KoëterH.B.W.M., & VisserR. (2000). Work in OECD on chemical safety: approaches for human risk assessment. Industrial Health38, 109–119.
2.
CombesR.D., GauntI., & BallsM. (2004). A scientific and animal welfare assessment of the OECD Health Effects Test Guidelines for the safety testing of chemicals under the European Union REACH system. ATLA32, 163–208.
3.
Health Council of the Netherlands (2001). Toxicity Testing: A More Efficient Approach. Publication no. 2001/24E, 70 pp. The Hague, The Netherlands: Health Council of the Netherlands. Website http://www.gr.nl/adviezen.php?jaar=2001 (Accessed 02.07.05).
4.
IllingH.P. (2006). General overview of the safety evaluation of chemicals. In Alternatives to Animal Testing (ed. HesterR.E., & HarrisonR.M.), pp. 1–27. Cambridge, UK: RSC Publishing.
5.
IllingH.P. (2001). Toxicity and Risk — Context, Principles and Practice.168 pp. Basingstoke, Hants., UK: Taylor and Francis.
6.
European Commission (2003). Proposal for a Regulation of the European Parliament and of the Council Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Establishing a European Chemicals Agency and Amending Directive 1999/45/EC and Regulation (EC) {on persistent Organic Pollutants} and Proposal for a Directive of the European Parliament and on the Council Amending Council Directive 67/548/EEC in Order to Adapt it to Regulation (EC) of the European Parliament and on the Council Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals, COM(2003) 644 final. 158 pp. Brussels, Belgium: European Commission. Website http://europa.eu.int/eur-lex/en/com/pdf/2003/com2003_0644en.html (Accessed 02.02.06).
7.
Anon. (1999). Risk Assessment Approaches Used by UK Government for Evaluating Human Health Effects of Chemicals.57 pp. Leicester, UK: Institute for Environment & Health.
8.
RenwickA.G., BarlowS.M., Hertz-PicciottoI., BoobisA.R., DybingE., EdlerL., EisenbrandG., GreigJ.B., KleinerJ., LambeJ., MullerD.J.G., SmithM.R., TritscherA., TuijtelaarsS., BrandtP.A.V.D., WalkerR., & KroesR. (2003). Risk characterisation of chemicals in food and diet. Food and Chemical Toxicology41, 1211–1271.
9.
Anon. (2004). Targeted Risk Assessment. ECETOC Technical Report 93, 228 pp. Brussels, Belgium: European Centre for Ecotoxicology and Toxicology of Chemicals.
10.
WHO (1994). Assessing Human Health Risks of Chemicals: Derivation of Guidance Values for Health Based Limits. Environmental Health Criteria, No. 170. Geneva, Switzerland: World Health Organisation.
11.
KnightD.J., & ThomasM.B. (2003). Practical Guide to Chemical Safety Testing.448 pp. Shawbury, UK: Rapra Technology Ltd.
12.
SetzerR.W., & KimmelC.A. (2003). Use of NOAEL, Benchmark dose, and other models for human risk assessment of hormonally active substances. Applied Chemistry75, 2151–2158.
13.
Anon. (2003). Uncertainty Factors: Their Use in Human Health Risk Assessment by the UK Government.68 pp. Leicester, UK: The Interdepartmental Group on Health Risks from Chemicals, MRC Institute for Environment and Health.
14.
RenwickA.G. (1993). Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Additives Contaminants10, 275–305.
15.
Anon. (1999). From Risk Assessment to Risk Management: Dealing with Uncertainty.31 pp. Leicester, UK: The Interdepartmental Group on Health Risks from Chemicals, MRC Institute for Environment and Health.
16.
IllingH.P.A. (2006). Risk management. In Fundamental Toxicology (ed. DuffusJ.H., & WorthH.G.J.), pp. 72–97. Cambridge, UK: Royal Society of Chemistry.
17.
Anon. (1999). Developing New Approaches to Assessing Risk to Human Health from Chemicals.21 pp. Leicester, UK: The Interdepartmental Group on Health Risks from Chemicals, MRC Institute for Environment and Health.
18.
Anon. (2004). Making Sense of Risk.24 pp. London, UK: CTPA.
19.
