BernsteinI.L., Chan-YeungM., MaloJ-L., & BernsteinD.I. (2006). Asthma in the Workplace. 3rd edn, 621 pp. New York, NY, USA: Taylor & Francis.
2.
KimberI., & DearmanR.J. (1997). Toxicology of Chemical Respiratory Hypersensitivity, 302 pp. London, UK: Taylor & Francis.
3.
CannonJ., CullinanP., & NewmanT.A. (1995). Consequences of occupational asthma. British Medical Journal311, 602–603.
4.
LissG.M., TarloS.M., MacfarlaneY., & YeungK.S. (2000). Hospitalization among workers compensated for occupational asthma. American Journal of Respiratory and Critical Care Medicine162, 112–118.
5.
RachiotisG., SavaniR., BrantA., MacNeillS., Newman TaylorA.J., & CullinanP. (2006). The outcome of occupational asthma after cessation of exposure: a systematic review. Thorax62, 147–152.
6.
Health and Safety Executive (2006). The True Cost of Occupational Asthma in Great Britain. Research Report 474, 122 pp. London, UK: Health and Safety Executive. Website http://www.hse.gov.uk/RESEARCH/rrpdf/rr474.pdf
7.
SastreJ., & QuirceS. (2003). Sensitizing Agents Inducers of Occupational Asthma and Hypersensitivity Pneumonitis.Madrid, Spain: Quirce Fundación Jiménez Diaz, Servicio de Alergia, Universidad Autonoma de Madrid. Website http://www.eaaci.net/site/content.php?artid=792 (Accessed 22.03.07).
8.
ManninoD.M. (2000). How much asthma is occupationally related?Occupational Medicine15, 359–368.
9.
MeredithS., & NordmanH. (1996). Occupational asthma: measures of frequency from four countries. Thorax51, 435–440.
10.
BalmesJ., BecklakeM., BlancP., HennebergerP., KreissK., MappC., MiltonD., SchwartzD., TorenK., & ViegiG. (2003). American Thoracic Society Statement: Occupational contribution to the burden of airway disease. American Journal of Respiratory and Critical Care Medicine167, 787–797.
11.
BlancP.D., & TorenK. (1999). How much adult asthma can be attributed to occupational factors?American Journal of Medicine107, 580–587.
12.
SiracusaA., DesrosiersM., & MarabiniA. (2000). Epidemiology of occupational rhinitis: prevalence, aetiology and determinants. Clinical and Experimental Allergy30, 1519–1534.
13.
MappC.E., BoschettoP., MaestrelliP., & FabbriL.M. (2005). Occupational asthma. American Journal of Respiratory and Critical Care Medicine172, 280–305.
14.
NielsenJ., WelinderH., BensrydI., RylanderL., & SkerfvingS. (2006). Ocular and airway symptoms related to organic acid anhydride exposure — a prospective study. Allergy61, 743–749.
MaestrelliP., FabbriL.M., & MappC.E. (2006). Pathophysiology. In Asthma in the Workplace, 3rd edn (ed. BernsteinI.L., Chan-YeungM., MaloJ-L., & BarnsteinD.), pp. 109–140. New York, NY, USA: Taylor & Francis.
17.
JonesM.G., FloydA., Nouri-AriaK.T., JacobsonM.R., DurhamS.R., Newman TaylorA.J., & CullinanP. (2006). Is occupational asthma to diisocyanates a non-IgE-mediated disease?Journal of Allergy and Clinical Immunology117, 663–669.
18.
BernsteinD.I., CartierA., CoteJ., MaloJ-L., BouletL.P., WannerM., MilotJ., L'ArchevequeJ., TrudeauC., & LummusZ. (2002). Diisocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficiency than specific antibodies for identification of isocyanate asthma. American Journal of Respiratory and Critical Care Medicine166, 436–437.
19.
MaloJ.L., & Chan-YeungM. (2001). Occupational asthma. Journal of Allergy and Clinical Immunology108, 317–328.
20.
LiuQ., & WisnewskiA.V. (2003). Recent developments in diisocyanate asthma. Annals of Allergy, Asthma and Immunology90, 35–41.
21.
SastreJ., VandenplasO., & ParkH-S. (2003). Pathogenesis of occupational asthma. European Respiratory Journal22, 364–373.
22.
HendrickD.J. (2001). The world wide problem of occupational asthma. Clinical and Experimental Allergy31, 1–4.
23.
TarloS.M., & MaloJ-L. (2006). An ATS/ERS report: 100 questions and needs in occupational asthma. European Respiratory Journal27, 607–614.
24.
CullinanP. (1998). Occupational asthma, IgE and IgG. Clinical and Experimental Allergy28, 668–670.
25.
KimberI., WarbrickE.V., & DearmanR.J. (1998). Chemical respiratory allergy, IgE and the relevance of predictive test methods: a commentary. Human and Experimental Toxicology17, 537–540.
26.
CartierA., GrammerL.C., MaloJ-L., LagierF., ChezzoH., HarrisK., & PattersonR. (1989). Specific serum antibodies against isocyanates. Association with occupational asthma. Journal of Allergy and Clinical Immunology84, 507–514.
27.
VandenplasO., CartierA., LesageJ., CloutierY., PerreaultG., GrammerL.C., ShaughnessyM.A., & MaloJ-L. (1993). Prepolymers of hexamethylene diisocyanate as a cause of occupational asthma. Journal of Allergy and Clinical Immunology91, 850–861.
28.
TeeR.D., CullinanP., WelchJ., BurgeP.S., & Newman TaylorA.J. (1998). Specific IgE to isocyanate: a useful diagnostic role in occupational asthma. Journal of Allergy and Clinical Immunology101, 709–715.
