Fifty Years after Russell and Burch,Toxicologists Continue to Ignore Genetic Variation in Their Test Animals

Russell W.M.S. & Burch R.L. (1959). The Principles of Humane Experimental Technique. Special Edition, 238 pp. London, UK: Methuen.

Committee on Toxicity Testing and Assessment of Environmental Agents (2007). Toxicity Testing in the 21st. Century a Vision and a Strategy, v-196, 216 pp. Washington, DC, USA: The National Academies Press.

FDA (2004). Challenge and Opportunity on the Critical Path to New Medical Products. Rockville, MD, USA: US Food and Drug Administration. Available at: http://www.fda.gov/oc/initiatives/criticalpath/whitepaper.html (Accessed 14.01.09).

FDA (undated). FDA's Critical Path Initiative. Rockville, MD, USA: US Food and Drug Administration. Available at: http://www.fda.gov/oc/initiatives/criticalpath/ (Accessed 14.01.09).

IMI (2008). The Innovative Medicines Initiative (IMI) Research Agenda. Available at: http://imi.europa.eu/docs/imi-gb-006v2-15022008-research-agenda_en.pdf (Accessed 14.01.09).

Fisher R.A. (1942). The Design of Experiments, 248 pp. Edinburgh, UK: Oliver & Boyd.

Committee on Toxicity (2007). Variability and Uncertainty in Toxicology of Chemicals in Food, Consumer Products and the Environment, 194 pp. London, UK: Food Standards Agency.

Smits B.M. , Van Zutphen B.F. , Plasterk R.H. & Cuppen E. (2004). Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Research 14, 1285–1290.

Petkov P.M. , Ding Y. , Cassell M.A. , Zhang W. , Wagner G. , Sargent E.E. , Asquith S. , Crew V , Johnson K.A. , Robinson P. , Scott V.E. & Wiles M.V. (2004). An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Research 14, 1806–1811.

Festing M.F.W. , Diamanti P. & Turton J.A. (2001). Strain differences in haematological response to chloramphenicol succinate in mice: implications for toxicological research. Food & Chemical Toxicology 39, 375–383.

Kimber I. , Dearman R.J. , Basketter D.A. , Ryan C.A. & Gerberick G.F. (2002). The local lymph node assay: past, present and future. Contact Dermatitis 47, 315–328.

Altman D.G. (1991). Practical Statistics for Medical Research, 624 pp. London, UK: Chapman & Hall.

Shirley E. (1996). A literature review of statistical methods for the analysis of general toxicological data. In Statistics in Toxicology (ed. Morgan B.J.T. ), pp. 20–32. Oxford, UK: Clarendon Press.

Ho G. , Zhang C. & Zhuo L. (2007). Non-invasive fluorescent imaging of gliosis in transgenic mice for profiling developmental neurotoxicity. Toxicology & Applied Pharmacology 221, 76–85.

Kimber I. , Dearman R.J. , Betts C.J. , Gerberick G.F. , Ryan C.A. , Kern P.S. , Patlewicz G.Y. & Basketter D.A. (2006). The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements? Contact Dermatitis54, 181–185.

Festing M.F.W. (1986). The case for isogenic strains in toxicological screening. Archives of Toxicology 9, Suppl., 127–137.

Festing M.F.W. (1987). Genetic factors in toxicology: implications for toxicological screening. CRC Critical Reviews in Toxicology 18, 1–26.

Festing M.F.W. (1995). Use of a multi-strain assay could improve the NTP carcinogenesis bioassay program. Environmental Health Perspectives 103, 44–52.

Festing M.F.W. (1995). Genetic variation in human and laboratory animal populations and its implications for toxicological research and human risk assessment. In Molecular and Cellular Mechanisms in Toxicology (ed. De Matteis F. ), pp. 165–184. Boca Raton, FL, USA: CRC Press, Inc.

Festing M.F.W. (1997). Fat rats and carcinogen screening. Nature, London 388, 321–322.

Chia R. , Achilli F. , Festing M.F. & Fisher E.M. (2005). The origins and uses of mouse out-bred stocks. Nature Genetics 37, 1181–1186.