BrownN.A., SpielmannH., BechterR., FlintO.P., FreemanR.J., JelinekR.J., KochE., NauH., NewallD.R., PalmerA.K., RenaultJ.Y., RepettoM.F., VogelR., & WigerR. (1995). Screening chemicals for reproductive toxicity: the current alternatives. The report and recommendations of an ECVAM/ETS workshop (ECVAM Workshop 12). ATLA23, 868–882.
2.
Anon. (2003). Proposal Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). COM(2003)644 final. 139 pp. Brussels, Belgium: European Commission. Website http://europa.Eu.int/eur-lex/en/com/pdf/2003/com2003_0644en.html (Accessed 20.12.04).
3.
PedersenF., De BruijnJ., MunnS.J., & van LeeuwenK. (2003). Assessment of additional testing needs under REACH. Effects of (Q)SARs, risk based testing and voluntary industry initiatives. Publication: EUR 20863 EN (2003). 36 pp. Ispra, Italy: Institute of Health & Consumer Protection.
4.
Van der JagtK., MunnS., TørsløvJ., & de BrujinJ. (2004). Alternative approaches can reduce the use of test animals under REACH. Addendum to Assessment of Additional Testing Needs under REACH. Effects of (Q)SARs, Risk Based Testing and Voluntary Industry Initiatives. JRC Report EUR 21405 EN, 25 pp. Ispra, Italy: European Commission Joint Research Centre. Website http://ecb.jrc.it (Accessed 16.3.05).
5.
Anon. (2003). Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products (Text with EEA relevance). Official Journal of the European UnionL66, 26–35.
6.
ChoudhuryA.R. (2003). Effect of industrial chemicals on male reproductive organ. Toxicology15, 29–30.
7.
BarchielliA., BurattiE., FranchiniM., GeddesM., & ScarselliG. (1982). Male infertility and occupational exposure to chemical agents: a review. La Medicina del lavoro73, 483–95.
8.
MangelsdorfI., BuschmannJ., & OrthenB. (2003). Some aspects relating to the evaluation of the effects of chemicals on male fertility. Regulatory Toxicology and Pharmacology37, 356–369.
9.
OngC.N., ShenH.M., & ChiaS.E. (2002). Bio-markers for male reproductive hazards: are they available?Toxicology Letters134, 17–30.
10.
BondeJ.P., & StorgaardL. (2002). How workplace conditions, environmental toxicants and lifestyle affect male reproductive function. International Journal of Andrology25, 262–268.
11.
Anon. (2001). General Guidelines for Submitting a Proposal to ECVAM for the Evaluation of the Readiness of a Test Method to Enter the ECVAM Prevalidation and/or Validation Process. Website http://ecvam.jrc.it/index.htm (Accessed 13.4.05).
12.
GalliC., VassilievI., LagutinaI., GalliA., & LazzariG. (2003). Bovine embryo development following ICSI: effect of activation, sperm capacitation and pre-treatment with dithiothreitol. Theriogenology60, 1467–80.
13.
CortvrindtR.G., & SmitzJ.E. (2002). Follicle culture in reproductive toxicology: a tool for in vitro testing of ovarian function?Human Reproduction Update8, 243–254.
14.
HuY., CortvrindtR., & SmitzJ. (2002). Effects of aromatase inhibition on in vitro follicle and oocyte development analysed by early preantral mouse follicle culture. Molecular Reproduction and Development61, 549–559.
15.
CortvrindtR., HuY., LiuJ., & SmitzJ. (1998). A timed analysis of the nuclear maturation of oocytes in recombinant gonadotropin-supplemented early preantral mouse follicle culture. Fertility and Sterility70, 1114–1125.
16.
SunF., BetzendahlI., ShenY., CortvrindtR., SmitzJ., & Eichenlaub-RitterU. (2004). Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes. Mutagenesis19, 13–25.
17.
KananenK., MarkkulaM., RainioE., SuJ.G., HsuehA.J.W., & HuhtaniemiI.T. (1995). Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin α-subunit promoter/Simian Virus Tantigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines. Molecular Endocrinology9, 616–627.