29.
TarloS.M. (1999). Diisocyanate sensitization and antibody production. Journal of Allergy and Clinical Immunology103, 739–741.
30.
ParkH-S., LeeS-K., KimH-Y., NahmD-H., & KimS-S. (2002). Specific immunoglobulin E and immunoglobulin G antibodies to toluene diisocyanate–human serum albumin conjugate: useful markers for predicting long-term prognosis in toluene diisocyanate-induced asthma. Clinical and Experimental Allergy32, 551–555.
31.
KimberI., & DearmanR.J. (2002). Chemical respiratory allergy: role of IgE antibody and relevance of route of exposure. Toxicology181-182, 311–315.
WassU., & BelinL. (1989). Immunologic specificity of isocyanate-induced IgE antibodies in serum from 10 sensitized workers. Journal of Allergy and Clinical Immunology83, 126–135.
34.
SonM., LeeM., KimY.T., YounJ.K., & ParkH. (1998). Heterogeneity of IgE response to TDI–HSA conjugates by ELISA in toluene diisocyanate (TDI)-induced occupational asthma (OA) patients. Journal of Korean Medical Science13, 147–152.
35.
AulD.J., BhaumikA., KennedyA.L., BrownW.E., LesageJ., & MaloJ-L. (1999). Specific IgG response to monomeric and polymeric MDI conjugates in subjects with respiratory reactions to isocyanates. Journal of Allergy and Clinical Immunology103, 749–755.
36.
ParkH.S., LeeS.K., LeeY.M., KimS.S., & NahmD.H. (2002). Longitudinal study of specific antibodies to toluene diisocyanate (TDI)–human serum albumin (HSA) conjugate in patients with TDI-induced asthma. Korean Journal of Internal Medicine17, 249–251.
37.
BentleyA.M., MaestrelliP., SaettaM., FabbriL.M., RobinsonD.S., BradleyB.L., JeffreyP.K., DurhamS.R., & KayA.B. (1992). Activated T lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma. Journal of Allergy and Clinical Immunology89, 821–829.
38.
MaestrelliP., OccariP., TuratoG., PapirisS.A., Di StefanoA., MappC.E., MilaniG.F., FabbriL.M., & SaettaM. (1997). Expression of interleukin (IL)-4 and IL-5 proteins in asthma induced by toluene diisocyanate (TDI). Clinical and Experimental Allergy27, 1292–1298.
39.
DearmanR.J., & KimberI. (1991). Differential stimulation of immune function by contact and respiratory chemical allergens. Immunology72, 563–570.
40.
KimberI., & DearmanR.J. (1997). Cell and molecular biology of chemical allergy. Clinical Reviews of Allergy and Immunology15, 145–168.
41.
DearmanR.J., WarbrickE.V., HumphreysI.R., & KimberI. (2000). Characterisation in mice of the immunological properties of five allergenic acid anhydrides. Journal of Applied Toxicology20, 221–230.
42.
HerrickC.A., DasJ., WisnewskiA.V., RedlichC., & BottomlyK. (2003). Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: genetic control of Th2-induced lung inflammation. Journal of Allergy and Clinical Immunology111, 1087–1094.
43.
FarrajA.K., HarkemaJ.R., & KaminskiN.E. (2004). Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicological Sciences79, 315–325.
44.
WisnewskiA.V., HerrickC.A., LiuQ., ChenL., BottomlyK., & RedlichC.A. (2003). Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate. Journal of Allergy and Clinical Immunology112, 538–546.
45.
MaestrelliP., Del PreteG.F., De CarliM., D'EliosM.M., SaettaM., Di StefanoA., MappC.E., RomagnaniS., & FabbriL.M. (1994). CD8 T cell clones producing interleukin-5 and interferongamma in bronchial mucosa of patients with asthma induced by toluene diisocyanate. Scandinavian Journal of Work and Environmental Health20, 376–381.
46.
AkdisM., VerhagenJ., TaylorA., KaramlooF., KaragiannidisC., CrameriR., ThunbergS., DenizG., ValentaR., FiebigH., KegelC., DischR., Schmidt-WeberC.B., BlaserK., & AkdisC.A. (2004). Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. Journal of Experimental Medicine199, 1567–1575.
47.
DearmanR.J., BettsC.J., HumphreysN., FlanaganB.F., GilmourN.J., BasketterD.A., & KimberI. (2003). Characterization of chemical allergens as a function of cytokine profiles. Toxicological Sciences71, 137–145.
48.
KimberI., & DearmanR.J. (2005). What makes a chemical a respiratory sensitizer?Current Opinion in Allergy and Clinical Immunology5, 119–124.
49.
HopkinsJ.E., NaisbittD.J., KitteringhamN.R., DearmanR.J., KimberI., & ParkB.K. (2005). Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine production. Chemical Research in Toxicology18, 375–381.
50.
CumberbatchM., ClellandK., DearmanR.J., & KimberI. (2005). Impact of cutaneous IL-10 on resident epidermal Langerhans cells and the development of polarized immune responses. Journal of Immunology175, 43–50.
51.
KimberI., BernsteinI.L., KarolM.H., RobinsonM.K., SarloK., & SelgradeM.K. (1996). Identification of respiratory allergens. Fundamental and Applied Toxicology33, 1–10.
52.
HolsappleM.P., JonesD., KawabataT.T., KimberI., SarloK., SelgradeM.K., ShahJ., & WoolhiserM.R. (2006). Assessing the potential to induce respiratory hypersensitivity. Toxicological Sciences91, 4–13.
53.
BothamP.A., HextP.M., RattrayN.J., WalshS.T., & WoodcockD.R. (1988). Sensitisation of guinea pigs by inhalation exposure to low molecular weight chemicals. Toxicology Letters41, 159–173.
