The effects of loop diuretics on the endocochlear direct current (DC) potential and the effective electrical resistance of the cochlear partition were studied. The effective electrical resistance was increased, and the endocohlear DC potential was decreased. The decrease in the endocohlear DC potential must not be caused by breaks in the electrical insulation of the cochlear partition. With loop diuretics the endocochlear DC potential decreased less in guinea pigs treated with kanamycin sulfate than it did in the control group. Two interpretations of these phenomena are presented.
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References
1.
TasakiISpyropoulosCS: Stria vascularis as source of endocochlear potential. J Neurophysiol22: 149–155, 1959.
2.
SmithCA: Structure of the stria vascularis and the spiral prominence. Ann Otol Rhinol Laryngol66: 521–536, 1957.
3.
KuijpersWBontingSL: Studies on (Na+-K+) activated ATPase-localization and properties of ATPase in the inner ear of the guinea pig. Biochem Biophys Acta173: 477–485, 1969.
4.
PaloheimoSThalmannR: Influence of “loop” diuretics upon NaK-ATPase and adenylate cyclase of the stria vascularis. Arch Otorhinolaryngol217: 347–359, 1977.
5.
KuijpersWBontingSL: The cochlear potentials: The nature of the cochlear endolymphatic resting potential. Pfluegers Arch320: 359–372, 1970.
6.
JohnstoneBMSellicPM: The peripheral auditory apparatus. Q Rev Biophys5: 1–57, 1972.
7.
PrazmaJ: Electroanatomy of the lateral wall of the cochlea. Arch Otorhinolaryngol209: 1–13, 1975.
8.
FernandezCHinojosaR: Postnatal development of endocochlear potential and stria vascularis. Acta Otolaryngol78: 173–186, 1974.
9.
DillingJMNakashimaTSnowJB: Effect of ethacrynic acid on endocohlear DC potential. Arch Otolaryngol98: 183–186, 1973.
10.
BosherSKSmithCAWarrenRL: The effect of ethacrynic acid upon the cochlear endolymph and stria vascularis. Acta Otolaryngol75: 184–191, 1973.
11.
AsakumaSShidaSSuzukiM: Experimental study on the mutual relation between endocochlear DC potential and cochlear microphonics. Audiology Jpn18: 246–254, 1975.
12.
GoldbergM: Renal tubular site of action of diuretics, in FisherJWCafrunyE, (eds): Renal Pharmacology. New York, Appleton-Century-Crofts, 1971, pp 99–119.
13.
EbelH: Effect of diuretics on renal NaK-ATPase and adenyl cyclase. Naunyn-Schmiedebergs Arch Pharmacol281: 301–314, 1974.
14.
ThalmannRIseIBohneBA: Actions of loop diuretics and mercurials upon the cochlea. Acta Otolaryngol83: 221–232, 1977.
15.
KusakariJMiyoshiTKawamotoK: The effect of ethacrynic acid upon EP and its mechanism of action. Audiology Jpn18: 261–269, 1975.
16.
SellicPMJohnstoneBM: Differential effects of ouabain and ethacrynic acid on the labyrinthine potentials. Pfluegers Arch352: 339–350, 1974.
17.
KasajimaK: Electronmicroscopic study of the stria vascularis after ethacrynic acid. Jpn J Otolaryngol76: 338–346, 1973.
18.
HornKLLangleyLRGatesGA: Effect of ethacrynic acid on the stria vascularis. Arch Otolaryngol103: 539–541, 1977.
19.
KlockhoffILindblomU: Glycerol test and diuretics in Meniere's disease. Otolaryngol Clin North Am1: 541–549, 1968.
20.
FutakiTKitaharaMMorimotoM: A comparison of the furosemide and glycerol tests for Meniere's disease. Acta Otolaryngol83: 272–278, 1977.
AsakumaSSnowJBMurakamiY: Electrical resistance of the cochlear partition. Hearing Res1: 25–30, 1978.
23.
KurokawaS: Experimental study of electrical resistance of basilar membrane in guinea pig. Jpn J Otolaryngol68: 1177–1195, 1965.
24.
KonishiTKelseyESingletonGT: Negative potential in scala media during early stage of anoxia. Acta Otolaryngol64: 107–118, 1967.
25.
AsakumaSLowryLDSnowJB: Effect of kanamycin sulfate on the endocochlear DC potential of the guinea pigs. Arch Otolaryngol105: 145–148, 1979.
26.
MisrahyGASpradleyJFBeranAV: Permeability of cochlear partitions: Comparison with blood brain barrierActa Otolaryngol52: 525–535, 1960.
27.
YamamotoKNakaiY: Electronmicroscopic studies on the functions of the stria vascularis and the spiral ligament in the inner ear. Ann Otol Rhinol Laryngol73: 332–347, 1964.
28.
HisamatsuN: Changes in permeability after kanamycinPractica Otologica57: 274–285, 1964.
29.
HoshinoT: Experimental study on the possible pathways of kanamycin into the inner ear. Jpn J Otolaryngol70: 641–648, 1966.
30.
SasakiH: The early, but limited effect of kanamycin, dihydrostreptomycin or chloramphenicol upon the guinea pigs cochlea. Jpn J Otolaryngol70: 1716–1721, 1966.
31.
TakedaS: The movement of glucose and xylose in the inner ear. Practica Otologica61: 991–1019, 1968.