18.
RilianawatiK.K., RahmanN.A., & HuhtaniemiI. (1999). Hormonal regulation of proliferation of granulosa and Leydig cell lines derived from gonadal tumors of transgenic mice expressing the murine inhibin α-subunit promoter/simian virus 40 virus T-antigen fusion gene. Molecular and Cellular Endocrinology149, 9–17.
19.
AndersonD., DobrzynskaM.M., & BasaranN. (1997). Effect of various genotoxins and reproductive toxins in human lymphocytes and sperm in the Comet assay. Teratogenesis, Carcinogenesis, and Mutagenesis17, 29–43.
20.
LarsenL., ScheikeT., JensenT.K., BondeJ.P., ErnstE., HjollundN.H., ZhouY., SkakkebaekN.E., & GiwercmanA. (2000). Computer-assisted semen analysis parameters as predictors for fertility of men from the general population. The Danish First Pregnancy Planner Study Team. Human Reproduction15, 1562–1567.
21.
SpanoM., BondeJ.P., HjollundH.I., KolstadH.A., CordelliE., & LeterG. (2000). Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team. Fertility and Sterility73, 43–50.
22.
PerreaultS.D. (1998). Gamete toxicology: the impact of new technologies. In Reproductive and Developmental Toxicology (ed. KorachK.S.), pp. 635–654. Ed. New York, NY, USA: Marcel Dekker.
23.
PerreaultS.D., AitkenR.J., BakerH.W., EvensonD.P., HuszarG., IrvineD.S., MorrisI.D., MorrisR.A., RobbinsW.A., SakkasD., SpanoM., & WyrobekA.J. (2003). Integrating new tests of sperm genetic integrity into semen analysis: breakout group discussion. Advances in Experimental Medicine and Biology518, 253–268.
24.
CookeB.A. (1998). In vitro models for the investigation of reproductive toxicology in the testis. Advances in Experimental Medicine and Biology444, 95–102.
25.
StoccoD.M., KingS., & ClarkB.J. (1995). Differential effects of dimethylsulfoxide on steroidogenesis in mouse MA-10 and rat R2C Leydig tumor cells. Endocrinology136, 1918–1926.
26.
WalshL.P., McCormickC., MartinC., & StoccoR.M. (2000). Roundup inhibits steroidogenesis by disrupting steroidogenesis actue regulator (StAR) gene and protein expression. Environmental Health Perspectives108, 769–776.
27.
ToppariJ., & ParvinenM. (1985). In vitro differentiation of rat seminiferous tubular segments from defined stages of the epithelial cycle. Morphologic and immunolocalization analysis. Journal of Andrology6, 334–343.
28.
KuW.W., & ChapinR.E. (1994). Mechanism of the testicular toxicity of boric acid in rats: in vivo and in vitro studies. Environmental Health Perspectives102, 99–105.
29.
AllenbyG., FosterP.M., & SharpeR.M. (1991). Evaluation of changes in the secretion of immunoactive inhibin by adult rat seminiferous tubules in vitro as an indicator of early toxicant action on spermatogenesis. Fundamental and Applied Toxicology16, 710–724.
30.
StaubC., HueD., NicolleJ.C., Perrard-SaporiM.H., SegretainD., & DurandP. (2000). The whole meiotic process can occur in vitro in untransformed rat spermatogenic cells. Experimental Cell Research260, 85–95.
31.
BoekelheideK. (1993). Sertoli cell toxicants. In The Sertoli Cell (ed. RussellL.D., and GriswoldM.D.), pp. 551–575. Clearwater, FL, USA: Cache River Press.
32.
MonseesT.K., FranzM., GebhardtS., WintersteinU., SchillW.B., & HayatpourJ. (2000). Sertoli cells as a target for reproductive hazards. Andrologia32, 239–246.
33.
HewK.W., HeathL., JiwaA.H., & WelshM.J. (1993). Cadmium in vivo causes disruption of tight junction-associated microfilaments in rat Sertoli cells. Biology of Reproduction49, 840–849.