Anon. (2003). The Future of Risk Assessment in the European Union – The Second Report on the Harmonisation of Risk Assessment Procedures. Adopted by the Scientific Steering Committee at its Meeting of 10–11 April 2003. 95 pp. Brussels, Belgium: European Commission.
Anon. (2003). Proposal for a Regulation of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Establishing a European Chemicals Agency and amending Directive 1999/45/ec and Regulation (EC) {on Persistent Organic Pollutants}. COM(2003) 644 final. Brussels, Belgium: European Commission.
22.
GrindonC., BhogalN., CombesR., & BallsM. (2005). The scientific, animal welfare and regulatory implications of the EU REACH system for chemical safety. Regulatory Rapporteur2, 16–22.
23.
GrindonC., & CombesR. (2006). Introduction to the EU REACH Legislation. ATLA34, Suppl. 1, 5–10.
Anon. (2006). Guidelines on Route-to-Route Extrapolation of Toxicity Data When Assessing Health Risks of Chemicals.56 pp. Cranfield, UK: The Interdepartmental Group on Health Risks from Chemicals, MRC Institute for Environment and Health.
CalabreseE.J., & BaldwinL.A. (1994). Improved method for selection of the NOAEL. Regulatory Pharmacology and Toxicology19, 48–50.
28.
LovellD. (1993). Risk Assessment of Chemicals. In Experimental Toxicology — The Basic Issues (ed. AndersonD., & ConningD.M.), pp. 442–463. Cambridge, UK: Royal Society of Chemistry, Cambridge.
29.
RenwickA.G. (1995). The use of an additional safety or uncertainty factor for nature of toxicity in the estimation of acceptable daily intake and tolerable daily intake values. Regulatory Pharmacology and Toxicology22, 250–261.
30.
RenwickA.G., DorneJ.L., & WaltonK. (2000). An analysis of the need for an additional uncertainty factor for infants and children. Regulatory Pharmacology and Toxicology31, 286–296.
31.
International Programme on Chemical Safety (2005). Chemical-specific Adjustment Factors for Interspecies Differences and Human Variability. Guidance Document for Use of Data in Dose/concentration–response Assessment. Harmonization Project Document Number 2. Geneva, Switzerland: IPCVS. Website http://whqlibdoc.who.int/publications/2005/9241546786_eng.pdf (Accessed 15.06.06).
32.
CombesR., BallsM., BansilL., BarrattM., BellD., BothamP., BroadheadC., ClothierR., GeorgeE., FentemJ., JacksonM., IndansI., LaozouG., NavaratnamV., PentreathV., PhillipsB., StemplewskiH., & StewartJ. (2002). An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the Second FRAME Toxicity Committee (1991). ATLA30, 365–406.
WorthA.P., & BallsM. eds (2002). Alternative (non-animal) methods for chemicals testing: current status and future prospects. A report prepared by ECVAM and the ECVAM Working Group on Chemicals. ATLA30, Suppl. 1, 1–125.
35.
KnightD.J., & BrehenyD. (2002). Alternatives to animal testing in the safety evaluation of products. ATLA30, 7–22.
36.
MitchellI. de G., & CombesR.D. (1997). In vitro genotoxicity and cell transformation assessment. In In vitro Methods in Pharmaceutical Research, (ed. CastellJ.V., & Gómez-LechónM. J.), pp. 318–352. London, UK & New York, NY, USA: Academic Press Ltd.
37.
ChamberlainM., & ParishW.E. (1990). Hazard and risk based on in vitro test data. Toxicology in Vitro4, 694–697.
PrietoP., BairdA.W., BlaauboerB.J., Castell RipollJ.V., CorviR., DekantW., DietlP., GennariA., GribaldoL., GriffinJ.L., HartungT., HeindelJ.J., HoetP., JenningsP., MarocchioL., NorabergJ., PazosP., WestmorelandC., WolfA., WrightJ., & PfallerW. (2006). The assessment of repeated dose toxicity in vitro: a proposed approach. The Report and Recommendations of ECVAM Workshop 56. ATLA34, 315–341.
40.
Anon. (2004). Opinion of the Scientific Committee on Toxicity, Ecotoxicity and the Environment (CSTEE) on the BUAV-ECEAE Report on The Way Forward — Action to End Animal Toxicity Testing. C7/VR/csteeop/anat/o8o104 D(04). 20 pp. Brussels, Belgium: European Commission.
