Abstract
The effects of human leukocyte interferon (HulFN-α) and fibroblast Interferon (HulFN-β) on cell growth and induction of antigens related to Epstein-Barr virus (EBV) in a nasopharyngeal carcinoma hybrid cell line (NPC-KT) were studied. HulFN-α showed little antiproliferative and anti-EBV effect on NPC-KT cells. On the other hand, HulFN-β showed modest antiproliferative effect on NPC-KT cells, the effect was dependent on time and HulFN-β concentration. HulFN-β alone was ineffective in inhibiting EBV-related antigens, but NPC-KT cells treated for more than 1 week with HulFN-β inhibited the action of the chemical inducer of EBV, n-butyric acid, and the appearance of EBV-induced early antigen and EB viral capsid antigen was inhibited more than 50% compared with NPC-KT cells treated with n-butyric acid alone.
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