It is an honour to have been asked to follow in the footsteps of Professor Russell (1) and deliver the FRAME Annual Lecture. In doing so, I am not speaking in any official capacity. I am speaking as myself: someone who has had a 30-year association with medicine and the biological sciences, who has had more time and reason than most to reflect upon the changes that have taken place during that period, and to think about how things may develop in the future. The views expressed tonight are based upon, and represent, my personal experience, expectations and aspirations.
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