34.
JaneckiA., JakubowliakA., & SteinbergA. (1992). Effect of cadmium chloride on transepithelial electrical resistance of Sertoli cell monolayer in two-compartment cultures: a new model for toxicological investigations of the “blood–testis” barriers in vitro.Toxicology and Applied Pharmacology112, 51–57.
35.
LuiW.Y., LeeW.M., & ChengC.Y. (2001). Trans-forming growth factor-b3 (TGF-b3) perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated its effects on occluding, zonula-occludin-1 and claudin-11. Endocrinology142, 1865–1877.
36.
VecinoP., JoseA., UrangaA.A., & AréchagaJ. (2001). Immortalization of type A spermatogonia using the SV40 Large T Antigen. International Journal of Developmental Biology45, 161–162.
37.
LinD.P., ChangM.Y., ChenB.Y., & ChangH.H. (2003). Male germ line stem cells: from cell biology to cell therapy. Reproduction, Fertility, and Development15, 323–331.
38.
GeijsenN., HoroschakM., KimK., GribnauJ., EgganK., & DaleyG.Q. (2004). Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature, London427, 148–154.
39.
ChoudhuryR.C., GhoshS.K., & PaloA.K. (2001). Potential transmission of the cytogenetic toxic effects of methotrexate in the male germline cells of Swiss mice. Environmental Toxicology and Pharmacology10, 81–88.
40.
ColbyH.D. (1981). Chemical suppression of steroidogenesis. Environmental Health Perspectives38, 119–127.
41.
PhelpsP.V., & LaskeyJ.W. (1989). Comparison of age-related changes in in vitro and in vivo measures of testicular steroidogenesis after acute cadmium exposure in Sprague-dawley rat. Journal of Toxicology and Environmental Health27, 95–105.
42.
GazdarA.F., OieHk, ShackletonC.H., ChenT.R., TricheT.J., MyersC.E., & ChrousosG.P. (1990). Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis. Cancer Research50, 5488–5496.
43.
RaineyW.E., BirdI.M., SawetawanC., HanleyN.A., McCartheyJ.L., McGeeE.A., WesterR., & MasonJ.I. (1993). Regulation of human adrenal carcinoma cell (NCI-H295) production of C19 steroids. Journal of Clinical Endocrinology and Metabolism77, 731–737.
44.
StaelsB., HumD.W., & MillerW.L. (1993). Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal. Molecular Endocrinology7, 423–433.
45.
SandersonJ.T., SeinenW., GiesyJ.P., & van den BergM. (2000). 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?Toxicological Sciences54, 121–127.
46.
SandersonJ.T., SlobbeL., LansbergenG.W., SafeS., & van den BergM. (2001). 2,3,7,8-Tetra-chlorodibenzo-p-dioxin and diindolyomethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicological Sciences61, 40–48.
47.
SandersonJ.T., BoermaJ., LansbergenG.W., & van den BergM. (2002). Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicology and Applied Pharmacology182, 44–54.
48.
HeneweerM., van den BergM., & SandersonJ.T. (2004). A comparison of human H295R and rat R2C cell lines in vitro screening tools for effects on aromatase. Toxicology Letters146, 183–194.
49.
HilscherovaK., JonesP.D., GraciaT., NewstedJ.L., ZhangX., SandersonJ.T., YuR., WuR., & GiesyJ.P. (2004). Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR. Toxicological Sciences81, 78–89.
50.
VinggaardA.M., HnidaC., BreinholtV., & LarsenJ.C. (2000). Screening of selected pesticides for inhibition of CYP19 aromatase activity. Toxicology in Vitro14, 227–234.
51.
SniderC.S., & BrueggemeierR.W. (1987). Potent enzyme-activated inhibition of aromatase by a 7α-substituted C19 steroid. Journal of Biological Chemistry262, 8685–8689.
52.