41.
GreimH., ArandM., AutrupH., BoltH., BridgesJ., DybingE., GlomotR., FoaV., & Schulte-HermannR. (2006). Toxicological comments to the discussion about REACH. Archives of Toxicology13, 1–4.
42.
JohannsenF.R. (1990). Risk assessment of carcinogenic and non-carcinogenic chemicals. Critical Reviews of Toxicology20, 341–367.
43.
International Programme on Chemical Safety (1999). Principles For the Assessment of Risks to Human Health from Exposure to Chemicals. Environmental Health Criteria No. 210. Geneva, Switzerland: IPCS.
44.
Brendler-SchwaabS.Y., SchmezerP., LiegibelU., WeberS., MichalekK., TompaA., & Pool-ZobelB.L. (1994). Cells of different tissues for in vitro and in vivo studies in toxicology: Compilation of isolation methods. Toxicology in Vitro8, 1285–1302.
45.
CoeckeS., AhrH., BlaauboerB.J., BremerS., CasatiS., CastellJ., CombesR., CorviR., CrespiC.L., CunninghamM.L., ElautG., ElettiB., FreidigA., GennariA., Ghersi-EgeaJ-F., GuillouzoA., HartungT., HoetP., Ingelman-SundbergM., MunnS., JassensW., LadstetterB., LeahyD., LongA., MeneguzA., MonshouwerM., MorathS., NagelkerkeF., PelkonenO., PontiJ., PrietoP., RichertL., SabbioniE., SchaackB., SteiliingW., TestaiE., VericatJ-A., & WorthA. (2006). Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM Workshop 54. ATLA34, 49–84.
46.
KahnC.R., YoungE., LeeI.H., & RhimJ.S. (1993). Human corneal epithelial primary cultures and cell lines with extended life span: In vitro model for ocular studies. Investigative Ophthalmology and Visual Science34, 3429–3441.
47.
EltonR.C., RhodesP., & FryJ.R. (1999). Evaluation of a short-term rat proximal tubule incubation system for the detection of nephrotoxicants. ATLA27, 433–448.
48.
OrrS., AlexandreE., ClarkB., CombesR., FelsL.M., GrayN., Jensson-RylanderA-C., HelinH., KoistinenJ., OinonenT., RichertL., RavidR., SalonenJ., TeesaluT., ThaslerW., TraffordJ., van der ValkJ., von VersenR., WeissT., WomackC., & YlikomiT. (2002). The establishment of a network of European human research tissue banks. Cell and Tissue Banking3, 133–137.
49.
CombesR.D. (2004). The use of human cells in biomedical research and testing. ATLA32, Suppl. 1, 43–49.
50.
BhogalN., GrindonC., CombesR., & BallsM. (2005). Toxicity testing: creating a revolution based on new technologies. Trends in Biotechnology23, 299–307.
51.
AtterwillC.K., GoldfarbP., & PurcellW. eds. (2000). Approaches to High Throughput Toxicity Screening.200 pp. London, UK: Taylor & Francis.
52.
CorviR., AhrH-J., AlbertiniS., BlakeyD.H., ClericiL., CoeckeS., DouglasG.R., GribaldoL., GrotenJ.P., HaaseB., HamernikK., HartungT., InoueT., IndansI., MauriciD., OrphanidesG., RembgesD., SansoneS-A., SnapeJ.R., TodaE., TongW., van DelftJ.H., WeisB., & SchechtmanL.M. (2005). Validation of Toxicogenomics-Based Test Systems: ECVAM-ICCVAM/NICETAM Considerations for Regulatory Use. Environmental Health Perspectives114, 420–429.
53.
LeightonJ.K. (2005). Application of emerging technologies in toxicology and safety assessment: regulatory perspectives. International Journal of Toxicology24, 153–155.
54.
AardemaM., & MacGregorJ.T. (2002). Toxicology and genetic toxicology in the new era of “toxicogenomics”: impact of “omics” technologies. Mutation Research499, 13–25.
55.