54.
BlaikieL., MorrowT., WilsonA.P., HextP., HartopP.J., RattrayN.J., WoodcockD.R., & BothamP.A. (1995). A two-centre study for the evaluation and validation of an animal model for the assessment of the potential of small molecular weight chemicals to cause respiratory allergy. Toxicology96, 37–50.
55.
PauluhnJ., WoolhiserM.R., & BloemenL. (2005). Repeated inhalation challenge with diphenylmethane-4,4’-diisocyanate in Brown Norway rats leads to a time-related increase of neutrophils in bronchoalveolar lavage after topical induction. Inhalation Toxicology17, 67–78.
56.
RattrayN.J., BothamP.A., HextP.M., WoodcockD.R., FieldingI., DearmanR.J., & KimberI. (1994). Induction of respiratory hypersensitivity to diphenylmethane-4,4’-diisocyanate (MDI) in guinea pigs. Influence of route of exposure. Toxicology88, 15–30.
57.
ArtsJ., KuperC.F., SpoorS.M., & BloksmaN. (1998). Airway morphology and function of rats following dermal sensitization and respiratory challenge with low molecular weight chemicals. Toxicology and Applied Pharmacology152, 66–76.
58.
ArtsJ., de KoningM., BloksmaN., & KuperC.F. (2004). Respiratory allergy to trimellitic anhydride in rats: concentration–response relationships during elicitation. Inhalation Toxicology16, 259–269.
59.
PauluhnJ. (2005). Brown Norway rat asthma model of diphenylmethane 4,4’-diisocyanate. Inhalation Toxicology17, 729–739.
60.
ScheerensH., BuckleyT.L., MuisT.L., GarssenJ., DormansJ., NijkampH.P., & Van LoverenH. (1999). Long-term topical exposure to toluene diisocyanate in mice leads to antibody production and in vivo airway hyperresponsiveness three hours after intranasal challenge. American Journal of Respiratory Critical Care Medicine159, 1074–1080.
61.
LiuY., SparerJ., WoskieS.R., CullenM.R., ChungJ.S., HolmC.T., & RedlichC.A. (2000). Qualitative assessment of isocyanate skin exposure in auto body shops: a pilot study. American Journal of Industrial Medicine37, 265–274.
62.
BeckL.A., & LeungD.Y. (2000). Allergen sensitization through the skin induces systemic allergic responses. Journal of Allergy and Clinical Immunology106, S258–S263.
63.
NemeryB., & LenaertsL. (1993). Exposure to methylene diphenyl diisocyanate in coal mines. The Lancet341, 318.
64.
ArtsJ.H.E., & KuperC.F. (2006). Animal models to test respiratory allergy of low molecular weight chemicals: a guidance. Methods41, 61–71.
65.
KarolM.H. (1983). Concentration-dependent immunologic response to toluene diisocyanate (TDI) following inhalation exposure. Toxicology and Applied Pharmacology68, 229–224.
66.
PauluhnJ. (1997). Assessment of respiratory hypersensitivity in guinea pigs sensitized to toluene diisocyanate: improvements on analysis of respiratory response. Fundamental and Applied Toxicology40, 211–219.
67.
PauluhnJ., ThielA., EmuraM., & MohrU. (2000). Respiratory sensitization to diphenylmethane 4,4’-diisocyanate in guinea pigs: impact of particle size on induction and elicitation of response. Toxicological Sciences56, 105–113.
68.
PauluhnJ., EidmannP., MohrU. (2002). Respiratory hypersensitivity in guinea pigs sensitized to 1,6 hexamethylene diisocyanate (HDI): comparison of results obtained with the monomer and homopolymers of HDI. Toxicology171, 147–160.
69.
KarolM.H., DixonC., BradyM., & AlarieY. (1980). Immunologic sensitization and pulmonary hypersensitivity by repeated inhalation of aromatic isocyanates. Toxicology and Applied Pharmacology53, 260–270.
70.
PauluhnJ., EidmannP., FreybergerA., Wasinska-KempkaG., & VohrH.W. (2002). Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: a comparison of endpoints. Journal of Applied Toxicology22, 89–97.
71.
BothamP.A., RattrayN.J., WoodcockD.R., WalshS.T., & HextP.M. (1989). The induction of respiratory allergy in guinea pigs following intradermal injection of trimellitic anhydride: a comparison with the response to 2,4-dinitrochlorobenzene. Toxicology Letters47, 25–39.
72.
PauluhnJ., & MohrU. (1994). Assessment of respiratory hypersensitivity in guinea pigs sensitized to diphenylmethane-4,4’-diisocyanate (MDI) and challenged with MDI, acetylcholine or MDI–albumin conjugate. Toxicology92, 53–74.
73.
PauluhnJ., DearmanR., DoeJ., HextP., & LandryT.D. (1999). Respiratory hypersensitivity to diphenylmethane 4,4’-diisocyanate in guinea pigs: comparison with trimellitic anhydride. Inhalation Toxicology11, 187–214.
74.
ArtsJ.H.E., BloksmaN., Leusink-MuisA., & KuperC.F. (2003). Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats. Toxicology and Applied Pharmacology187, 38–49.
75.
PauluhnJ. (2003). Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: analysis of dose–response following topical induction and time course following repeated inhalation challenge. Toxicology194, 1–17.
76.
ZhangX.D., FedanJ.S., LewisD.M., & SiegelP.D. (2004). Asthma-like biphasic airway responses in Brown Norway rats sensitized by dermal exposure to dry trimellitic anhydride. Allergy and Clinical Immunology113, 320–326.
77.
