Myxofibrosarcomas are rare cardiac neoplasms that usually involve the left atrium and present as unicentric or multicentric tumor masses. They can arise from both myocardial and valvular tissue, and can be locally aggressive or show distant metastasis. We describe an unusual case of myxofibrosarcoma involving both the right atrium and ventricle in a 30-year-old man, which was surgically resected. After 12 months of follow-up, there was no recurrence or metastasis.
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