From April 1990 to December 1992, we used aprotinin in 80 pediatric cases undergoing cardiac surgery. Most patients had moderate to severe tetralogy of Fallot and other complex cyanotic diseases, and 12 cases were reoperated. One-half to one-third of the recommended dose was adopted, and 3 different patterns of administration were compared. All procedures achieved good results with less postoperative bleeding. We suggest the simplest procedure—adding 1 bolus dose of aprotinin to the pump prime—as the method of choice.
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