GarssenJ., NijkampF.P., WagenaarS.S., ZwartA., AskenaseP.W., & Van LoverenH. (1989). Regulation of delayed-type hypersensitivity-like responses in the mouse lung, determined with histological procedures: serotonin, T-cell suppressor-induced factor and high antigen dose tolerance regulate the magnitude of T-cell dependent inflammatory reactions. Immunology68, 51–58.
78.
SatohT., KramarikJ.A., TollerudD.J., & KarolM.H. (1995). A murine model for assessing the respiratory hypersensitivity potential of chemical allergens. Toxicology Letters78, 57–66.
79.
Van HouwelingenA.H., De JagerS.C., KoolM., Van Heuven-NolsenD., KraneveldA.D., & NijkampF.P. (2002). Hypersensitivity reactions in mouse airways after a single and a repeated hapten challenge. Inflammation Research51, 63–68.
80.
VanoirbeekJ.A.J., TarkowskiM., CeuppensJ.L., VerbekenE.K., NemeryB., & HoetP.M. (2004). Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice. Toxicologic Sciences80, 310–321.
81.
ZwartA., ArtsJ.H.E., & KuperC.F. (1994). Wave propagation: a new parameter in the description of mechanical airway impedance. European Respiratory Reviews4, 203–209.
82.
ArakawaH., LötvallJ., KawikovaI., TeeR., HayesJ., LöfdahlC.G., TaylorA.J., & SkooghB.E. (1993). Airway allergy to trimellitic anhydride in guinea pigs: different time courses of IgG1 titer and airway responses to allergen challenge. Journal of Allergy and Clinical Immunology92, 425–434.
83.
ArakawaH., LötvallJ., KawikovaI., MorikawaA., LöfdahlC.G., & SkooghB.E. (1995). Airway responses following intradermal sensitization to different types of allergens: ovalbumin, trimellitic anhydride and Dermatophagoides farinae.International Archives of Allergy and Immunology108, 274–280.
84.
NabeT., YamauchiK., ShinjoY., NiwaT., ImotoK., KodaA., & KohnoS. (2005). Delayed type asthmatic response induced by repeated intratracheal exposure to toluene-2,4-diisocynate in guinea pigs. International Archives of Allergy and Immunology137, 115–124.
85.
ZhangX.D., LötvallJ., ArakawaH., WelinderH., & SkerfvingS. (1998). Relationship between IgG1 levels and airway responses in guinea pigs actively and passively sensitized to hexahydrophthalic anhydride. Allergy53, 20–27.
86.
RegalJ.F., MohrmannM.E., & SailstadD.M. (2001). Trimellitic anhydride-induced eosinophilia in a mouse model of occupational asthma. Toxicology and Applied Pharmacology175, 234–242.
87.
KlinkB., & MeadeJ. (2003). Dermal exposure to 3-amino-5-mercapto-1,2,4-triazole (AMT) induces sensitization and airway hyperreactivity in BALB/c mice. Toxicological Sciences75, 89–98.
88.
DearmanR.J., MitchellJ.A., BasketterD.A., & KimberI. (1992). Differential ability of occupational chemical contact and respiratory allergens to cause immediate and delayed dermal hypersensitivity reactions in mice. International Archives of Allergy and Immunology97, 315–321.
89.
EbinoK., LemusR., & KarolM.H. (1999). The importance of the diluent for airway transport of toluene diisocyanate following intranasal dosing of mice. Inhalation Toxicology11, 171–185.
90.
GermannP.G., HaefnerD., HanauerG., & DrommerW. (1998). Incidence and severity of granulomatous pneumonia in Brown Norway (BN) rats: Breeder related variations. Journal of Experimental Animal Science39, 22–33.
91.
PauluhnJ., & MohrU. (2005). Experimental approaches to evaluate respiratory allergy in animal models. Experimental and Toxicologic Pathology56, 203–234.
92.
ArtsJ.H.E., de KoningM.W., BloksmaN., & KuperC.F. (2001). Respiratory irritation by trimellitic anhydride in Brown Norway and Wistar rats. Inhalation Toxicology13, 719–728.
93.
BatesJ., IrvinC., BrusascoV., DrzaenJ., FredbergJ., LoringS., EidelmanD., LudwigM., MacklemP., MartinJ., Milic-EmiliJ., HantosZ., HyattR., Lai-FookS., LeffA., SolwayJ., LutchenK., SukiB., MitznerW., PareP., PrideN., & SlyP. (2004). The use and misuse of Penh in animal models of lung disease. American Journal of Respiratory Cellular Molecular Biology31, 373–374.
94.
HamelmannE., TakedaK., OshibaA., & GelfandE.W. (1999). Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness — a murine model. Allergy54, 297–305.
95.
BoerJ., DuyvendakM., SchuurmanF.E., PouwF.M., ZaagsmaJ., & MeursH. (1999). Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea pigs. British Journal of Pharmacology128, 1114–1120.
96.
ZeissC.R., & PattersonR. (1993). Acid anhydrides. In Asthma in the workplace, 1st edn (ed. BernsteinI.L., Chan-YeungM., MaloJ.L., & BernsteinD.I.), pp. 439–457. New York, NY, USA: Marcel Dekker.
97.
BernsteinJ.A., BernsteinD.I., & BernsteinI.L. (1997). Occupational respiratory allergy. In Toxicology of Chemical Respiratory Hypersensitivity (ed. KimberI., & DearmanR.J.), pp. 29–59. London, UK: Taylor & Francis.
98.
SandlerH.M. (2000). Regulating allergies at the workplace. Occupational Hazards62, 149–151.
99.
TaoY., SugiuraT., NakamuraH., KidoM., TanakaI., & KuroiwaA. (1991). Experimental lung injury induced by trimellitic anhydride inhalation on guinea pigs. International Archives of Allergy and Applied Immunology96, 119–127.
