Refinement : A Sense of Progress

Russell W.M.S. & Burch R.L. (1959). The Principles of Humane Experimental Technique, 238 pp. London, UK: Methuen.

Smaje L.H. , Smith J.A. , Combes R.D. , Ewbank R. , Gregory J.A. , Jennings M. , Moore G.J. & Morton D.B. (1998). Advancing refinement of laboratory animal use. Laboratory Animals 32, 137–142.

Lord Smith of Clifton (Chairman) (2002). House of Lords Select Committee on Animals in Scientific Procedures Report. Volume 1: Report, 82 pp. London, UK: The Stationery Office.

Nuffield Council on Bioethics (2005). The Ethics of Research Involving Animals, 335 pp. London, UK: Nuffield Council on Bioethics.

NC3Rs (2009). Views on the 3Rs. In Annual Report 2008: Realising the Potential, pp. 26–27. London, UK: National Centre for the Replacement, Refinement and Reduction of Animals in Research. Available at: www.nc3rs.org.uk/page.asp?id=201 (Accessed 02.04.09).

Home Office (2005). Animals (Scientific Procedures) Act 1986: Application for a Project Licence. Available at: http://scienceandresearch.homeoffice.gov.uk/animal-research/publications-and-reference/publications/licences/project-licences/ (Accessed 02.04.09).

Anon. (1986). Council Directive of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes (86/609/EEC). Official Journal of the European Union L358, 18.12.1986, 1–28. Available at: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31986L0609:en:HTML (Accessed 02.04.09).

OECD (2000). OECD Environmental Health and Safety Publications: Series on Testing and Assessment No. 19. Guidance Document on the Recognition, Assessment, and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation. ENV/JM/MONO(2000)7, 39 pp. Paris, France: Organisation for Economic Cooperation and Development.

Castle P. (1999). The European Pharmacopoeia and humane endpoints. In Humane Endpoints in Animal Experiments for Biomedical Research (ed. Hendriksen C.F.M. & Morton D.B. ), pp.15–19. London, UK: Royal Society of Medicine Press.

Castle P. (2007). Replacement, reduction, refinement. In Animal Welfare Progress — the 3Rs. Pharmeuropa 19.3, 430–441.

NC3Rs (2008). NC3Rs Guidelines: Primate Accomodation, Care and Use, 24 pp. London, UK: National Centre for the Replacement, Refinement and Reduction of Animals in Research. Available at: www.nc3rs.org.uk/primatesguidelines (Accessed 03.04.09).

BBSRC (2006). UK invests to strengthen best practice in animal research. Available at: http://www.bbsrc.ac.uk/media/releases/2006/060613_capacity.html (Accessed 03.04.09).

APC (2006). Animal Procedures Committee Education and Training Sub-Committee: Review of Modular Training, 31 pp. London, UK: Animal Procedures Committee. Available at: http://www.apc.gov.uk/reference/apc-education-modular-training.pdf (Accessed 03.04.09).

Lloyd M. (2009). Advancing refinement through training: Is there a role for reflective practice? ATLA 37, 167–171.

Smith J.A. , Birke L. & Sadler D. (1997). Reporting animal use in scientific papers. Laboratory Animals 31, 312–317.

Alfaro V. (2005). Specification of laboratory animal use in scientific articles: Current low detail in the journals’ Instructions for Authors and some proposals. Methods & Findings in Experimental & Clinical Pharmacology 27, 495–502.

Osborne N.J. , Payne D. & Newman M.L. (2009). Journal editorial policies, animal welfare and the 3Rs. American Journal of Bioethics (in press).

Jennings M. (1994). Ethics Committees for Laboratory Animals: A Basis for Their Composition and Function, 12 pp. Horsham, UK: RSPCA.

Home Office (1998). The Ethical Review Process: Statement, 3 pp. London, UK: Home Office. Available at: http://www.scienceandresearch.homeoffice.gov.uk/animal-research/publications-and-reference/publications/guidance/ethical-review-process/ (Accessed 03.04.09).

Home Office (2000). Appendix J: The Ethical Review Process. In Guidance on the Operation of the Animals (Scientific Procedures) Act 1986. HC321. London, UK: The Stationery Office. Available at: http://www.archive.official-documents.co.uk/document/hoc/321/321-xj.htm (Accessed 03.04.09).

LASA (2004). Laboratory Animal Science Association: Guidance Notes on Retrospective Review. A Discussion Document Prepared by the LASA Ethics and Training Group. (ed. Jennings M. & Howard B. ), 10 pp. Tamworth, UK: Laboratory Animal Science Association. Available at: www.lasa.co.uk/Guidance%20notes%20RR%20(2004).pdf (Accessed 03.04.09).

Smith J.A. & Jennings M. (2009). A Resource Book for Lay Members of Ethical Review Processes. 2nd edition. (in press). Horsham, UK: RSPCA.

Smith J.A. & Jennings M. (2003). A Resource Book for Lay Members of Ethical Review Processes, 58 pp. Horsham, UK: RSPCA.