FentemJ., ChamberlainM., & SangsterB. (2004). The feasibility of replacing animal testing for assessing consumer safety: A suggested future direction. ATLA32, 617–623.
56.
SobelsF.H. (1980). Evaluating the mutagenic potential of chemicals: the minimal battery and extrapolation problems. Archives of Toxicology46, 21–30.
57.
SutterT.R. (1995). Molecular and cellular approaches to extrapolation for risk assessment. Environmental Health Perspectives103, 386–389.
58.
van RavenzwaayB., & LeiboldE. (2004). The significance of in vitro rat skin absorption studies to human risk assessment. Toxicology in Vitro18, 219–225.
59.
PessinaA., AlbellaB., BayoM., BuerenJ., BrantomP., CasatiS., CroeraC., ParchmentR., Parent-MassinD., SchoetersG., SibiriY., Van Den HeuvelR., & GribaldoL. (2002). In vitro tests for haematotoxicity: Prediction of drug-induced myelo-suppression by the CFU-GM assay. ATLA30, Suppl. 275–279.
60.
Anon. (1999). Physiologically-Based Pharmacokinetic Modelling: A Potential Tool for Use in Risk Assessment.31 pp. Leicester, UK: The Interdepartmental Group on Health Risks from Chemicals, MRC Institute for Environment and Health.
61.
DashwoodR.H., CombesR.D., & AshbyJ. (1987). On the lack of specificity of the Salmonella mutagenicity assay. Mutagenesis2, 301.
62.
DashwoodR.H., & CombesR.D. (1987). The use of in vivo-like concentrations of chemicals for validation of in vitro short-term genotoxicity assays — an in vivo equivalent dose concept. Mutagenesis2, 249–251.
63.
SambuyY., De AngelisI., RanaldiG., ScarinoM.L., StammatiA., & ZuccoF. (2005). The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biology and Toxicology21, 1–26.
64.
HanuR., McKennaM., O'NeillA., ResneckW.G., & BlochR.J. (2000). Monocarboxylic acid transporters, MCT1 and MCT2, in cortical astrocytes in vitro and in vivo.American Journal of Physiology– Cell Physiology278, C921–C930.
65.
YeeS., & DayW.W. (1999). Application of Caco-2 cells in drug discovery and development. In Handbook of Drug Metabolism (ed. WoolfT.F.), pp. 507–522. New York, NY, USA: Marcel Dekker Inc.
66.
CombesR.D. (2005). Assessing risk to humans from chemical exposure by using non-animal test data. Toxicology in Vitro19, 921–924.
67.
FrazierJ.M. (2004). A theoretical model for simulating the outcome of mechanism based in vitro toxicity testing strategies. Toxicology in Vitro18, 171–178.
68.
SidoliF.R., MantalarisA., & AspreyS.P. (2004). Modelling of mammalian cells and cell culture processes. Cytotechnology44, 27–46.
69.
Anon. (2001). Biomarkers. In Risk Assessment: Validity And Validation, Environmental Health Criteria 222. Geneva, Switzerland: WHO. Website http://www.inchem.org/documents/ehc/ehc/ehc222.htm (Accessed 12.07.06).
70.
BlaauboerB.J. (2002). The applicability of in vitro-derived data in hazard identification and characterisation of chemicals. Environmental Toxicology and Pharmacology11, 213–225.
GüldenM., & SeibertH. (1997). Influence of protein binding and lipophilicity on the distribution of chemical compounds in in vitro systems. Toxicology in Vitro11, 479–483.
73.
GüldenM., MörchelS., & SeibertH. (2001). Factors influencing nominal effective concentrations of chemical compounds in vitro: cell concentration. Toxicology in Vitro15, 233–243.
74.
GüldenM., MörchelS., TahanS., & SeibertH. (2002). Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro.Toxicology175, 201–213.
75.
GüldenM., & SeibertH. (2003). In vitro–in vivo extrapolation: estimation of human serum concentrations of chemicals equivalent to cytotoxic concentrations in vitro.Toxicology189, 211–222.
76.
GüldenM., MörchelS., & SeibertH. (2003). Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay. Toxicology Letters137, 159–168.
77.
SeibertH., MörchelS., & GüldenM. (2002). Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration. Toxicology in Vitro16, 289–297.
78.
