Extranodal Head and Neck Sinus Histiocytosis with Massive Lymphadenopathy

Abstract

Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare, benign, and frequently chronic disorder that was first described in 1969. It is characterized by painless cervical lymphadenopathy, low-grade fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia.¹'² In 22% of patients, extranodal infiltration occurs in head and neck sites.³ The purpose of this article is to present a case of SHML that had extranodal disease in the sinonasal cavities, pharynx, and subglottis.