The present work was conducted to study the status of oxidative stress (oxy-free radicals) in 24 patients with acute myocardial infarction and 12 matched healthy control patients and furthermore evaluate the effect of oral vitamin E on altered oxyfree radicals in these patients. The parameters assessed for oxy-free radical status were superoxide anion and malonyldialdehyde. These were found to be increased during acute myocardial infarction and this increment had a normalizing trend with the passage of time. It was found that the administration of vitamin E accelerated the normalizing trend of both superoxide anion and malonyldialdehyde. Thus, vitamin E has an antioxidant effect in acute myocardial infarction.
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