KellisJ.T., NesnowS., & VickeryL.E. (1986). Inhibition of aromatase cytochrome P450 by derivatives of alpha-napthoflavone. Biochemical Pharmacology35, 2887–2891.
53.
Le BailJ.C., PougetC., FagnereC., BasleyJ.P., ChuliaA.J., & HabriouxG. (2001). Chalcones are potent inhibitors of aromatase and 17-β-dehydrogenanse activity. Life Sciences68, 751–761.
54.
RosenfeldC.S., RobertsR.M., & LubahnD.B. (2001). Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus. Molecular Reproduction and Development59, 336–346.
55.
WatanabeH., SuzukiA., KobayashiM., TakahashiE., ItamotoM., LubahnD.B., HandaH., & IguchiT. (2003). Analysis of temporal changes in the expression of estrogen-regulated genes in the uterus. Journal of Molecular Endocrinology30, 347–358.
56.
BrinkmannA., JensterG., Ris-StalpersC., Van der KorputH., BruggenwirthH., BoehmerA., & TrapmanJ. (1996). Molecular basis of androgen insensitivity. Steroids61, 172–5.
57.
SatoT., MatsumotoT., YamadaT., WatanabeT., KawanoH., & KatoS. (2003). Late onset of obesity in male androgen receptor-deficient (AR KO) mice. Biochemical and Biophysical Research Communications300, 167–71.
58.
LeglerJ., van den BrinkC.E., BrouwerA., MurkA.J., van der SaagP.T., VethaakA.D., & van der BurgB. (1999). Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicological Sciences48, 55–66.
KuiperG., LemmonJ., CarlssonB., CortonJ.C., SafeS., Van Der SaagP., Van Der BurgB., & GustafssonJ. (1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology139, 4252–4268.
61.
GrayL.E., OstbyJ., CooperR.L., & KelceW.R. (1999). The estrogenic and antiandrogenic pesticide methoxychlor alters the reproductive tract and behaviour without affecting pituitary size or LH and prolactin secretion in male rats. Toxicology and Industrial Health15, 37–47.
62.
MonossonE., KelceW.R., LambrightC., OstbyJ., & GrayL.E. (1999). Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the male rat. Toxicology and Industrial Health15, 65–79.
63.
LawsS.C., CareyS.A., FerrellJ.M., BodmanG.L., & CooperR.L. (2000). Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicological Sciences54, 154–167.
64.
BoockforF.R., & BlakeC.A. (1997). Chronic administration of 4-tert-octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. Biology of Reproduction57, 267–77.
65.
SchraderS.M., TurnerT.W., & RatcliffeJ.M. (1988). The effects of ethylene dibromide on semen quality: a comparison of short-term and chronic exposure. Reproductive Toxicology2, 191–198.
66.
CooperR.L., GoldmanJ.M., & StokerT.E. (1999). Neuroendocrine and reproductive effects of con-temporary-use pesticides. Toxicology and Industrial Health15, 26–36.
67.
MeistrichM.L., WilsonG., PorterK.L., HuhtaniemiI., ShettyG., & ShuttlesworthG.A. (2003). Restoration of spermatogenesis in dibromochloropropane (DBCP)-treated rats by hormone suppression. Toxicological Sciences76, 418–426.
68.
WhortonD., MilbyT.H., KraussR.M., & StubbsH.A. (1979). Testicular function in DBCP exposed pesticide workers. Journal of Occupational Medicine21, 161–1616.
69.
HessR.A., LinderR.E., StraderL.F., & PerreaultS.D. (1988). Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat. II. Quantitative and qualitative histopathology of the testis. Journal of Andrology9, 327–342.
70.
LinderR.E., KlinefelterG.R., StraderL.F., NarotskyM.G., SuarezJ.D., RobertsN.L., & PerreaultS.D. (1995). Dibromoacetic acid affects reproductive competence and sperm quality in the male rat. Fundamental and Applied Toxicology28, 9–17.
71.
SaksenaS.K., & LauI.F. (1979). Effects of cadmium chloride on testicular steroidogenesis and fertility of male rats. Endokrinologie74, 6–12.
