Immunologic reactivity was measured in 344 patients with nasopharyngeal carcinoma (NPC), before treatment, and in 398 age-matched control subjects. The data recorded suggest that depressed cell-mediated immunity in patients with NPC is a consequence rather than a cause of the disease. In order to reduce tumor burden in patients with NPC, radiation therapy with chemotherapy or immunopotentiation or both is recommended.
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References
1.
MaisalRHOguraJH: Abnormal dinitrochlorobenzene skin sensitization: A prognostic sign of survival in head and neck squamous cell carcinoma, Laryngoscope83:2012–2019, 1973.
2.
StefaniSKermanRAbbateJ: Serial studies of immunocompetence in head and neck cancer patients undergoing radiation therapy. Am J Roentgenol126:880–886, 1976.
3.
DeeganMJCoulthardSWQualmanSJ: A correlative analysis of in vitro parameters of cellular immunity in patients with squamous cell carcinoma of the head and neck. Cancer Res37:4475–4481, 1977.
4.
RaflaSYangSJMelekaF: Changes in cell-mediated immunity in patients undergoing radiotherapy. Cancer41:1076–1086, 1978.
5.
ShanmugaratnamK: Histological typing of nasopharyngeal carcinoma, in De-TheGItoY (eds): Nasopharyngeal Carcinoma: Etiology and Control. Lyon, France, IARC, 1978, pp 3–12.
6.
HenleWHenleGHoHC: Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups. J Natl Cancer Inst44:225–231, 1970.
7.
CatalonaWJChretienPB: Abnormalities of quantitative dinitrochlorobenzene sensitization in cancer patients: Correlation with tumor stage and histology. Cancer31:353–356, 1973.
8.
HsuMMLoRJLynnTC: Cellular immunity in nasopharyngeal carcinoma. I. Relationship between purified protein derivative test and leukocyte migration test. J Formosan Med Assoc74:517–524, 1975.
9.
BöyumA: Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest21(suppl 97): 77–89, 1968.
10.
HsuMMWangKRLynnTC: Cellular immunity in nasopharyngeal carcinoma. III. Lymphocyte subpopulations and lymphocyte response to phytohemagglutinin. J Formosan Med Assoc77:549–555, 1978.
11.
PerezCAAckermanLVMillWB: Cancer of the nasopharynx: Factors influencing prognosis. Cancer24:1–17, 1969.
12.
McCoyJLJeromeLFDeanJH: Inhibition of leukocyte migration by tumor-associated antigens and soluble extracts of human breast carcinoma. J Natl Cancer Inst53:11–17, 1974.
13.
SampleWFCertnerHRJr.ChretienPB: Inhibition of phytohemagglutinin-induced in vitro lymphocyte transformation by serum from patients with carcinoma. J Natl Cancer Inst46:1291–1297, 1971.
14.
EilberFRMortonDLKetchamAS: Immunologic abnormalities in head and neck cancer. Am J Surg128:534–538, 1974.
15.
SilvermanNAAlexanderJCJr.HollinsheadAC: Correlation of tumor burden with in vitro lymphocyte reactivity and anti-bodies to herpes virus tumor-associated antigens in head and neck squamous carcinoma. Cancer37:135–140, 1976.