The sensory element of the acoustic startle reflex was studied in neonatal rats. Stimulus frequency, background noise, and stimulus presentation rate all affected the reflex. The performance of jaundiced rats with central auditory pathology is initially poorer than that of nonjaundiced rats but rapidly improves to the level of the controls, suggesting that the jaundiced rats may be a model for central auditory disturbances in humans. Startle reflex measurements give no indication that jaundiced rats surviving the testing period had neural hearing loss.
JohnsonLSarmientoFBlancWADayR: Kernicterus in rats with an inherited deficiency of glycuronyl transferase. AMA J Dis Child97:591–608, 1959.
3.
GunnCK: Hereditary acholuric jaundice in a new mutant strain of rats. J Hered29:137–139, 1938.
4.
LenhardtML: Effects of hyperbilirubinemia on the hearing and vocal development in Gunn rats. Arch Otolaryngol108:339–342, 1982.
5.
BelalAJr: Effects of hyperbilirubinemia on the inner ear in Gunn rats. J Laryngol Otol89:259–265, 1975.
6.
JewJSandquistD: CNS changes in hyperbilirubinemia. Arch Neurol36:149–154, 1979.
7.
DublinWB: Neurologic lesions of erythroblastosis in relation to nuclear deafness. Am J Clin Pathol21:935–939, 1951.
8.
LeviGSohmerHKapitulmikJ: Auditory nerve and brain stem responses in homozygous jaundiced Gunn rats. Arch Otorhinolaryngol232:139–142, 1981.
9.
ChisinRPerlmanMSohmerH: Cochlear and brain stem responses in hearing loss following neonatal hyperbilirubinemia. Ann Otol Rhinol Laryngol89:352–357, 1979.
10.
HensonC: New breed of jaundiced rat. National Institutes of Health, Bethesda, Md, 1982, Veterinary Resources Branch.