100.
ObataH., TaoY., KidoM., NagataN., TanakaI., & KuroiwaA. (1992). Guinea pig model of immunologic asthma induced by inhalation of trimellitic anhydride. American Review of Respiratory Diseases146, 1553–1558.
101.
O'HollarenM.T. (1995). Dyspnea and the larynx. Annual Allergy and Asthma Immunology75, 1–4.
102.
SalaE., HytonenM., TupaselaO., & EstlanderT. (1996). Occupational laryngitis with immediate allergic or immediate type specific chemical hypersensitivity. Clinical Otolaryngology Allied Sciences21, 42–48.
103.
BaurX. (1995). Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. Journal of Allergy and Clinical Immunology95, 1004–1010.
104.
EpsteinM.M. (2004). Do mouse models of allergic asthma mimic clinical disease?International Archives of Allergy and Immunology133, 84–100.
105.
ArellanoP.J.L., GonzalesB.N.M., DominguezM.T., De SotoS.B.M.L., & LopezJ.A. (1992). Experimental models of hypersensitivity pneumonitis. Journal of Investigative Allergology and Clinical Immunology2, 219–228.
106.
DearmanR.J., BasketterD.A., & KimberI. (1992). Variable effects of chemical allergens on serum IgE concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers. Journal of Applied Toxicology12, 317–323.
107.
HiltonJ., DearmanR.J., BasketterD.A., & KimberI. (1995). Identification of chemical respiratory allergens: dose response relationships in the mouse IgE test. Toxicology Methods5, 51–60.
108.
PotterD.W., & WederbrandK.S. (1995). Total IgE antibody in BALB/c strain mice after dermal exposure to chemicals. Fundamental and Applied Toxicology26, 127–135.
109.
DearmanR.J., BasketterD.A., BlaikieL., ClarkE.D., HiltonJ., HouseR.V., LadicsG.S., LovelessS.E., MattisC., SailstadD.M., SarloK., SelgradeM.K., & KimberI. (1998). The mouse IgE test: interlaboratory evaluation and comparison of BALB/c and C57BL/6 strain mice. Toxicology Methods8, 69–85.
110.
ArtsJ.H.E., DrogeS.C.M., SpanhaakS., BloksmaN., PennincksA.H., & KuperC.F. (1997). Local lymph node activation and IgE responses in Brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals. Toxicology117, 229–237.
111.
WarbrickE.V., DearmanR.J., & KimberI. (2002). Induced changes in the total serum IgE concentration in the Brown Norway rat: potential for identification of chemical respiratory allergens. Journal of Applied Toxicology22, 1–11.
112.
ZhangX.D., MurrayD.K., LewisD.M., & SeigelP.D. (2002). Dose–response and time course of specific IgE and IgG after single and repeated topical skin exposure to dry trimellitic anhydride powder in a Brown Norway rat model. Allergy57, 620–626.
113.
DearmanR.J., SkinnerR.A., HumphreysN.J., & KimberI. (2003). Methods for the identification of chemical respiratory allergens in rodents: comparisons of cytokine profiling with induced changes in serum IgE. Journal of Applied Toxicology23, 199–207.
114.
DearmanR.J., SmithS., BasketterD.A., & KimberI. (1997). Classification of chemical allergens according to cytokine secretion profiles of murine lymph node cells. Journal of Applied Toxicology17, 53–62.
115.
DearmanR.J., WarbrickE.V., SkinnerR., & KimberI. (2002). Cytokine fingerprinting of chemical allergens: species comparisons and statistical analyses. Food and Chemical Toxicology40, 107–118.
116.
HayashiM., HigashiK., KatoH., & KanekoH. (2001). Assessment of preferential Th1 or Th2 induction by low-molecular-weight compounds using a reverse transcription-polymerase chain reaction method: comparison of two mouse strains, C57BL/6 and BALB/c. Toxicology and Applied Pharmacology177, 38–45.
117.
DearmanR.J., & KimberI. (2001). Cytokine fingerprinting and hazard assessment of chemical respiratory allergy. Journal of Applied Toxicology21, 153–163.
118.
VandebrielR.J., De JongW.H., SpiekstraS.W., Van DjikM., FluitmanA., GarssenJ., & Van LoverenH. (2000). Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-γ and interleukin-4. Toxicology and Applied Pharmacology162, 77–85.
119.
ManetzT.C., PettitD.A., & MeadeB.J. (2001). The determination of draining lymph node cell cytokine mRNA levels in BALB/c mice following dermal sodium lauryl sulfate, dinitrofluorobenzene, and toluene diisocyanate exposure. Toxicology and Applied Pharmacology171, 174–183.
120.
Van OchF.M.M., van LoverenH., de JongW.H., & VandebrielR. (2002). Cytokine production induced by low molecular weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers. Toxicology and Applied Pharmacology184, 46–56.
121.
UlrichP., GrenetO., BluemelJ., VohrH.W., WiemannC., GrundlerO., & SuterW. (2001). Cytokine expression profiles during murine contact allergy: T helper 2 cytokines are expressed irrespective of the type of contact allergen. Archives of Toxicology75, 470–479.
122.
SelgradeM., BoykinE.H., Haykal-CoatesN., WoolhiserM.R., WeiscinskiC., AndrewsD.L., FarrajA.J., DoerflerD.L., & GavettS.H. (2006). Inconsistencies between cytokine profiles, antibody responses, and respiratory hyperresponsiveness following dermal exposure to isocyanates. Toxicological Sciences94, 108–117.
123.
