Abstract
Progress toward implementation of the Three Rs is affected by a complexity of personality and sociological factors, recognised in The Principles in 1959, but no less effective in the 21st century
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References
1.
Russell W.M.S.
&
Burch R.L.
(1959 ). The Principles of Humane Experimental Technique , xiv + 238 pp. London, UK : Methuen .