The nutritional contribution of human colonic function has been poorly appreciated. As well as absorbing the equivalent of a daily oral intake of sodium and water, other minerals can be absorbed. Up to 10% of energy requirements may come from carbohydrate entering the colon, fermentation to short chain fatty acids that are absorbed being intermediate steps. The role of the large intestine in nitrogen and fat metabolism is unknown, as is its contribution to vitamin supplies.
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References
1.
WrongO. M.EdmondsC. J.ChadwickV. S.(1981). The large intestine: Its role in mammalian nutrition and homeostatis. MTP Press, Lancaster.
2.
CummingsJ. H.(1975). The colon: absorptive, secretory and metabolic functions. Digestion, 13, 232–240.
3.
TurnbergL. A.(1970). Electrolyte absorption from the colon. Gut, 11, 1049–1054.
4.
LevitanR.FordtranJ. S.BurrowsB. A.(1962). Water and salt absorption in the human colon. J. Clin. Invest., 41, 1754–1759.
5.
GradyG. F.DuhamelR. C.MooreE. W.(1970). Active transport of sodium by human colon in vitro. Gastroenterology, 59, 583–588.
6.
ArchampongE. Q.HarrisJ.ClarkC. G.(1972). The absorption and secretion of water and electrolytes across the healthy and diseased colonic mucosa measured in vitro. Gut, 13, 880–886.
7.
EdmondsC. J.(1971). Absorption of sodium and water by human rectum measured by a dialysis method. Gut, 12, 356–362.
8.
HawkerP. C.MashiterK. E.TurnbergL. A.(1978). Mechanisms of transport of Na, Cl, and K in the human colon. Gastroenterology, 74, 1241–1247.
9.
DevroedeG. J.PhillipsS. F.(1969). conservation of sodium, chloride and water by the human colon. Gastroenterology, 56, 101–109.
10.
Salas-CollC. A.KermodeJ. C.EdmondsC. J.(1976). Potassium transport across the distal colon in man. Clinical Science, 51, 287–296.
11.
PhillipsS. F.GillerJ.(1973). The contribution of the colon to electrolyte and water conservation in man. J. Lab. Clin. Med.81, 733–746.
12.
EmontsP.VidonN.BernierJ.-J.RambaudJ.-C.(1979). Etude sur 24 heures des flux liquidiennes intestinaux chez l'homme normal par la technique de la perfusion lente d'un marqueur non absorbable. Gastroenterol. Clin. Biol.3, 139–146.
13.
PetithM. M.SchedlM. P. (1976). Intestinal adaptation of dietary calcium restriction. In vivo cecal and colonic calcium transport in the rat. Gastroenterology, 71, 1039–1042.
14.
FawcettD. W.GensJ. P. (1943). Magnesium poisoning following an enema of Epsom salt solution. J.A.M.A.123, 1028–1029.
15.
MillerT. L.WolinM. J.(1979). Fermentation by saccharolytic intestinal bacteria. Am. J. Clin. Nutr.32, 164–172.
16.
ParkerD. S.(1976). The measurement of the production rates of volatile fatty acids in the caecum of the conscious rabbit. Br. J. Nutr.36, 61–70.
17.
GlinskyM. J.SmithR. M.SpiresH. R.DavisC. L.(1976). Measurement of volatile fatty acid production rates in the cecum of the pony. J. Anim. Sci.42, 1465–1470.
18.
CastroG. A.(1977). Digestion and absorption of specific nutrients. In (JohnsonJ. R., editor) Gastrointestinal Physiology. C. V. Mosby & Co., St. Louis, 122–138.
19.
McNeilN. I.BinghamS.ColeT. J.GrantA. M.CummingsJ. H.(1982). Diet and health of people with an ileostomy. 2. Ileostomy function and nutritional state. Br. J. Nutr.47, 407–415.
20.
StephenA. M.HaddadA. C.PhillipsS. F.(1981). Dietary and endogenous sources of carbohydrate substrate in the human colon. Gut, 22, A893.
21.
SouthgateD. A. T.DurninJ. V. G. A.(1970). Calorie conversion factors. An experimental measurement of the factors used in the calculation of the energy values of human diets. Br. J. Nutr.24, 517–535.
22.
McNeilN. I.CummingsJ. H.JamesW. P. T.(1978). Short chain fatty acid absorption by the human large intestine. Gut, 19, 819–822.
23.
RuppinH.Bar-MeirS.SoergelK. H.WoodC.SchmittM. G.(1980). Absorption of short-chain fatty acids by the colon. Gastroenterology, 78, 1500–1507.
24.
McNeilN. I.(1980). Short chain fatty acid absorption in the human large intestine. Thesis, University of Cambridge.
25.
ArgenzioR. A.SouthworthM.(1975). Sites of organic acid production and absorption in gastrointestinal tract of pig. Am. J. Physiol.228, 454–460.
26.
ArgenzioR. A.SouthworthM.LoweJ. E.StevensC. E. (1977). Interrelationship of Na, HCO3, and volatile fatty acid transport by equine large intestine. Am. J. Physiol.233, E469-478.
27.
WolinM. J.(1981). Fermentation in the rumen and human large intestine. Science, 213, 1463–1468.
28.
CummingsJ. H.(1981). Short chain fatty acids in the human colon. Gut, 22, 763–779.
29.
CummingsJ. H.HillM. J.JenkinsD. J. A.PearsonJ. R.WigginsH. S.(1976). Changes in fecal composition and colonic function due to cereal fiber. Am. J. Clin. Nutr.32, 1094–2101.
30.
RichardsP.Metcalfe-GibsonA.WardE. E.WrongO. M.HoughtonB. J. (1967). Utilization of ammonia nitrogen for protein synthesis in man, and the effect of protein restriction and uraemia. Lancet, ii, 845–849.
31.
WrongO. M.VinceA. J.WaterlowJ. C.(1982). The origins and bacterial metabolism of faecal ammonia. In Colon and Nutrition (KasperH.GoebellH., eds.). MTP Press, Lancaster, 133–137.
32.
LinscheerW. G.CaselliW. P.MooreE. W.PattersonJ. F.ChalmersT. C.(1964). Absorption and plasma concentrations of octanoic acid in cirrhosis. J. Clin. Invest.43, 1280.
33.
MaxJ.-P.RollinP.DrouinP.DebryP.(1982) Absorption rectale de triacylglycérols a chaines moyenne chez l'homme. Gastroenterol. Clin. Biol.6, 581–584.
34.
BinderH. J.Van NoordenS.(1969). The distribution of lipid in colonic mucosa. Proc. Soc. Exp. Biol. Med.131, 1119–1123.