HeringaM.B., SchreursR.H.M.M., BusserF., Van der SaagP.T., Van der BurgB., & HermensJ.L.M. (2004). Toward more useful in vitro toxicity data with measured free concentrations. Environmental Science & Technology38, 6263–6270.
79.
GüldenM., & SeibertH. (2006). In vitro–in vivo extrapolation of toxic potencies for hazard and risk assessment — problems and new developments. ALTEX23, Special Issue, 218–225.
80.
GüldenM., DierickxP., & SeibertH. (2006). Validation of a prediction model for estimating serum concentrations of chemicals which are equivalent to toxic concentrations in vitro.Toxicology in Vitro20, 114–1124.
81.
GüldenM., & SeibertH. (2005). Impact of bioavailability on the correlation between in vitro cytotoxic and in vivo acute fish toxic concentrations of chemicals. Aquatic Toxicology72, 327–337.
82.
TreijtelN., BarendregtA., FreidigA.P., BlaauboerB.J., & van EijkerenJ.C. (2004). Modelling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich cultured rat hepatocytes. Drug Metabolism and Disposition32, 884–891.
83.
TreijtelN., van HelvoortH., BarendregtA., BlaauboerB.J., & van EijkerenJ.C.H. (2005). The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-ethoxycoumarin and warfarin. Drug Metabolism and Disposition33, 1325–1332.
84.
DeglmannC.J., EbnerT., LudwigE., HappichS., SchildbergF.W., & KoebeH.G. (2004). Protein binding capacity in vitro changes metabolism of substrates and influences the predictability of metabolic pathways in vivo.Toxicology in Vitro18, 835–840.
85.
Gubbels-van HalW.M.L.G., BlaauboerB.J., BarentsenH.M., HoitinkM.A., MeertsI.A.T.M., & van der HoevenJ.C.M. (2005). An alternative approach for the safety evaluation of new and existing chemicals, an exercise in integrated testing. Regulatory Toxicology & Pharmacology42, 284–295.
86.
DeJonghJ., ForsbyA., HoustonJ.B., BeckmanM., CombesR., & BlaauboerB.J. (1999). An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological in vitro test methods: overview of a prevalidation study based on the ECITTS project. Toxicology in Vitro13, 549–554.
87.
FielderR., AtterwillC.K., AndersonD., BoobisA.R., BothamP., ChamberlainM., CombesR., DuffeyP.A., LewisR.W., LumleyC.E., KimberI., & NewallD.R. (1997). British Toxicology Society (BTS) working party report on in vitro toxicology. Human and Experimental Toxicology16, S1–S40.
88.
EskesC., & ZuangV., eds. (2005). Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects. A Report Prepared in the Context of the 7th Amendment of the Cosmetics Directive for Establishing the Timetable for Phasing Out Animal Testing. ATLA33, Suppl. 1, 1–228.
FaustmanE.M., PonceR.A., OuY.C., MendozaM.A.C., LewandowskiT., & KavanaghT. (2002). Investigations of methylmercury-induced alterations in neurogenesis. Environmental Health Perspectives110, 859–864.
91.
LewandowskiT.A., PonceR.A., BartellS.M., & FaustmanE.M. (2000). Comparison of developmental toxicity of methylmercury in vitro and in vivo: potential value of in vitro-derived data for dose– response assessment. Society for Risk Analysis Annual Meeting, Arlington, VA, December. Website www.riskworld.com/Abstract/2000/SRAam00/ab0ac198.htm (Accessed 12.02.06).
92.
VerweiM., van BurgstedenJ.A., KrulC.A.M., van de SandtJ.J.M., & FreidigA.P. (2006). Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling. Toxicology Letters165, 78–79.
93.
GenschowE., SpielmannH., ScholzG., SeilerA., BrownN.A., PiersmaA., BradyM., ClemannN., HuuskonenH., PaillardF., BremerS., & BeckerK. (2002). The ECVAM international validation study on in vitro embryotoxicity tests. Results of the definitive phase and evaluation of prediction models. ATLA30, 151–176.
94.
ChamberlainM. (1996). A risk assessment paradigm. Cited in Final Report of the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods (slides available from the OECD Secretariat). Paris, France: OECD.
