A 63-year-old Chinese man complained of a throbbing headache and dizziness for one month. A solitary pulmonary tumor with a single brain metastasis was found. Craniotomy and right upper lobectomy of the lung were performed separately to remove the tumors totally. Pathological studies confirmed the diagnosis of pulmonary adenosquamous carcinoma with brain metastasis. Interestingly, many eggs of Paragonimus westermani were found over the cancerous part of the lung. The association of pulmonary adenosquamous carcinoma with previous paragonimiasis has not been reported previously. The relationship between parasite infestation and subsequent oncogenesis deserves further investigation.
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References
1.
MansonP. Further observation on microfilariae with description of a new species. J Quekett Micro Club1880;6:133–140.
2.
GoldsmithRHeynemanD. Lung fluke disease. In: Tropical Medicine and Parasitology, Appleton & Lange, 1989;472–83.
3.
YokgawaM. Paragonimus and paragonimiasis. Adv Parasitol1965;3:99–158.
4.
SunT. Paragonimiasis. In: Pathology and clinical features of parasite disease. New York: Masson, 1982;253–60.
5.
ImJGWhangHYKimWSPleuropulmonary paragonimiasis: radiological findings in 71 patients. AJR1992;159:39–43.
6.
SingcharoenTSilprasertW. CT finding in pulmonary paragonimiasis. J. Comp Assist Tomography1987;11:1101–3.
7.
FukudaKFujinoTOgumaTStudies on host specificity in Paragonimus westermani: ultrastructural study of inflammatory reactions to the parasite in rat muscle. Int J Parasitol1993;23:757–63.
8.
World Health Organization. The World Health Organization histological typing of lung tumors, second ed. Am J Clin Pathol1982;77:123–36.
9.
FittzgibbonPLKernWH. Adenosquamous carcinoma of the lung: a clinical and pathological study of seven cases. Hum Pathol1985;16:463–6.
10.
NaunheimKSTaylorJRSkoseyCAdenosquamous lung carcinoma: clinical characteristics, treatment and prognosis. Ann Thorac Surg1987;44:462–6.
11.
TakamoriSNoguchiMMorinagaSClinical characteristics of adenosquamous carcinoma of the lung. Cancer1991;67:649–54.
