Special Anniversary Volume — Issue 5: Replacement —Focus on In Silico Methods

Rowan A.N. & Stratman C.J. (1979). The Use of Alternatives in Drug Research, 177 pp. London & Basingstoke, UK: Macmillan.

Hansch C. (1979). Computer-assisted studies in drug design. In The Use of Alternatives in Drug Research (ed. Rowan A.N. & Stratman C.J. ), pp. 1–13. London & Basingstoke, UK: Macmillan.

Cronin M. (2009). In silico toxicology challenges for pharmaceuticals: complacency or controversy? ATLA 37, 453–456.

Boyer S. (2009). The use of computer models in pharmaceutical safety evaluation. ATLA 37, 467–475.

Vedani A. & Smiesko M. (2009). In silico toxicology in drug discovery — concepts based on three-dimensional models. ATLA 37, 477–496.

Cronin M.T.D. , Bajot F. , Enoch S.J. , Madden J.C. , Roberts D.W. & Schwöbel J. (2009). The in chemico–in silico interface: challenges for integrating experimental and computational chemistry to identify toxicity. ATLA 37, 513–521.

Yang C. , Valerio L.G. & Arvidosin K.B. (2009). Computational toxicology approaches at the US Food and Drug Administration. ATLA 37, 523–531.

FDA (2009). US FDA Critical Path Initiative. Available at: http://www.fda.gov/ScienceResearch/SpecialTopics/CriticalPathInitiative/default.htm (Accessed 09.09.09). Washington, DC, USA: US Food and Drug Administration, Department of Health and Human Services.

National Research Council (2007). Toxicity Testing in the 21st Century: A Vision and a Strategy, 216 pp. Washington, DC, USA: The National Academies Press.

Thomas S.D. (2009). Physiologically-based simulation modelling for the reduction of animal use in the discovery of novel pharmaceuticals. ATLA 37, 497–511.

Ellison C.M. , Enoch S.J. , Cronin M.T.D. , Madden J.C. & Judson P. (2009). Definition of the applicability domains of knowledge-based predictive toxicology expert systems by using a structural fragment-based approach. ATLA 37, 533–545.

Vonk J.A. , Benigni R. , Hewitt M. , Nendza M. , Segner H. , van de Meent D. & Cronin M.T.D. (2009). The use of mechanisms and modes of toxic action in integrated testing strategies: The report and recommendations of a workshop held as part of the European Union OSIRIS Integrated Project. ATLA 37, 557–571.

Paget G.E. (1979). Concluding remarks. In The Use of Alternatives in Drug Research (ed. Rowan A.N. & Stratman C.J. ), pp. 175–177. London & Basingstoke, UK: Macmillan.