MoussaviA., DearmanR.J., KimberI., & KemenyD.M. (1998). Cytokine production by CD4+ and CD8+ T cells in mice following primary exposure to chemical allergens: evidence for functional differentiation of T lymphocytes in vivo.International Archives of Allergy and Immunology116, 116–123.
124.
BettsC.J., DearmanR.J., FlanaganB.F., & KimberI. (2002). Temporal changes in cytokine gene expression profiles induced in mice by trimellitic anhydride. Toxicology Letters136, 121–131.
125.
RyanC.A., DearmanR.J., KimberI., & GerberickG.F. (1998). Inducible interleukin 4 (IL-4) production and mRNA expression following exposure of mice to chemical allergens. Toxicology Letters94, 1–11.
126.
PlitnickL.M., LovelessS.L., LadicsG.S., HolsappleM.P., SelgradeM.J., SailstadD.M., & SmialowiczR.J. (2002). Cytokine profiling for chemical sensitizers: application of the ribonuclease protection assay and effect of dose. Toxicology and Applied Pharmacology179, 145–154.
127.
PlitnickL.M., LovelessS.L., LadicsG.S., HolsappleM.P., SmialowiczR.J., WoolhiserM.R., AndersonP.K., SmithC., & SelgradeM.J. (2005). Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization. Toxicology207, 487–499.
128.
DearmanR.J., RamdinL.S.P., BasketterD.A., & KimberI. (1994). Inducible IL-4-secreting cells provoked in mice during chemical sensitization. Immunology81, 551–557.
129.
DearmanR.J., FilbyA., HumphreysI.R., & KimberI. (2002). Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides. Journal of Applied Toxicology22, 317–325.
130.
AndersenK.E., & MaibachH.I. (1985). Contact Allergy Predictive Tests in Guinea Pigs. Current Problems in Dermatology, Volume 14, 300 pp. Basel, Switzerland: Karger.
131.
BothamP.A., BasketterD.A., MaurerT., MuellerD., PotokarM., & BontinckW.J. (1991). Skin sensitization — a critical review of predictive test methods in animal and man. Food and Chemical Toxicology29, 275–286.
132.
MagnussonB., & KligmanA.M. (1970). Allergic Contact Dermatitis in the Guinea Pig. Identification of Contact Allergens, 141 pp. Springfield, Illinois, USA: Charles C. Thomas.
133.
KimberI., & BasketterD.A. (1992). The murine local lymph node assay; collaborative studies and new directions: A commentary. Food and Chemical Toxicology30, 165–169.
134.
GerberickG.F., RyanC.A., KimberI., DearmanR.J., LeaL.J., & BasketterD.A. (2000). Local lymph node assay validation assessment for regulatory purposes. American Journal of Contact Dermatitis11, 13–18.
HiltonJ., DearmanR.J., HarveyP., EvansP., BasketterD.A., & KimberI. (1998). Estimation of relative skin sensitizing potency using the local lymph node assay: A comparison of formaldehyde and glutaraldehyde. American Journal of Contact Dermatitis9, 29–33.
137.
GerberickG.F., RyanC.A., KernP.S., SchlatterH., DearmanR.J., KimberI., PatlewiczG., & BasketterD.A. (2005). Compilation of historical local lymph node assay data for the evaluation of skin sensitization alternatives. Dermatitis16, 157–202.
138.
KimberI., DearmanR.J., ScholesE.W., & BasketterD.A. (1994). The local lymph node assay: developments and applications. Toxicology93, 13–31.
139.
BarrattM.D., BasketterD.A., & RobertsD.W. (1997). Structure–activity relationships for contact hypersensitivity. In Allergic Contact Dermatitis. The Molecular Basis (ed. LepoittevinJ-P., BasketterD.A., GoossensA., & KarlbergA.T.), pp. 129–154. Heidelberg, Germany: Springer Verlag.
140.
De SilvaO., BasketterD.A., BarrattM.D., CorsiniE., CroninM.T.D., DasP.K., DegwertJ., EnkA., GarrigueJ-L., HauserC., KimberI., LepoittevinJ-P., PeguetJ., & PonecM. (1996). Alternative methods for skin sensitisation testing. The report and recommendations of ECVAM Workshop 19. ATLA24, 683–705.
141.
BarrattM.D., BasketterD.A., ChamberlainM., AdamsG.D., & LangowskiJ.J. (1994). An expert rule base for identifying contact allergens. Toxicology in Vitro8, 1053–1060.
142.
KarolM.H., GrahamC., GealyR.R., MacinaO.T., SussmanN., & RosenkranzH.S. (1996). Structure–activity relationships and computerassisted analysis of respiratory sensitisation potential. Toxicology Letters86, 187–191.
143.
AgiusR.M., NeeJ., McGovernB., & RobertsonA. (1991). Structure activity hypotheses in occupational asthma caused by low molecular weight substances. Annals of Occupational Hygiene35, 129–137.
144.
AgiusR.M., EltonR.A., SawyerL., & TaylorP. (1994). Occupational asthma and the chemical properties of low molecular weight substances. Occupational Medicine44, 34–36.
145.
GrahamC., RosenkranzH.S., & KarolM.H. (1997). Structure–activity model of chemicals that cause human respiratory sensitization. Regulatory Toxicology and Pharmacology26, 296–306.
146.
CunninghamA.R., CunninghamS.L., ConsoerD.M., MossS.T., & KarolM.H. (2005). Development of an information-intensive structure–activity relationship model and its application to human respiratory chemical sensitisers. SAR and QSAR in Environmental Research16, 273–285.
147.
JarvisJ., SeedM.J., EltonR.A., SawyerL., & AgiusR.M. (2005). The relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds. Occupational and Environmental Medicine62, 243–250.
148.
