In this report we describe an immunotherapy regimen used in the management of 200 ragweed-sensitive patients. All patients were treated with immunotherapy doses inversely related to the level of allergen-specific IgE as measured by the modified RAST test. The starting doses that were given were significantly higher than those used with conventional approaches.
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References
1.
Van MetreTEAdkinsonNFJrLichtensteinLM: A controlled study of the effectiveness of the Rinkel method of immunotherapy for ragweed pollen hayfever. J Allergy Clin Immunol65: 288, 1980.
2.
HirschSRKalbfleischJHGolbertTM: Rinkel method a controlled study: Second report. J Allergy Clin Immunol65: 192, 1980.
3.
FadalRBNalebuffDJ: Tools of the allergist: Old and new. Cont Ed Fam Phys37: 61, 1979.
4.
NalebuffDJFadalRGAliM: The study of IgE in the diagnosis of allergic disorders in an otolaryngology practice. Otolaryngol Head Neck Surg87: 351, 1979.
5.
NalebuffDJFadalRB: In vitro determination of initial immunotherapy dosage: A new clinical application of the radioallergosorbent test, in JohnsonF, (ed): Allergy: Including IgE in Diagnosis and Treatment. Miami, Symposia Specialists, 1979, p 105.
6.
FranklandAWAugustinR: Prophylaxis of summer hayfever and asthma: A controlled trial comparing crude grass pollen extracts with the isolated main protein component. Lancet1: 1055, 1954.
7.
Van MetreTEJrAdkinsonFJrAmodioFJ: A comparative study of the effectiveness of the Rinkel method and the current standard method of immunotherapy for ragweed pollen hay fever. J Allergy Clin Immunol66: 500, 1980.
8.
YoungSH: Use of the Modified RAST to determine initial immunotherapy dose, in FadalRGNalebuffDJ, (eds): RAST in Clinical Allergy. Miami, Symposia Specialists, 1981.
9.
KaneJWypychJReismanR: Evaluation of serum RAST titers to determine initial doses for ragweed immunotherapy (Abstract). Read before the 37th Annual Meeting of The American Academy of Allergy, San Francisco, March 7 through 11, 1981.
10.
SantrachBAParkerJLJonesLT: Diagnostic and therapeutic applications of a modified radioallergobsorbent test and comparison with the conventional radioallergosorbent test. J Allergy Clin Immunol67: 97–104, 1981.
11.
PattersonRLiebermanPIronsJS: Immunotherapy, in MiddletonEJrReedCEEllisEF, (eds): Allergy Principles and Practice. St Louis, CV Mosby Co, 1978, vol 2, pp 877–898.
12.
PattersonRSuszkoIMPruzanskyJJ: Polymerized ragweed antigen E: II. In vitro elimination studies and reactivity with IgE antibody systems. J Immunol110: 1413, 1973.
13.
GoldsteinSMuellerUWypychJ: Treatment of ragweed-sensitive patients with ragweed fraction A conjugated to D-glutamic acid: D-lysine (FA:DGL), abstract. J Allergy Clin Immunol65: 164, 1980.
