Forty hamsters received weekly installations of benzopyrene into the larynx. Twenty of these also had 10% alcohol as their total liquid intake. Carcinoma of the larynx was seen in seven alcoholic vs two nonalcoholic hamsters, supporting the evidence in humans that alcohol is a factor in epidermoid carcinogenesis of the larynx.
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References
1.
ZellerZK: Cirrhosis of the liver, alcoholism and heavy smoking associated with cancer of the mouth and pharynx. Cancer20: 1015–1022, 1967.
2.
RothmanKKellerA: The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx, J Chronic Dis25:711–716, 1974.
3.
KissinBKaleyMMSuWH: Head and neck cancer in alcoholics. JAMA224:1174–1175, 1973.
4.
WynderEL: Head and neck cancer. State of the Art Conference. Laryngoscope88(suppl 8): 40–43, 50, 1976.
5.
RothmanKJ: The effect of alcohol consumption on risk of cancer of the head and neck. Laryngoscope88(suppl 8): 51–55, 1976.
6.
SchottenfeldDGanttRCWynderEL: The role of alcohol and tobacco in multiple primary cancers of the upper digestive system, larynx and lung. Prev Med3:277–293, 1974.
7.
WynderELBrossIJDayE: A study of environmental factors in cancer of the larynx. Cancer9:86–110, 1956.
8.
KrajinaZKulcarZKonic-CarneluttiV: Epidemiology of the laryngeal cancer. Laryngoscope85:1155–1161, 1975.
9.
IwamotoH: An epidemiological study of laryngeal cancer in Japan (1960-1969). Laryngoscope85:1162–1172, 1975.
10.
AtkinsonL: Some features of the epidemiology of cancer of the larynx in Australia and Papua, New Guinea. Laryngoscope85: 1173–1184, 1975.
11.
WynderEL: Toward the prevention of laryngeal cancer. Laryngoscope85:1190–1196, 1975.
12.
LowryWS: Alcoholism in cancer of the head and neck. Laryngoscope85:1275–1285, 1975.
13.
RothmanKJ: Epidemiology of head and neck cancer. Laryngoscope88:435–438, 1978.
14.
SaffiottiUCefisFKolbLH: A method for the experimental induction of bronchogenic carcinoma. Cancer Res28:104–124, 1968.
15.
ArvolaA: Comparison between water and alcohol consumption in six animal species in free choice experiments. Nature191:819–820, 1961.
16.
MontesanoRSaffiottiUShubikP: The role of topical and systemic factors in experimental respiratory carcinogenesis, in Inhalation Carcinogenesis Atomic Energy Commission Symposium Series, conference 691001. US Dept of Health, Education, and Welfare, National Institutes of Health, 1970.
17.
PalmerDL: Alcohol consumption and cellular immunocompetence: Head and neck cancer. State of the art conference. Laryngoscope88(suppl 8): 13–17, 1976.
