Transfusion related acute lung injury (TRALI) is an uncommon complication following administration of blood products. It is often difficult to differentiate from other commoner causes of cardio-respiratory instability. However, prompt diagnosis and management is associated with favorable outcome.
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References
1.
SazamaK. Reports of 355 transfusion-associated deaths: 1976 through 1985. Transfusion1990;30:583–90.
2.
PopovskyMAAbelMDMooreSB. Transfusion-related acute lung injury associated with passive transfer of antileukocyte antibodies. Am Rev Respir Dis1983;128:185–9.
3.
KopkoPMMarshallCSMacKenzieMRHollandPVPopovskyMA. Transfusion-related acute lung injury: Report of a clinical look-back investigation. JAMA2002;287:1968–71.
4.
SillimanCCBoshkovLKMehdizadehkashiZElziDJDickeyWOPodloskyL. Transfusion-related acute lung injury: Epidemiology and a prospective analysis of etiologic factors. Blood2003:101:454–62.
5.
LooneyMRGropperMAMatthayMA. Transfusion-related acute lung injury: A review. Chest2004;126:249–58.
6.
WymanTHBjornsenAJElziDJSmithCWEnglandKMKelherM. A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: Requirements for adherence and chemokine release. Am J Physiol Cell Physiol2002;283: C1592–603.
7.
KopkoPMPaglieroniTGPopovskyMAMutoKNMacKenzieMRHollandPV. TRALI: Correlation of antigen-antibody and monocyte activation in donor-recipient pairs. Transfusion2003;43:177–84.
8.
PopovskyMAMooreSB. Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion1985;25:573–7.