Amiodarone is one of the commonly used anti-arrhythmic agents with well-recognized chronic pulmonary toxicity. We present our experience of a patient with a fatal outcome after coronary artery bypass grafting and a short course of amiodarone treatment with a low total cumulative dose for the treatment of postoperative atrial fibrillation. Necropsy revealed diffuse pulmonary damage due to acute amiodarone lung toxicity.
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References
1.
RotmenschHHLironMTupilskyMLaniadoS. Possible association of pneumonitis with amiodarone therapy. Am Heart J1980; 100: 412–3.
2.
KaushikSHussainAClarkePLazarHL. Acute pulmonary toxicity after low-dose amiodarone therapy. Ann Thorac Surg2001; 72: 1760–1.
DaoudEGStrickbergerSAManKCGoyalRDeebGMBollingSFPaganiFDBitarCMeissnerMDMoradyF. Preoperative amiodarone as prophylaxis against atrial fibrillation after heart surgery. N Engl J Med.1997 Dec 18; 337 (25): 1785–91.
5.
GuarnieriTNolanSGottliebSODudekALowryDR. Intravenous amiodarone for the prevention of atrial fibrillation after open heart surgery: the Amiodarone Reduction in Coronary Heart (ARCH) trial. J Am Coll Cardiol1999; 34: 343–7.
6.
AshrafianHDaveyP. Is amiodarone an underrecognized cause of acute respiratory failure in the ICU?Chest2001; 120: 275–82.
7.
DeanPJGroshartKDPorterfieldJGIansmithDHGoldenEBJrAmiodarone-associated pulmonary toxicity. A clinical and pathologic study of eleven cases. Am J Clin Pathol1987; 87: 7–13.
8.
LardinoisDHandschinAWederW. Acute amiodarone-induced pulmonary toxicity after lung operation. Ann Thorac Surg2002; 73: 2033–4.