95.
ConnorA.H., LorenzL.F., & HirthK.C. (2002). Accelerated cure of phenol-formaldehyde resins: studies with model compounds. Journal of Appied Polymer Science86, 3256–3263.
96.
International Programme on Chemical Safety (1996). Morpholine. Environmental Health Criteria 179. UNEP-ILO-WHO International Program on Chemical Safety.Geneva, Switzerland: IPCS.
97.
FromsonJ.M., IllingH.P.A., IngsR.M.J., JohnsonK.I., JohnsonP., OstrowskiJ., SchravenE., & StewardA. (1981). Absorption and disposition of [14C]-molsidomine in laboratory animals. Arzneim Forschung31, 337–345.
98.
WilsonI.D., WatsonK.V., TrokeJ., IllingH.P.A., & FromsonJ. (1986). The metabolism of [14C]-N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) in laboratory animals. Xenobiotica16, 1117–1128.
99.
WilsonI.D., FromsonJ.M., & IllingH.P.A. (1987). The metabolism of [14C]-N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) in man. Xenobiotica17, 93–104.
100.
TimbrellJ.A. (2000). Biotransformation of xenobiotics. In General and Applied Toxicology, Second Edition, (ed. BallantyneB., MarrsT., & SyversenT., 2nd edn, pp. 97–124. Basingstoke, Hants., UK: Macmillan.
101.
LehmanA.J., & FitzhughO.G. (1954). 100 fold margin of safety. Quarterly Bulletin of the Association Food and Drug Officials18, 33–35.
102.
Anon. (1999). Risk Assessment Approaches Used by UK Government for Evaluating Human Health Effects of Chemicals.57 pp. Leicester, UK: Institute for Environment & Health.
103.
RenwickA.G. (1993). Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Additives Contaminants10, 275–305.
104.
IllingH.P.A. (2006). General overview of the safety evaluation of chemicals. In Alternatives to Animal Testing (ed. HesterR.E., & HarrisonR.M), pp. 1–27. Cambridge, UK: Royal Society of Chemistry.
105.
BhogalN., & CombesR. (2006). The UK Food Standards Agency Draft Report on Variability and Uncertainty in Toxicology: A response by FRAME. ATLA34, 539–544.
106.
GüldenM., MörchelS., & SeibertH. (2001). Factors influencing nominal effective concentrations of chemical compounds in vitro: cell concentration. Toxicology in Vitro15, 233–243.
107.
SeibertH., MörchelS., & GüldenM. (2002). Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration. Toxicology in Vitro16, 289–297.
108.
GüldenM., & SeibertH. (1997). Influence of protein binding and lipophilicity on the distribution of chemical compounds in in vitro systems. Toxicology in Vitro11, 479–483.
109.
GüldenM., MörchelS., & SeibertH. (2003). Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay. Toxicology Letters137, 159–168.
110.
GüldenM., MörchelS., TahanS., & SeibertH. (2002). Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro.Toxicology175, 201–213.
111.
GüldenM., & SeibertH. (2003). In vitro–in vivo extrapolation: estimation of human serum concentrations of chemicals equivalent to cytotoxic concentrations in vitro.Toxicology189, 211–222.
112.
GüldenM., & SeibertH. (2005). Impact of bioavailability on the correlation between in vitro cytotoxic and in vivo acute fish toxic concentrations of chemicals. Aquatic Toxicology72, 327–337
113.
GüldenM., & SeibertH. (2006). In vitro–in vivo extrapolation of toxic potencies for hazard and risk assessment — Problems and new developments. ALTEX23 Special Issue, 218–225.
114.
GüldenM., SeibertH., & VossJ.U. (1994). Inclusion of physicochemical data in quantitative comparisons of in vitro and in vivo toxic potencies. ATLA22, 185–192.
115.
GüldenM., & SeibertH. (2003). In vitro–in vivo extrapolation: estimation of human serum concentrations of chemicals equivalent to cytotoxic concentrations in vitro.Toxicology189, 211–222.
116.
GüldenM., DierickxP., & SeibertH. (2006). Validation of a prediction model for estimating serum concentrations of chemicals which are equivalent to toxic concentrations in vitro.Toxicology in Vitro20, 1114–1124.