Squamous cell carcinoma commonly invades the perineural spaces of adjacent nerves; however, few cases of intracranial spread of tumor along this route have been reported. We present three cases of intracranial spread of squamous carcinoma along the mandibular branch of the trigeminal nerve. These cases illustrate the important clinical manifestations, difficulty of diagnosis, occasional unexpectedly long clinical course, and the difficulty of management of this problem.
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