We describe a 58-year-old man who was successfully treated with a β-adrenergic receptor blocking agent for intractable hemolysis due to paraprosthetic leakage. After replacement of a mitral prosthetic valve with another mechanical valve, the patient suffered intractable intravascular hemolysis resulting from recurrent paraprosthetic leakage. With oral administration of a β-adrenergic receptor blocker, betaxolol hydrochloride, for 3 months, the hemoglobin value increased from 9.7 g·dL−1 to 12.4 g·dL−1, although glutamic oxaloacetic transaminase and lactic dehydrogenase values remained elevated.
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