72.
AndersonD., DobrzynskaM.M., & BasaranN. (1997). Effect of various genotoxins and reproductive toxins in human lymphocytes and sperm in the Comet assay. Teratogenesis, Carcinogenesis and Mutagenesis17, 29–43.
73.
AndersonD., DobrzynskaM.M., YuT.W., GandiniL., CordelliE., & SpanoM. (1997). DNA integrity in human sperm. Teratogenesis, Carcinogenesis and Mutagenesis17, 97–102.
74.
AndersonD., DobrzynskaM.M., BasaranN., BasaranA., & YuT.W. (1998). Flavonoids modulate comet assay responses to food mutagens in human lymphocytes and sperm. Mutation Research18, 269–277.
75.
AndersonD., SchmidT.E., BaumgartnerA., Cemeli-CarratalaE., BrinkworthM.H., & WoodJ.M. (2003). Oestrogenic compounds and oxidative stress in human sperm and lymphocytes in the Comet assay. Mutation Research544, 173–178.
76.
KamiguchiY., & TatenoH. (2002). Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa. Mutation Research25, 183–191.
77.
KamiguchiY., TatenoH., IizawaY., & MikamoK. (1995). Chromosome analysis of human spermatozoa exposed to antineoplastic agents in vitro.Mutation Research326, 185–192.
78.
WyrobekA.J., GordonL.A., BurkhartJ.G., FrancisM.W., KappR.W., LetzG., MallingH.V., TophamJ.C., & WhortonM.D. (1983). An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research115, 1–72.
79.
WyrobekA.J., GordonL.A., BurkhartJ.G., FrancisM.W., KappR.W., LetzG., MallingH.V., TophamJ.C., & WhortonM.D. (1983). An evaluation of human sperm as indicators of chemically induced alterations of spermatogenic function. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research115, 73–148.
80.
EvensonD.P., BaerR.K., JostL.K., & GeschR.W. (1986). Toxicity of thiotepa on mouse spermatogenesis as determined by dual-parameter flow cytometry. Toxicology and Applied Pharmacology82, 151–163.
81.
EvensonD.P., JancaF.C., & JostL.K. (1987). Effects of the fungicide methyl-benzimidazol-2-yl carbamate (MBC) on mouse germ cells as determined by flow cytometry. Journal of Toxicology and Environmental Health20, 387–399.
82.
EvensonD.P., BaerR.K., & JostL.K. (1989). Long-term effects of triethylenemelamine exposure on mouse testis cells and sperm chromatin structure assayed by flow cytometry. Environmental and Molecular Mutagenesis14, 79–89.
83.
EvensonD.P., JancaF.C., BaerR.K., JostL.K., & KarabinusD.S. (1989). Effect of 1,3-dinitrobenzene on prepubertal, pubertal, and adult mouse spermatogenesis. Journal of Toxicology and Environmental Health28, 67–80.
84.
EvensonD.P., JancaF.C., JostL.K., BaerR.K., & KarabinusD.S. (1989). Flow cytometric analysis of effects of 1,3-dinitrobenzene on rat spermatogenesis. Journal of Toxicology and Environmental Health28, 81–98.
FosterW.G., McMahonA., & RiceD.C. (1996). Sperm chromatin structure is altered in cynomolgus monkeys with environmentally relevant blood lead levels. Toxicology and Industrial Health12, 723–735.
89.
Hacker-KlomU.B., MeistrichM.L., & GöhdeW. (1986). Effect of doxorubicin and 4’-epi-doxorubicin on mouse spermatogenesis. Mutation Research160, 39–46.
90.
HooverD.M., HoytJ.A., SeylerD.E., AbbottD.L., HoffmanW.P., & BueningM.K. (1991). Comparative effects of disulfiram and N-methyltetrazolethiol on spermatogenic development in young CD rats. Toxicology and Applied Pharmacology107, 164–172.
91.
IidaS., MisakaH., & NayaM. (1997). A flow cytometric analysis of cytotoxic effects of nitrobenzene on rat spermatogenesis. Journal of Toxicological Sciences22, 397–407.
