Simultaneous concentrations of total plasma platinum, filterable platinum, intact cisplatin, and total tumor platinum were measured for 24 hours after an intravenous bolus of cisplatin in five patients. Tumor concentrations of drug were greater than could be explained on the basis of circulating plasma platinum at the time of biopsy. Intratumor platinum concentrations derived from this study provide guidance for selection of the appropriate drug concentrations for in vitro chemosen-sitivity testing of head and neck cancer in humans.
Get full access to this article
View all access options for this article.
References
1.
. MuggiaFMRozencweigMLouieAE: Role of chemotherapy in head and neck cancer: Systemic use of single agents and combination in advanced disease. Head Neck Surg2: 196–205, 1980.
2.
. WittesRECvitkovicEShahJGeroldFPStrongEW: Cis-dichlorodiammineplatinum (II) in the treatment of epidermoid carcinoma of the head and neck. Cancer Treat Rep61: 359–366, 1977.
3.
. PriesnerDSternsonLAReptaAJ: Analysis of total platinum in tissue samples by flameless atomic absorption spectrophotometry elimination of the need for sample digestion. Anal Lett14: 1255–1268, 1981.
4.
. BannisterSJChangYSternsonLAReptaAJ: Atomic absorptions spectrophotometry of free circulating platinum species in plasma derived from cis-dichlorodiammineplatinum (II). Clin Chem24: 877–880, 1978.
5.
. RileyCMSternsonLAReptaAJ: High performance liquid chromatography of inorganic platinum (II) complexes using solvent-generated anion exchanges. II. The effect of electrolytes on solute retention. J Chromatogr219: 235–244, 1981.
6.
. HamburgerAWSalmonSE: Primary bioassay of human tumor stem cells. Science197: 461–463, 1977.
7.
. MattoxDEVon HoffDD: In vitro stem cell assay in head and neck squamous carcinoma. Am J Surg140: 527–530, 1980.
8.
. BannisterSJSternsonLAReptaAJJamesGW: Measurement of free-circulating cis-dichlorodiammineplatinum (II) in plasma. Clin Chem23: 2258–2262, 1977.
9.
. HimmelsteinJKPattonTFBeltRJ: Clinical pharmacokinetics of intact cisplatin and some related species. Clin Pharmacol Ther29: 658–664, 1981.
10.
. HoldenerEEParkCHBeltRJ: Effect of mannitol and human plasma on cytotoxicity of cis-dichlorodiammineplatinum. Clin Res26: 4364A, 1978.
11.
. LitterstCLGramTEDedrickRLLeroyAFGuarinoAM: Distribution and disposition of platinum following intravenous administration of cis-diamminedicholoroplatinum (II) (NSC 119875) to dogs. Cancer Res36: 2340–2343, 1976.
12.
. LangeRCSpencerRPHarderHC: Synthesis and distribution of a radiolabeled antitumor agent: Cis-diamminedichloroplatinum (II). J Nuc Med13: 328–330, 1972.
13.
. Von HoffDDCasperJBradleyE: Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapy. Am J Med70: 1027–1032, 1981.
