Prostaglandins (PG) are naturally occurring, cyclic, unsaturated fatty acids that possess a wide range of potent biologic activities. Prostaglandins have been found in human middle ear effusions and may have implications for understanding the inflammation and, possibly, the bone resorption seen in chronic otitis media. In the study presented, PGs were measured by radioimmuno-assay in middle ear effusions from experimentally induced serous and purulent otitis media in chinchillas. The ability of chinchilla middle ear mucosa to synthesize PGs from 14C-arachidonic acid was also demonstrated. The authors suggest an active role for PGs in the inflammation and the bone resorption seen in otitis media.
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References
1.
SamuelsonB: On the incorporation of oxygen in the conversion of 8, 11, 14-eisosatrienoic acid to prostaglandin E1. J Am Chem Soc87: 3011, 1965.
2.
BergstromSDanielsonHSamuelsonB: The enzymatic formation of prostaglandin E2 from arachidonic acid. Biochem Biophys Acta90: 207–210, 1964.
3.
McGiffJCTerragnoNAColinaJ: Prostaglandins and their relationships to the kallekrein-kinin systems, in PisanoJJAustenKF, (eds): Chemistry and Biology of the Kallekrein-kinin System in Health and Disease. US Government Printing Office, 1971, pp 267–274.
4.
NeedlemanP: The synthesis and function of prostaglandins in the heart. Fed Proc35: 2376, 1976.
5.
VaneJR: Inhibition of PG synthesis as a mechanism of action for aspirin-like drugs. Nature231: 232, 1971.
6.
SchuknechtHF: Pathology of the Ear. Cambridge, Harvard University Press, 1974, pp 222–237.
7.
PaparellaMMOdaMHiraideF: Pathology of sensorineural hearing loss in otitis media. Ann Otol Rhinol Laryngol81: 632, 1972.
8.
BernsteinJMOkazakTReismanRE: Prostaglandins in middle ear effusion. Arch Otolaryngol101: 257, 1976.
9.
JacksonRTWartzmanMBPickfordL: Prostaglandins in human middle ear effusions. Prostaglandins10: 365, 1975.
10.
GantzBJClanceyCAbramsonM: Decalcification factors in granulation tissue and ear canal skin, in McCabeBFSadeJAbramsonM, (eds): Cholesteatoma: First International Conference. Birmingham, Ala, Aesculapius Publishing Co, 1977, pp 167–169.
11.
SmithDMJungTKJuhnSK: Prostaglandins in experimental otitis media. Arch Otolaryngol225: 207, 1979.
12.
JuhnSKPaparellaMMKimCK: Pathogenesis of otitis media. Ann Otol Rhinol Laryngol86: 481, 1977.
13.
BrowningGGGranichMS: Surgical anatomy of the temporal bone in the chinchilla. Ann Otol Rhinol Laryngol87: 895, 1978.
14.
JuhnSKHuffJS: Biochemical characteristics of middle ear effusions. Ann Otol Rhinol Laryngol85: 110, 1976.
15.
JuhnSKHuffJSPaparellaMM: Certain oxidative and hydrolytic enzymes in the middle ear effusion in SOM. Arch Otorhinolaryngol212: 119, 1976.
16.
GerrardJMButlerAMGraffG: Prostaglandin endoperoxides promote calcium release from a platelet membrane fraction in vitro. Prostaglandins Med1: 373, 1978.
17.
NijkampFPMoncadaSWhiteHL: Diversion of prostaglandin endoperoxide metabolism by selective inhibition of thromboxane A2 biosynthesis in lung, spleen or platelets. Eur J Pharmacol44: 179, 1977.
18.
NeedlemanPRayAFerrendelliJA: Application of imidazole as a selective inhibitor of thromboxane synthetase in human platelets. Proc Natl Acad Sci USA74: 1716, 1977.
19.
PiperPVaneJ: The release of prostaglandins from lung and other tissues. Ann NY Acad Sci180: 3637, 1971.
WillisAL: Release of histamine, kirin and PGs during cararagenin-induced inflammation in the rat, in MontegazzaPHortonEW, (eds): PGs, Peptides and Amines. London, Academic Publishing Co, 1969, p 31.
22.
DennisRGWhitmireRNJacksonRT: Action of inflammatory mediators on middle ear mucosa. Arch Otolaryngol102: 420, 1976.
23.
KleinDCRaiszLG: PGs: Stimulation of bone resorption in tissue culture. Endocrinology88: 1436, 1970.
24.
TashjianAHVoelkelEFLevineL: Evidence that the bone resorption stimulating factor produced by mouse fibrosarcoma cells is PGE2. J Exp Med136: 1329, 1972.
25.
HarrisMTollerP: The pathogenesis of dental cyst. Br Med Bull31: 159, 1975.
26.
RobinsonDRTashjianAHLevineL: Prostaglandin-stimulated bone resorption by rheumatoid synovia. J Clin Invest8: 1181, 1975.
27.
SeyberthHWRaiszLGOatesJA: PGs and hyper-calcemic states. Ann Rev Med29: 23, 1978.
28.
CohenAS: Lactic dehydrogenase and transaminase activity of sinovial fluid and serum in rheumatic disease states, with a note on synovial fluid LDH isozymes. Arthritis Rheum7: 490, 1964.
29.
WallachJ: Interpretation of Diagnostic Tests. Boston, Little Brown & Co, 1974, p 206.
30.
ThomsenJBretlauPJorgensenMB: Bone resorption in chronic otitis media, in McCabeBFSadeJAbramsonM, (eds): Cholesteatoma: First International Conference. Birmingham, Ala, Aesculapius Publishing Co, 1977, pp 136–148.
31.
SadeJBenoE: Bone destruction in chronic otitis media: A histological study. J Laryngol Otol88: 413–422, 1974.
32.
AbramsonMAsarchRGLittonWB: Experimental aural cholesteatoma causing bone resorption. Ann Otol Rhinol Laryngol84: 425, 1975.
33.
BernsteinJMHansmannEWrightJ: Middle ear disease release of soluble factor(s) stimulating bone resorption, in McCabeBFSadeJAbramsonM, (eds): Cholesteatoma: First International Conference. Birmingham, Ala, Aesculapius Publishing Co, 1977, pp 152–161.
34.
BeitchBREakinsKE: The effects of prostaglandins on the intraocular pressure of the rabbit. Br J Pharmacol37: 158–167, 1969.
35.
KischerCWKeeterJS: Prostaglandin, B., embryonic skin, and the dermo-epidermal junction. J Cell Biol47: 303–310, 1970.
