The Prohibition of Routine Ascites Production of Monoclonal Antibodies in the United States: A Successful Application of the Alternatives Approach to Biomedical Research
Restricted accessOtherFirst published online September, 2000
The Prohibition of Routine Ascites Production of Monoclonal Antibodies in the United States: A Successful Application of the Alternatives Approach to Biomedical Research
KöhlerG., & MilsteinC. (1975). Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, London256, 495–497.
2.
McArdleJ. (1997/1998). Alternatives to ascites production of monoclonal antibodies. AWIC Newsletter 834, 1–4.
3.
HendriksenC.F.M. (1998). A call for a European prohibition of monoclonal antibody (mAb) production by the ascites procedure in laboratory animals. ATLA26, 523–540.
4.
MarxU., EmbletonM.J., FischerR., GruberF. P., HanssonU., HeuerJ., de LeeuwW.A., LogtenbergT., MerzW., PortetelleD., RometteJ-L., & StraughanD.W. (1997). Monoclonal antibody production. The report and recommendations of ECVAM Workshop 23. ATLA25, 121–137.
5.
StangB.V., WoodP.A., ReddingtonJ.J., ReddingtonG.M., & HeidelJ.R. (1998). Monoclonal antibody production in gas-permeable flexible flasks, using serum-free media. Continued Topics in Laboratory Animal Science37, 55–60.
6.
LipskiL.A., WitzlebM.P., ReddingtonG.M., & ReddingtonJ.J. (1998). Evaluation of small to moderate scale in vitro monoclonal antibody production via the use of the i-MAb gas permeable bag system. Research in Immunology149, 547–552.
7.
EEC (1986). Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. Official Journal of the European CommunitiesL358, 1–29.
8.
CAAT. (1997). Johns Hopkins Center for Alternatives to Animal Testing. Technical Report 8, Alternatives in Monoclonal Antibody Production.41 pp. Baltimore, MD, USA: CAAT
9.
HalderM., EmbletonM.J., FischerR., de GeusB., HendriksenC., de LeeuwW.A., MarxU., & BallsM. (1998). Comments on Appendix C of the National Institutes of Health response to the petition of the American Anti-Vivisection Society to prohibit the use of animals in the production of monoclonal antibodies. ATLA26, 549–554.
10.
National Research Council. (1999). Monoclonal Antibody Production, 59 pp. Washington DC, USA: National Academy Press.