92.
JagetiaG.C., KrishnamurthyH., & JyothiP. (1996). Evaluation of cytotoxic effects of different doses of vinblastine on mouse spermatogenesis by flow cytometry. Toxicology112, 227–236.
93.
JagetiaG.C., JyothiP., & KrishnamurthyH. (1997). Flow cytometric evaluation of the effect of various doses of vindesine sulphate on mouse spermatogenesis. Reproductive Toxicology11, 867–874.
94.
JyothiP., JagetiaG.C., & KrishnamurthyH. (2001). Evaluation of teniposide (VM-26)-induced toxicity on mouse spermatogenesis by flow cytometry. Toxicology163, 163–174.
95.
KatohC., KitajimaS., SagaY., KannoJ., HoriiI., & InoueT. (2002). Assessment of quantitative dual-parameter flow cytometric analysis for the evaluation of testicular toxicity using cyclophosphamide- and ethinylestradiol-treated rats. Journal of Toxicological Sciences27, 87–96.
96.
PacchierottiF., TiveronC., D'ArchivioM., BassaniB., CordelliE., LeterG., & SpanoM. (1994). Acrylamide-induced chromosomal damage in male mouse germ cells detected by cytogenetic analysis of one-cell zygotes. Mutation Research309, 273–284.
97.
PacchierottiF., TiveronC., RanaldiR., BassaniB., CordelliE., LeterG., & SpanoM. (1998). Reproductive toxicity of 1,3-butadiene in the mouse: cytogenetic analysis of chromosome aberrations in first-cleavage embryos and flow cytometric evaluation of spermatogonial cell killing. Mutation Research397, 55–66.
98.
ScottC.A., DesinanL., MaffezziniM., SimonatoA., AvelliniC., De StefaniS., RizziV., CarmignaniG., & BeltramiC.A. (1996). Effects of cis-platinum and luteinizing hormone releasing hormone analogues on rat spermatogenesis. A morphologic and flow cytometric study. Analytical and Quantitative Cytology and Histology18, 361–373.
99.
ShettyG., KrishnamurthyH., KrishnamurthyH.N., BhatnagarA.S., & MoudgalN.R. (1998). Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. radiata). Steroids63, 414–420.
100.
SonH.Y., KimY.B., KangB.H., ChoS.W., HaC.S., & RohJ.K. (1999). Effects of 2-bromopropane on spermatogenesis in the Sprague-Dawley rat. Reproductive Toxicology13, 179–187.
101.
SpanoM., PacchierottiF., UccelliR., AmendolaR., & BartoleschiC. (1989). Cytotoxic effects of benzene on mouse germ cells determined by flow cytometry. Journal of Toxicology and Environmental Health26, 361–372.
102.
SpanoM., AmendolaR., BartoleschiC., EmilianiS., CordelliE., PetitJ.M., JulienR., & RatinaudM.H. (1991). Evaluation of 2-methoxyacetic acid toxicity on mouse germ cells by flow cytometry. Journal of Toxicology and Environmental Health34, 157–176.
103.
SpanoM., BartoleschiC., CordelliE., LeterG., SegreL., MantovaniA., FazziP., & PacchierottiF. (1996). Flow cytometric and histological assessment of 1,2,3,4-diepoxybutane toxicity on mouse spermatogenesis. Journal of Toxicology and Environmental Health47, 423–441.
104.
SpanoM., BartoleschiC., CordelliE., LeterG., TiveronC., & PacchierottiF. (1996). Flow cytometric assessment of trophosphamide toxicity on mouse spermatogenesis. Cytometry24, 174–180.
105.
SuterL., BobadillaM., KochE., & BechterR. (1997). Flow cytometric evaluation of the effects of doxorubicin on rat spermatogenesis. Reproductive Toxicology11, 521–531.
106.
SuterL., ClemannN., KochE., BobadillaM., & BechterR. (1998). New and traditional approaches for the assessment of testicular toxicity. Reproductive Toxicology12, 39–47.
