Iontophoresis can be used as a method of treating herpes simplex virus and aphthous gingivostomatitis. Idoxuridine has been used for herpes simplex virus, and corticosteroids and antibiotics have been used for aphthous stomatitis. Levamisole hydrochloride has been used for both herpes simplex virus and recurrent aphthous stomatitis.
A lidocaine and adrenaline mixture is used with iontophoresis for myringotomy procedures and equalizing tubes. Also, anesthesia of the skin and subcutaneous tissues with lidocaine hydrochloride by iontophoresis are useful for minor surgical procedures (“ouchless surgery”).
Get full access to this article
View all access options for this article.
References
1.
FrielAR: Notes on the treatment of sepsis by zinc ionization. Practitioner101:315–323, 1918.
2.
AlbertyRA: An introduction to electrophoresis. J Chem Educ25:426–433, 619–625, 1948.
3.
TiseliusAFlodinP: Zone of electrophoresis. Adv Protein Chem8:461–486, 1953.
4.
UhdeGI: The problem of permeability and anesthesia of the tympanic membrane. Arch Otolaryngol66:391–407, 1957.
5.
TrubatchJVan HarreveldA: Spread of iontophoretically injected ions in a tissue. J Theor Biol36:391–407, 1957.
6.
EcholsDFNorrisCHTabbHG: Anesthesia of the ear by iontophoresis of lidocaine. Arch Otolaryngol101:418–421, 1975.
7.
GreenbergMSBrightmanVJShipII: Clinical and laboratory differentiation of recurrent intraoral herpes simplex virus infections following fever. J Dent Res48:385–391, 1969.
8.
BarileMFFrancisTCGraykowskiEA: Streptococcus sanguis in the pathogenesis of recurrent aphthous stomatitis, in GuzeLB: Microbial Protoplasts, Spheroplasts and L-forms.Baltimore, Williams & Wilkins Co, 1968, pp 444–456.
9.
ShoreRNShelleyWB: Treatment of aphthous stomatitis by suppression on intralesional streptococci. Arch Dermatol109:400–402, 1974.
10.
DolinRGillFANahmiasAJ: Orogenital contact responsible for rise in HSV-1 genital infections. Infect Dis6:1, 12, 1976.
11.
SmithEB: Management of herpes simplex infections of the skin. JAMA235:1731–1733, 1976.
12.
SymoensJBrugmansJ: Treatment of recurrent aphthous stomatitis and herpes with levamisole. Br Med J4:592, 1974.
13.
Van de HeyningJ: Levamisole in the treatment of recurrent aphthous stomatitis. Laryngoscope88:522–527, 1978.
14.
GordonBKKeenanJP: The treatment of systemic lupus erythematosus (SLE) with the T-cell immunostimulant drug levamisole: A case report. Ann Allergy6:342–355, 1975.
15.
SwierengaJGooszenHCVanderschverenRG (study group for bronchogenic carcinoma): Immunopotentiation with levamisole in resectable bronchogenic carcinoma: A double-blind controlled trial. Br Med J3:461–464, 1975.
