Early and midterm outcomes of Frozenix Partial-ET versus conventional Frozenix in total arch replacement for acute type A aortic dissection

Abstract

Background

In this study, we sought to evaluate the early outcomes and aortic remodeling effects of the Frozenix Partial-ET in total arch replacement for acute type A aortic dissection, and its potential to reduce distal stent graft-induced new entry (dSINE).

Methods

We retrospectively analyzed 47 patients who underwent total arch replacement with a frozen elephant trunk (FET) between January 2017 and December 2024, among whom, 34 received the conventional Frozenix (Full-FET group), and 13 received the Frozenix Partial-ET (Partial-ET group). Clinical outcomes, CT-based morphological parameters, and aortic remodeling were compared.

Results

There were no significant differences between the two groups regarding mortality or major complications. Patients in the Partial-ET group had greater distal stent angulation (34.5 ± 8.9° vs. 24.5 ± 13.7°), and no dSINE was observed during a mean follow-up period of 6.4 months. Aortic remodeling outcomes were comparable between the two groups, while the Partial-ET group demonstrated shorter lower body ischemia time and more proximal distal stent deployment.

Conclusions

Application of Frozenix Partial-ET resulted in outcomes comparable to those obtained using the conventional device, without an increase in mortality or major complications. Despite a greater distal angulation, no early dSINE was observed during the study period. This device may represent a feasible option in selected cases of acute type A dissection, although further long-term data are needed to clarify its efficacy.