107.
ToppariJ., BishopP.C., ParkerJ.W., AhmadN., GirgisW., & diZeregaG.S. (1990). Cytotoxic effects of cyclophosphamide in the mouse seminiferous epithelium: DNA flow cytometric and morphometric analysis. Fundamental and Applied Toxicology15, 44–52.
108.
TrainaM.E., ResciaM., UrbaniE., MantovaniA., MacriC., RicciardiC., StaziA.V., FazziP., CordelliE., EleuteriP., LeterG., & SpanoM. (2003). Long-lasting effects of lindane on mouse spermatogenesis induced by in utero exposure. Reproductive Toxicology17, 25–35.
109.
van KronnenburgM.J., BeckJ.L., VemerH.M., ThomasC.M., RollandR., & HermanC.J. (1986). Effects of danazol on spermatogenesis in adult rats. Journal of Reproduction and Fertility77, 233–238.
110.
WeissenbergR., GolanR., ShochatL., & LewinL.M. (2002). Procarbazine effects on spermatogenesis in golden hamster: a flow cytometric evaluation. Archives of Andrology48, 91–100.
111.
WigerR., HongsloJ.K., EvensonD.P., De AngelisP., SchwarzeP.E., & HolmeJ.A. (1995). Effects of acetaminophen and hydroxyurea on spermatogenesis and sperm chromatin structure in laboratory mice. Reproductive Toxicology9, 21–33.
112.
YoonC.Y., HongC.M., ChoY.Y., ChungY.H., MinH.K., YunY.W., LeeB.J., YangK.H., LeeY.S., & KimC.K. (2003). Flow cytometric assessment of ethylene glycol monoethyl ether on spermatogenesis in rats. Journal of Veterinary Medical Science65, 207–212.
113.
JohnsonK.J., HalE.S., & BoekelheideK. (1991). 2,5-Hexanedione exposure alters the rat Sertoli cell cytoskeleton. I. Microtubules and seminiferous tubule fluid secretion. Toxicology and Applied Pharmacology111, 432–442.
114.
FioriniC., Tilloy-EllulA., ChevalierS., CharuelC., & PointisG. (2004). Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants. Reproductive Toxicology18, 413–421.
115.
FordW.C., & WaitesG.M. (1981). The effect of high doses of 6-chloro-6-deoxyglucose on the rat. Contraception24, 577–588.
116.
JonesA.R., & CooperT.G. (1999). A re-appraisal of the post-testicular action and toxicity of chlorinated antifertility compounds. International Journal of Andrology22, 130–138.
117.
TsunodaY., & ChangM.C. (1976). Fertilizing ability in vivo and in vitro of spermatozoa of rats and mice treated with alpha-chlorohydrin. Journal of Reproduction and Fertility46, 401–406.
118.
CullenC., SinghA., DykemanA., RiceD., & FosterW. (1993). Chronic lead exposure induces ultrastructural alterations in the monkey seminal vesicle. Journal of Submicroscopic Cytology and Pathology25, 127–135.
119.
StoccoD.M. (2001). StAR protein and the regulation of steroid hormone biosynthesis. Annual review of physiology63, 193–213.
120.
CookeB.A., JanszenF.H., ClotscherW.F., & van der MolenH.J. (1975). Effect of protein-synthesis inhibitors on testosterone production in rat testis interstitial tissue and Leydig-cell preparations. Biochemical Journal150, 413–418.
121.
SchurmeyerT., & NieschlagE. (1984). Effect of ketoconazole and other imidazole fungicides on testosterone biosynthesis. Acta Endocrinologica105, 275–280.
122.
KanP.B., HirstM.A., & FeldmanD. (1985). Inhibition of steroidogenic cytochrome P-450 enzymes in rat testis by ketoconazole and related imidazole anti-fungal. Journal of Steroid Biochemistry23, 1023–1029.
123.
WalshL.P., WebsterD.R., & StoccoD.M. (2000). Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene. Journal of Endocrinology167, 253–263.
