The effects of nitrogen mustard on the electrical potentials of the inner ear were studied, and the results were correlated with the histopathologic findings which have been reported in nitrogen mustard ototoxicity. The endocochlear DC potential (EP) decreased rapidly after an injection of nitrogen mustard (NM). The amplitude of the cochlear microphonics potential (CM) diminished rapidly, and no substantial recoveries were observed. No significant changes in the magnitude of the negative potential of organ of Corti (NPOC) were observed. A large negative summating potential (SP) was recorded even when the amplitude of the CM had diminished.
NakaiYYamamotoKIwamotoT: Ototoxic effects of nitrogen mustard N-oxide, gentamycin and ethacrynic acid and some congenital deaf animal cochlea. Audiology Jpn14: 504–512, 1971.
8.
NakamuraSKatanoAKikuchiK: Ultrastructure of the cochlear hair cells in guinea pig after injection of nitrogen mustard N-oxide. Audiology Jpn14: 513–518, 1971.
9.
GilmanAPhilipsFS: The biological actions and therapeutic applications of the β-chloroethyl amines and sulfides. Science103: 409–415, 1946.
10.
GraefeIKarnofskyDAJagerVB: The clinical and pathological effects of the nitrogen and sulfur mustards in laboratory animals. Am J Pathol24: 1–47, 1948.
11.
McDonaldTPAsanoM: Effects of nitrogen mustard on the mouse brain. Am J Pathol38: 695–708, 1961.
IshidateMKobayashiKSakuraiY: Experimental studies of chemotherapy of malignant growth employing Yoshida sarcoma animals: II. The effect of N-oxide derivatives of nitrogen mustard. Proc Jpn Acad27: 493–500, 1951.
14.
GoldinANoeHALandingBH: A neurological syndrome induced by administration of some chlorinated tertiary amines. J Pharmacol Exp Ther94: 249–261, 1948.
15.
Von BekesyG: DC resting potentials inside the cochlear partition. J Acoust Soc Am24: 72–76, 1952.
16.
TasakiISpyropoulosCS: Stria vascularis as source of endocochlear potential. J Neurophysiol22: 149–155, 1959.
17.
AsakumaSShidaSSuzukiM: Experimental study on the mutual relation between endocochlear DC potential and cochlear microphonics. Audiology Jpn18: 246–254, 1975.
18.
GotoT: Experimental studies on the negative intracellular potential of the organ of Corti under various conditions. J Otolaryngol Jpn76: 82–107, 1973.
19.
SohmerHSPeakeWTWeissTF: Intracochlear potential recorded with micropipets: I. Correlations with micropipet location. J Acoust Soc Am50: 572–586, 1971.
20.
DavisHDeatherageBHRosenliutB: Modification of cochlear potentials produced by streptomycin poisoning and by extensive venous obstruction. Laryngoscope68: 596–627, 1958.
21.
ImaiI: Experimental studies on the relationship of the electrical phenomenon in inner ear. J Otolaryngol Jpn71: 100–123, 1968.