KimberI., CumberbatchM., DearmanR.J., BhushanM., & GriffithsC.E.M. (2000). Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilisation. British Journal of Dermatology142, 401–412.
149.
RoggenE.L., LindstedtM., BorrebaeckC., & VerheyenG.R. (2006). Interactions between dendritic cells and epithelial cells in allergic disease. Toxicology Letters162, 71–82.
150.
Anon. (2003). Technical Guidance Document on Risk Assessment, 2nd edn. Ispra, Italy: European Chemicals Bureau. Website http://ecb.jrc.it/tgd
151.
WhiteA.C., MuellerR.A., GallavanR.H., AaronS., & WilsonA.G. (2003). A multiple in silico program approach for the prediction of mutagenicity from chemical structure. Mutation Research539, 77–89.
152.
BenigniR., & BossaC. (2006). Structure–activity models of chemical carcinogens: state of the art, and new directions. Annuali dell’ Istituto Superiore di Sanitá42, 118–126.
153.
BarrattM.D., & RodfordR.A. (2001). The computational prediction of toxicity. Current Opinion in Chemistry and Biology5, 383–388.
154.
DimitrovS.D., LowL.K., PatlewiczG.Y., KernP.S., DimitrovaG.D., ComberM.H., NiemlaJ., BaileyP.T., & MekenyanO.G. (2005). Skin sensitization: modelling based on skin metabolism simulation and formation of protein conjugates. International Journal of Toxicology24, 189–204.
155.
SerraJ.R., ThompsonE.D., & JursP.C. (2003). Development of binary classification of structural chromosome aberrations for a diverse set of organic compounds from molecular structure. Chemical Research in Toxicology16, 153–163.
156.
AhmedN., DoblerD., DeanM., & ThornalleyP.J. (2005). Peptide mapping identified hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity. Journal of Biological Chemistry208, 5724–5732.
157.
Alvarez-SanchezR., DivkovicM., BasketterD.A., PeaseC., PanicoM., DellA., MorrisH., & LepoittevinJ-P. (2004). Effect of glutathione on the covalent binding of the (13)C-labelled skin sensitiser 5-chloro-2-methylisothiazol-3-one to human serum albumin: Identification of adducts by nuclear magnetic resonance, matrix-assisted laser desorption/ionisation mass spectrometry, and nano-electrospray tandem mass spectrometry. Chemical Research in Toxicology17, 1280–1288.
158.
MeschkatE., BarrattM.D., & LepoittevinJ-P. (2001). Studies of the chemical selectivity of hapten reactivity and skin sensitisation potency. 2. NMR studies of the covalent binding of (13)C-labelled skin sensitisers 2–[13C]- and 3-[13C]hex-1-ene and 3-[13C]hexane-1,3-sultones to human serum albumin. Chemical Research in Toxicology14, 118–126.
159.
MeschkatE., BarrattM.D., & LepoittevinJ-P. (2001). Studies of the chemical selectivity of hapten reactivity and skin sensitisation potency. 1. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labelled skin sensitiser hex-1-ene and hexane-1,3-sultones. Chemical Research in Toxicology14, 110–117.
160.
LepoittevinJ-P. (2005). The chemistry of skin allergy. Proceedings 5th World Congress 200523, 234–238.
161.
RoggenE.L. (2006). Recent developments with B-cell epitope identification for predictive studies. Journal of Immunotoxicology3, 1–13.
162.
MittagD., BatoriV., NeudeckerP., WicheR., FriisE.P., Ballmer-WeberB.K., ViethsS., & RoggenE.L. (2006). A novel approach for investigation of specific and cross-reactive IgE epitopes on Bet v 1 and homologous food allergens in individual patients. Molecular Immunology43, 268–278.
163.
BatoriV., FriisE.P., NielsenH., & RoggenE.L. (2006). An in silico method using an epitope motif database for predicting the location of antigenic determinants on proteins in a structural context. Journal of Molecular Recognition19, 21–29.
164.
ElahiE.N., WrightZ.M., HinselwoodD., SharonA.M., BasketterD.A., & PeaseC.K. (2004). Protein binding and metabolism influence the relative skin sensitisation potential of cinnamic compounds. Chemical Research in Toxicology17, 301–310.
165.
AhlforsS.R., SternerO., & HanssonC. (2003). Reactivity of contact allergenic haptens to amino acid residues in a model carrier peptide, and characterisation of formed peptide–hapten adducts. Skin Pharmacology and Applied Skin Physiology16, 59–68.
166.
SmithC.K., & HotchkissS.A. (2001). Allergic Contact Dermatitis – Chemical and Metabolic Mechanisms, 336 pp. London, UK: Taylor & Francis.
167.
GerberickG.F., VassaloJ.D., BaileyR.E., ChaneyJ.G., MorrallS.W., & LepoittevinJ-P. (2004). Development of a peptide reactivity assay for screening contact allergens. Toxicological Sciences81, 332–343.
168.
CorsiniE., PrimaveraA., MarinovichM., & GalliC.L. (1998). Selective induction of cell-associated interleukin-1alpha in murine keratinocytes by chemical allergens. Toxicology129, 193–200.
169.
CorsiniE., LimiroliE., MarinovichM., CohenC., RoguetR., & GalliC.L. (1999). Selective induction of interleukin-12 by chemical allergens in reconstituted human epidermis. ATLA27, 261–269.
170.
Van OchF.M., Van LoverenH., Van WolfswinkelJ.C., MachielsenA.J., & VandebrielR.J. (2005). Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line. Toxicology210, 95–109.
171.
AibaS., ManomeH., YoshinoY., & TagamiH. (2000). In vitro treatment of human transforming growth factor-beta1-treated monocyte-derived dendritic cells with haptens can induce the phenotypic and functional changes similar to epidermal Langerhans cells in the initiation phase of allergic contact sensitivity reaction. Immunology101, 68–75.
