Difficulty in assessment of potentiating interaction between noise-induced and kanamycin-induced injury to hearing is compounded by the great variability of intersubject response to the same drug dosage. However, in a given subject, response of the two cochleas to kanamycin intoxication may reasonably be assumed to be symmetric. The present study was designed to utilize this similarity, in determining whether kanamycin intoxication would potentiate a normally subtraumatic noise stimulus. Under the experimental conditions outlined, it was found that after a dosage of 150 mg/kg/day of kanamycin given to a physiologic end point, normally subtraumatic noise caused consistent increase in hearing loss.
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2.
DayalVSKokshanianAMitchellDP: Combined effects of noise and kanamycin. Ann Otol Rhinol Laryngol80:897–902, 1971.
3.
HawkinsJEMarquesDMClarkCS: Noise and kanamycin interaction in the guinea pig cochlea. J Acoust Soc Am57:S60, 1975.
4.
MarquesDMClarkCSHawkinsJE: Potentiation of cochlear injury by noise and ototoxic antibiotics in guinea pigs, j Acoust Soc Am57:S1, 1975.
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MillerD: Audibility curve of the chinchilla. J Acoust Soc Am48:513–523, 1970.
6.
RyanABoneRC: Noise-induced threshold shift and cochlear pathology in the mongolian gerbil. J Acoust Soc Am, to be published.
7.
RyanADallosP: Effect of absence of cochlear outer hair cells on behavioral auditory threshold. Nature253:44–46, 1975.
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SpoendlinHBrunJP: Block surface technique for evaluation of cochlear pathology. Arch Otorhinolaryngol208:137–145, 1974.
9.
BohneB: Scar formation in the inner ear following acoustical injury: Sequence of changes from early signs of damage to healed lesion. Thesis, University of Washington, Seattle, St Louis, 1971.
