Histiocytosis X is characterized by a proliferation of cytologically benign histiocytes and occurs in a severe form (type 1) with a short course and poor prognosis and a milder form (type 2) with a protracted course and favorable prognosis. Otolaryngologists will encounter the type 2 form of the disease and must include it in the differential diagnosis of osteolytic lesions of the skull.
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References
1.
LichtensteinL: Histiocytosis X: Integration of eosinophilic granuloma of bone, ‘Letterer-Siwe disease’ and ‘Schüller-Christian disease’ as related manifestations of a single nosologic entity. Arch Pathol56: 84–100, 1953.
2.
FrisellEBjorkstenBHoligrenG: Familial occurrence of histiocytosis. Clin Genet11: 163–170, 1977.
3.
DaneshbodKKissaneJ: Idiopathic differentiated histiocytosis. Am J Clin Pathol70: 381–3891973.
4.
NewtonWHamoudiA: Histiocytosis: A histologic classification with clinical correlation. Prospect Pediatr Pathol1: 251–283, 1973.
ChisolmJ: Otorhinologic aspects of Hand-Schüller-Christian's disease. Laryngoscope64: 486–496, 1954.
7.
LichtensteinLJaffeeH: Eosinophilic granuloma of bone, with report of a case. Am J Pathol16: 594–604, 1940.
8.
SchuknechtHPerlmanH: Hand-Schüller-Christian disease and eosinophilic granuloma of the skull. Ann Otol Rhinol Laryngol57: 643–676, 1948.
9.
FalkenburgLLittletonTHuntR: Bilateral eosinophilic granulomas of the mastoid. Arch Otolaryngol70: 292–296, 1959.
10.
DingleyA: Eosinophilic granuloma of the temporal bone. J Laryngol Otol66: 285–287, 1952.
11.
MartinT: Solitary eosinophilic granuloma of the temporal bone. Laryngoscope79: 2165–2171, 1969.
12.
SweetRKornblutAHyamsV: Eosinophilic granuloma of the temporal bone. Laryngoscope89: 1545, 1979.
13.
SmithDNesbitMD'AngioG: Histiocytosis X: Role of radiation therapy in management with special reference to dose levels employed. Ther Radiol106: 419, 1973.
