Prostaglandins were found in the middle ear effusion and may play an important role in inflammation and bone resorption occurring in otitis media. With the use of an immunohistochemical technique, prostaglandin cyclooxygenase was localized in epithelial cells of human skin, endothelial cells of arterioles, mononuclear leukocytes and fibroblasts of human middle ear mucosa and granulation tissue, epithelial cells of chinchilla middle ear mucosa, and the external auditory canal skin.
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References
1.
. JacksonRT: Autonomic stimulation osmolarity and prostaglandin effects in eustachian tube. Ann Otol Rhinol Laryngol80: 313–318, 1971.
. JungTTKSmithDMJuhnSKGerrardJM: Prostaglandins and otitis media: Studies in the chinchilla. OTOLARYNGOL HEAD NECK SURG88: 316–323, 1980.
5.
. JungTTKJuhnSKGerrardJM: Identification of prostaglandins and other arachidonic acid metabolites in experimental otitis media. Prostaglandins Leukotrienes Med8: 249–261, 1982.
6.
. HassidAKonickowskiMDunnMJ: Prostaglandin synthesis in isolated rat kidney glomeruli. Proc Natl Acad Sci USA76: 1155–1159, 1979.
7.
. HanszenFHAHugterenDM: Histochemical localization of prostaglandin synthetase. Histochemistry27: 159–164, 1971.
8.
. SmithWLWilkinGP: Immunochemistry of prostaglandin endoperoxide-forming cyclooxygenase in rat, rabbit and guinea pig kidneys by immunofluorescence. Prostaglandins13: 873–892, 1977.
9.
. SmithWLBellTG: Immunohistochemical localization of the prostaglandin forming cyclooxygenase in renal cortex. Am J Physiol235: 451–457, 1978.
. DobrinRSKnudsonFEMichaelAF: The secretory immune system and renal disease. Clin Exp Immunol21: 318–328, 1975.
12.
. SadeJBercoE: Bone destruction in chronic otitis media. J Laryngol Otol88: 413–422, 1974.
13.
. ThomsenJJorgensenMBBretlauP: Bone resorption in chronic otitis media: A histological and ultrastructural study. II. J Laryngol Otol88: 983–992, 1974.
14.
. AbramsonMHuangC: Localization of collagenase in human middle ear cholesteatoma. Laryngoscope87: 771–791, 1977.
15.
. GantzBGMaynardJBuhrstadRMHuangCAbramsonM: Bone resorption in chronic otitis media. Ann Otol Rhinol Laryngol88: 693–700, 1979.
16.
. TashjianAHVoeklelEFLevineL: Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is PGE2. J Exp Med136: 1329–1343, 1972.
17.
. RaiszLGDietrickJWSimmonsHA: Effect of prostaglandin endoperoxides and metabolites on bone resorption in vitro. Nature267: 532–534, 1977.