124.
JohanssonM.K., SandersonJ.T., & LundB. (2002). Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. Toxicology in Vitro16, 113–121.
125.
YueW., & BrodieA.M. (1997). Mechanisms of the actions of aromatase inhibitors 4-hydroxyan-drostenedione, fadrozole, and aminoglutethimide on aromatase in JEG-3 cell culture. Journal of Steroid Biochemistry and Molecular Biology63, 317–328.
126.
Kumi-DiakaJ., & ButlerA. (2000). Caspase-3 protease activation during the process of genistein-induced apoptosis in TM4 testicular cells. Biology of the Cell92, 115–124.
127.
BrinsterR.L., & ZimmermannJ.W. (1994). Spermatogenesis following male germ-cell transplantation. Proceedings of the National Academy of Sciences of the USA91, 11298–11302.
128.
GrayL.E., OstbyJ., MonossonE., & KelceW.R. (1999). Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat. Toxicology and Industrial Health15, 48–64.
129.
OhnoS., MatsumotoN., WatanabeM., & NakajinS. (2004). Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II. Journal of Steroid Biochemistry and Molecular Biology88, 175–182.
130.
EnglerH., TaurogA., & DorrisM.L. (1982). Preferential inhibition of thyroxine and 3,5,3’-triiodothyronine formation by propylthiouracil and methylmercaptoimidazole in thyroid peroxidase-catalyzed iodination of thyroglobulin. Endocrinology110, 190–197.
131.
AtterwillC.K., CollinsP., BrownC.G., & HarlandR.F. (1987). The perchlorate discharge test for examining thyroid function in rats. Journal of Pharmacological Methods18, 199–203.
132.
KaplanM.M., & BreitbartR. (1984). Conversion of thyroxine to triiodothyronine in the anterior pituitary gland and the influence of this process on thyroid status. Hormone and Metabolic Research14, 79–85.
133.
LawsS.C., CareyS.A., FerrellJ.M., BodmanG.J., & CooperR.L. (2000). Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicological Sciences54, 1544–1567.
134.
HosokawaS., MurakamiM., IneyamaM., YamadaT., YoshitakeA., YamadaH., & MiyamotoJ. (1993). The affinity of procymidone to androgen receptor in rats and mice. Journal of Toxicological Sciences18, 83–93.
135.
OstbyJ., KelceW.R., LambrightC., WolfC.J., MannP., & GrayL.E. (1999). The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro.Toxicology and Industrial Health15, 80–93.
136.
VinggaardA.M., JoergensenE.C., & LarsenJ.C. (1999). Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals. Toxicology and Applied Pharmacology155, 150–160.
137.
BrodieA.H., WuJ.T., MarshD.A., & BrodieH.J. (1979). Antifertility effects of an aromatase inhibitor, 1,4,6-Androstratriene 3,17-Dione. Endocrinology104, 118–121.
138.
VinggaardA.M., HnidaC., BreinholtV., & LarsenJ.C. (2000). Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro.Toxicology in Vitro14, 227–234.
139.
DavisB.J., AlmekinderJ.L., FlaglerN., TravlosG., WilsonR., & MaronpotR.R. (1997). Ovarian luteal cell toxicity of ethylene glycol monomethyl ether and methoxy acetic acid in vivo and in vitro.Toxicology and Applied Pharmacology142, 328–37.
140.
JayesF.L., & DavisB.J. (2004). Granulosa cell function is impaired by environmentally relevant levels of mono-(2-Ethylhexyl) phthalate (MEHP). Biology of Reproduction (Special Issue), 166–166.
141.
NagaT., YoshimuraS., TotsukaY., & WakabayashiK. (2002). Maternal and developmental toxicity in mice by aminophenylnorharman, formed from norharman and aniline. Human and Experimental Toxicology21, 147–51.
142.
CummingsA.M., RhodesB.E., & CooperR.L. (2000). Effect of atrazine on implantation and early pregnancy in 4 strains of rats. Toxicological Sciences58, 135–43.