariL., HuardJ. & PéaultB. (2008). A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell3, 301–313.
TidharA., ReichensteinM., CohenD., FaermanA., CopelandN.G., GilbertD.J., JenkinsN.A. & ShaniM. (2001). A novel transgenic marker for migrating limb muscle precursors and for vascular smooth muscle cells. Developmental Dynamics220, 60–73.
12.
PfisterF., FengY., vom HagenF., HoffmannS., MolemaG., HillebrandsJ.L., ShaniM., DeutschU. & HammesH.P. (2008). Pericyte migration: A novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes57, 2495–2502.
13.
RiveraL.B. & BrekkenR.A. (2011). SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-beta1 activity. Journal of Cell Biology193, 1305–1319.
14.
Hall-GlennF., De YoungR.A., HuangB.L., van HandelB., HofmannJ.J., ChenT.T., ChoiA., OngJ.R., BenyaP.D., MikkolaH., Iruela-ArispeM.L. & LyonsK.M. (2012). CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One7, e30562.
15.
StatonC.A., ReedM.W. & BrownN.J. (2009). A critical analysis of current in vitro and in vivo angiogenesis assays. International Journal of Experimental Patholology90, 195–221.
16.
BersiniS. & MorettiM. (2015). 3D functional and perfusable microvascular networks for organotypic microfluidic models. Journal of Materials Science. Materials in Medicine26, 5520.
17.
SongJ.W. & MunnL.L. (2011). Fluid forces control endothelial sprouting. Proceedings of the National Academy of Sciences of the USA108, 15,342-15,347.
JeonJ.S., ZervantonakisI.K., ChungS., KammR.D. & CharestJ.L. (2013). In vitro model of tumor cell extravasation. PLoS One8, e56910.
22.
ZervantonakisI.K., Hughes-AlfordS.K., CharestJ.L., CondeelisJ.S., GertlerF.B. & KammR.D. (2012). Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proceedings of the National Academy of Sciences of the USA109, 13,515-13,520.
23.
ChenM.B., SrigunapalanS., WheelerA.R. & SimmonsC.A. (2013). A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactions. Lab on a Chip13, 2591–2598.
24.
ChrobakK.M., PotterD.R. & TienJ. (2006). Formation of perfused, functional microvascular tubes in vitro. Microvascular Research71, 185–196.
25.
PriceG.M., WongK.H., TruslowJ.G., LeungA.D., AcharyaC. & TienJ. (2010). Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels. Biomaterials31, 6182–6189.
26.
van der MeerA.D., OrlovaV.V., ten DijkeP., van den BergA. & MummeryC.L. (2013). Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device. Lab on a Chip13, 3562–3568.
ZhengY., ChenJ., CravenM., ChoiN.W., TotoricaS., Diaz-SantanaA., KermaniP., HempsteadB., Fischbach-TeschlC., LópezJ.A. & StroockA.D. (2012). In vitro microvessels for the study of angiogenesis and thrombosis. Proceedings of the National Academy of Sciences of the USA109, 9342–9347.
29.
BichselC.A., HallS.R., SchmidR.A., GuenatO. & GeiserT. (2015). Primary human lung pericytes support and stabilize in vitro perfusable microvessels. Tissue Engineering. Part A [E-pub ahead of print.]