This paper presents evidence that restraint of growth and development during critical periods of fetal life and infancy have an important effect on the development of cardiovascular disease.
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References
1.
DubosR.SavageD.SchaedlerR. (1966). Biological Freudianism: lasting effects of early environmental influences. Pediatrics, 38, 789–800.
2.
BlackwellN.M.BlackwellR. Q.YuT.T.S.WengY.S.ChowB.F. (1968). Further studies on growth and feed utilization in progeny of underfed mother rats. J. Nutr., 97, 79–84.
3.
WinickM.NobleA. (1966). Cellular response in rats during malnutrition at various ages. J. Nutr., 89, 300–6.
4.
BarkerD.J.P.OsmondC. (1986). Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet, 1, 1077–81.
5.
BarkerD.J.P.OsmondC.LawC. (1989). The intra-uterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J. Epidemiol Community Health, 43, 237–40.
6.
Local Government Board. Thirty-ninth annual report 1909–10. Supplement on infant and child mortality. London, HMSO, 1910.
7.
CampbellJ.M.CameronD.JonesD.M. (1932). Ministry of Health Reports on Public Health and Medical Subjects, No. 68. High maternal mortality in certain areas. London, HMSO.
8.
OsmondC.BarkerD.J.P.SlatteryJ.M. (1990). Risk of death from cardiovascular disease and chronic bronchitis determined by place of birth in England and Wales. J. Epidemiol Community Health, 44, 139–141.
9.
BarkerD.J.P.WinterP.D.OsmondC.MargettsB.SimmondsS.J. (1989). Weight in infancy and death from ischaemic heart disease. Lancet, ii, 577–580.
10.
MeadeT.W.BarkerD.J.P.FallC.OsmondC.Fetal and infant growth in relation to haemostatic factors in adult life. Br. Med. J.in press.
11.
HalesC.N.BarkerD.J.P.ClarkP.M.S.CoxL.J.FallC.OsmondC.WinterP.D. (1991). Fetal and infant growth and impaired glucose tolerance at age 64 years. Br. Med. J., 303, 1019–22.
12.
BarkerD.J.P.BullA.R.OsmondC.SimmondsS.J. (1990). Fetal and placental size and risk of hypertension in adult life. Br. Med. J., 301, 259–62.
13.
BarkerD.J.P. (1991). The intrauterine environment and adult cardiovascular disease. In: Ciba symposium 156. The childhood environment and adult disease. Chichester, John Wiley.
MeadeT.W.MellowsS.BrozovicM.MillerG.J.ChakrabatiR.R.NorthW.R.S.HainesA.P.StirlingYImesonJ.D.ThompsonS.G. (1986). Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet, 2, 533–37.
16.
BarkerD.J.P.OsmondC.GoldingJ.KuhD.WadsworthM.E.J. (1989). Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. Br. Med. J., 298, 564–567.
17.
GodfreyK.M.RedmanC.W.G.BarkerD.J.P.OsmondC. (1991). The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight. Br. J. Obstet. Gynaecol., 98, 886–891.
18.
Carr-HillR.CampbellD.M.HallM.H.MeredithA. (1987). Is birthweight determined genetically?Br. Med. J., 295, 687–689.
