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Abstract

The EU Physical Agents (EMF) Directive, Directive 2004/40/EC, which threatens to greatly restrict the use of magnetic resonance imaging (MRI) in both clinical and research situations, will come into force on 30 April 2008. This could severely affect experimental animal welfare and scientific progress, as well as patient care. FRAME made a submission to a Health and Safety Executive round-table discussion about the Directive, held in January 2006, detailing concerns about the implications that the legislation would have on implementing the Three Rs in animal-based research and testing, and the subsequent consequences for animal welfare and the quality of scientific output. The submission is reproduced here, with additional comments on the outcome of the meeting and recommendations for further research into the consequences of the Directive.

Keywords

animal experimentation Directive 2004/40/EC magnetic resonance imaging Physical Agents Directive

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References

Anon. (2004). Directive 2004/40/EC of the European Parliament and of the Council of 29 April 2004 on the minimum health and safety requirements regarding the exposure of workers to the risks arising from physical agents (electromagnetic fields). Official Journal of the European Union L159, 1–26. (and corrigenda L184 of 24 May 2004).

Russell

W.M.S.

, & Burch

R.L.

(1959). The Principles of Humane Experimental Technique, 238 pp. London, UK: Methuen.

Hudson

(2005). The welfare and scientific advantages of non-invasive imaging of animals in biomedical research. Animal Welfare 14, 303–317.

Bangard

, Gossmann

, Papyan

, Tawadros

, Hellmich

, & Bruns

C.J.

(2005). Magnetic resonance imaging in an orthotopic rat model: blockade of epidermal growth factor receptor with EMD72000 inhibits human pancreatic carcinoma growth. International Journal of Cancer 114, 131–138.

Huang

, Shan

, Braun

R.D.

, Lanzen

, Anyrhambatla

, Kong

, Borelli

, Corry

, Dewhirst

M.W.

, & Li

C.Y.

(1999). Non-invasive visualization of tumours in rodent dorsal skin window chambers. Nature Biotechnology 17, 1033–1035.

Pogge

, & Slikker

Jr. (2004). Neuroimaging: new approaches for neurotoxicology. Neurotoxicology 25, 525–531.

Dr Hadwen Trust (2005). Current Research Projects 2005. Website http://www.drhadwentrust.f2s.com/J_FS-RP_ResProjects2005.html (Accessed 06.12.05).

Budinger

T.F.

, Benaron

D.A.

, & Koretsky

A.P.

(1999). Imaging transgenic animals. Annual Review of Biomedical Engineering 1, 611–648.

Home Office (2005). Statistics of Scientific Procedures on Living Animals: Great Britain 2004, Cm 6713, 101 pp. London, UK: HMSO.

10.

Langley

, Harding

, Hawkins

, Jones

, Newman

, Swithenby

, Thompson

, Tofts

, & Walsh

(2000). Volunteer studies replacing animal experiments in brain research. ATLA 28, 315–331.

11.

Benveniste

, & Blackband

(2002). MR microscopy and high resolution small animal MRI: applications in neuroscience research. Progress in Neurobiology 67, 393–420.

12.

Giannesini

, Cozzone

P.J.

, & Bendahan

(2004). In vivo MR investigation of skeletal muscle function in small animals. MAGMA 17, 210–218.

13.

McKinlay

A.F.

, Allen

S.G.

, Cox

, Dimbylow

P.J.

, Mann

S.M.

, Muirhead

C.R.

, Saunders

R.D.

, Sienkiewicz

Z.J.

, Stather

J.W.

, & Wainwright

P.R.

(2004). Review of the scientific evidence for limiting exposure to electromagnetic fields (0–300GHz). Documents of the NRPB 15, 1–210.

14.

Anon. (1998). Guidelines for limiting exposure to time-varying electric, magnetic and electromagnetic fields (up to 300GHz). Health Physics 74, 494–522.

15.

Anon. (2005). Alert: The EU Physical Agents Directive and its impact on MRI. Sense about science website http://www.senseaboutscience.org.uk/PDF/BriefingDocument.pdf (Accessed 24.10.05).

16.

CO-SUR (2002). Risk: Improving Government's Capability to Handle Risk and Uncertainty. Cabinet Office Strategy Unit Report — November 2002, London. 135 pp. Website http://www.strategy.gov.uk/downloads/su/RISK/REPORT/downloads/su-risk.pdf (Accessed 17.11.05).

17.

Kemp

R.V.

, & Greulich

(2006). EU EMF Physical Agents Directive EC/40/2004 Implementation into UK Legislation Report of Roundtable Discussions. 19 pp. Rutland, UK: Galson Sciences LTD. Website http://www.hse.gov.uk/radiation/nonionising/notes.pdf (Accessed 28.03.06).

The EU Physical Agents (EMF) Directive and its Impact on MRI Imaging in Animal Experiments: A Submission by FRAME to the HSE

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