Abstract
Teratoma is the second most common mediastinal neoplasm, but malignant transformation in mature teratomas is uncommon at both gonadal and extragonadal sites. A 35-year-old woman presented with an anterior mediastinal mass. Computed tomography suggested a teratoma. Meticulous pathological examination helped in detecting a neuroendocrine neoplasm (carcinoid) within the mature teratoma. Malignant transformation in a teratoma is difficult to diagnose on clinical and radiological assessment; histopathology is essential to detect the malignant nature of these neoplasms.
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References
1.
Yetkin
U
Orgencalli
A
Yuncu
G
Gurbuz
A
. Large mediastinal teratoma originating from the aortic adventitia . Tex Heart Inst J
2004 ; 31 : 309 –12 .
2.
Lancaster
KJ
Liang
CY
Myers
JC
McCabe
KM
. Goblet cell carcinoid arising in a mature teratoma of the mediastinum . Am J Surg Pathol
1997 ; 21 : 109 –13 .
3.
Manivel
C
Wick
MR
Abenoza
P
Rosai
J
. The occurrence of sarcomatous components in primary mediastinal germ cell tumors . Am J Surg Pathol
1986 ; 10 : 711 –7 .
4.
Rudnicka
L
Papla
B
Malinowski
E
. Mature cystic teratoma of the mediastinum containing a carcinoid. A case report . Pol J Pathol
1998 ; 49 : 309 –12 .
5.
Hsu
JS
Kang
WY
Chou
SH
Chuang
MT
. Mature cystic teratoma in the anterior mediastinum containing a carcinoid . J Thorac Imaging
2006 ; 21 : 60 –2 .
6.
Squeff
FA
Gerace
ES
Saad Júnior
R
Botter
M
Gonçalves
R
Paes
JF
. Mediastinal teratoma with malignant degeneration . J Bras Pneumol
2008 ; 34 : 631 –4 .
7.
Schnirer
II
Yao
JC
Ajani
JA
. Carcinoid—a comprehensive review . Acta Oncol
2003 ; 42 : 672 –92 .
8.
Ulbright
TM
Loehrer
PJ
Roth
LM
Einhorn
LH
Williams
SD
Clark
SA
. The development of non-germ cell malignancies within germ cell tumors . Cancer
1984 ; 54 : 1824 –33 .