172.
HerouetC., CottinM., LeClaireJ., EnkA., & RoussetF. (2000). Contact sensitizers specifically increase MHC class II expression on murine immature dendritic cells. In Vitro Molecular Toxicology13, 113–123.
173.
AebyP., WyssC., BeckH., GriemP., SchefflerH., & GoebelC. (2004). Characterization of the sensitizing potential of chemicals by in vitro analysis of dendritic cell activation and skin penetration. Journal of Investigative Dermatology122, 1154–1164.
174.
RyanC.A., GildeaL.A., HuletteB.C., DearmanR.J., KimberI., & GerberickG.F. (2004). Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen. Toxicology Letters150, 301–316.
175.
CasatiS., AebyP., BasketterD.A., CavaniA., GennariA., GerberickG.F., GriemP., HartungT., KimberI., LepoittevinJ-P., MeadeB.J., PallardyM., RougierN., RoussetF., RubinstennG., SallustoF., VerheyenG.R., & ZuangV. (2005). Dendritic cells as a tool for the predictive identification of skin sensitisation hazard. The report and recommendations of ECVAM Workshop 51. ATLA33, 47–62.
176.
ToebakM.J., MoedH., von BlombergM.B., BruynzeelD.P., GibbsS., ScheperR.J., & RustemeyerT. (2006). Intrinsic characteristics of contact and respiratory allergens influence production of polarizing cytokines by dendritic cells. Contact Dermatitis55, 238–245.
177.
LebreM.C., AntonsJ.C., KalinskiP., SchuitemakerJ.H., van CapelT.M., KapsenbergM.L., & De JongE.C. (2003). Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a Type-1 polarized phenotype in dendritic cells: role of keratinocyte-derived tumor necrosis factor alpha, type I interferons, and interleukin-18. Journal of Investigative Dermatology120, 990–997.
178.
RyanC.A., GerberickG.F., GildeaL.A., HuletteB.C., BettsC.J., CumberbatchM., DearmanR.J., & KimberI. (2005). Interactions of contact allergens with dendritic cells: opportunities and challenges for the development of novel approaches to hazard assessment. Toxicological Sciences88, 4–11.
179.
AshikagaT., HoyaM., ItagakiH., KatsumuraY., & AibaS. (2002). Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers. Toxicology in Vitro16, 711–716.
180.
AzamP., PeifferJ.L., ChamoussetD., TissierM.H., BonnetP.A., VianL., FabreI., & OurlinJ.C. (2006). The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicology and Applied Pharmacology212, 14–23.
181.
SakaguchiH., AshikagaT., MiyazawaM., YoshidaY., ItoY., YoneyamaK., HirotaM., ItagakiH., ToyodaH., & SuzukiH. (2006). Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT. Toxicology in Vitro20, 774–84.
182.
HuletteB.C., RyanC.A., & GerberickG.F. (2002). Elucidating changes in surface marker expression of dendritic cells following chemical allergen treatment. Toxicology and Applied Pharmacology182, 226–233.
183.
PichowskiJ.S., CumberbatchM., DearmanR.J., BasketterD.A., & KimberI. (2000). Investigation of induced changes in interleukin 1beta mRNA expression by cultured human dendritic cells as an in vitro approach to skin sensitization testing. Toxicology in Vitro14, 351–360.
184.
ToebakM.J., PohlmannP.R., Sampat-Sardjoe-persadS.C., von BlombergB.M., BruynzeelD.P., ScheperR.J., RustemeyerT., & GibbsS. (2006). CXCL8 secretion by dendritic cells predicts contact allergens from irritants. Toxicology in Vitro20, 117–124.
185.
RoggenE., Kristensen SoniN., & VerheyenG.R. (2006). Respiratory immunotoxicology: An in vitro assessment. Toxicology in Vitro20, 1249–1264.
186.
Rothen-RutishauserB.M., KiamaS.G., & GehrP. (2005). A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. American Journal of Respiratory Cell and Molecular Biology32, 281–289.
187.
SheasgreenJ., KlausnerM., KubilisJ., & OgleP. (1999). Reconstructed, differentiated airway epithelial cultures to detect occupational asthma-causing agents. The Toxicologist48, 126.
188.
CustovicA., TaggartS., & FrancisH. (1996). Exposure to house dust mite allergens and the clinical activity of asthma. Journal of Allergy and Clinical Immunology98, 64–72.
189.
BrownA., FarmerK., MacDonaldL., KalshekerN., PritchardD., HaslettC., LambJ., & SallenaveJ-M. (2003). House dust mite Der p1 downregulates defences of the lung by inactivating elastase inhibitors. American Journal of Respiratory Cell and Molecular Biology29, 381–389.
190.
Peters-GoldenM. (2004). The alveolar macrophage: the forgotten cell in asthma. American Journal of Cell and Molecular Biology31, 3–7.
191.
Van RijtL.S., JungS., KleinjanA., VosN., WillartM., DuezC., HoogstedenH.C., & LambrechtB.N. (2005). In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. Journal of Experimental Medicine201, 981–991.
192.
ValstarD.L., SchijfM.A., ArtsJ.H., KuperC.F., NijkampF.P., StormG., BloksmaN., & HenricksP.A. (2006). Alveolar macrophages suppress nonspecific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albumin. Archives of Toxicology80, 561–571.
193.
ValstarD.L., SchijfM.A., StelekatiE., NijkampF.P., StormG., BloksmaN., & HenricksP.A. (2006). Trimellitic anhydride-conjugated serum albumin activates rat alveolar macrophages in vitro.Journal of Occupational Medicine and Toxicology23, 1–13.