Clostridia are the main cause of nontraumatic spontaneous gas gangrene. Poor blood flow due to arterial occlusion exacerbates the anaerobic condition. Fulminant gas gangrene in a 54-year-old man with atherosclerosis obliterans was treated by revascularization of the iliac artery using endarterectomy, and his gangrenous lower leg was amputated. However, he died from renal failure.
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References
1.
KahnOWagnerWBessmanAN. Mortality of diabetic patients treated surgically for lower limb infection and or gangrene. Diabetes1974;23: 287–92.
2.
RechnerPMAggerWAMruzKCogbillTH. Clinical features of clostridial bacteremia: a review from a rural area. Clin Infect Dis2001;33: 349–53.
3.
MartyATFillerRM. Recovery from non-traumatic localised gas gangrene and clostridial septicaemia. Lancet1969;2(7611):79–81.
4.
BartlettJGSutterVLFinegoldSM. Treatment of anaerobic infections with lincomycin and clindamycin. N Engl J Med1972;287: 1006–10.
5.
BryantAEChenRYNagataYWangYLeeCHFinegoldSClostridial gas gangrene. II. Phospholipase C-induced activation of platelet GPIIb-IIIa mediates vascular occlusion and myonecrosis in Clostridium perfringens gas gangrene. J Infect Dis2000;182: 808–15.
6.
SlotkiINMacIverJEMallickNPPalmerHM. Acute intravascular hemolysis with minimal renal impairment in Clostridium perfringens infection. Clin Nephrol1976;6: 451–2.
7.
CampistolJMAbadCNogueSBertranA. Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation. J Cardiovasc Surg (Torino)1988;29: 410–2.
8.
KorhonenKKlossnerJHirnMNiinikoskiJ. Management of clostridial gas gangrene and the role of hyperbaric oxygen. Ann Chir Gynaecol1999;88: 139–42.
