The growth and shape of the membraneous labyrinth appears to be organized and restricted by the formation of the cartilaginous capsule. Coiling of the cochlear duct appears to be the result of the physical barrier and support provided by the cartilage cells differentiating from mesenchyme surrounding the otocyst. In addition, tissue interactions between this mesenchyme and the developing cochlear duct may be the source of a genetic message for the coiling mechanism.
LewisWH: On the origin and differentiation of the otic vesicle in amphibian embryos. Anat Rec1: 142–145, 1906.
2.
EisingerKSternbergH: Beiträge zur Entwicklungsmechanik des inneren Ohres. Arch Entw dBd 100: 542–559, 1924.
3.
LutherA: Entwicklunsmechaniscle Untersuchungen am Labyrinth einiger Anuren. Soc Sci Fenn, Comm Biol2: 1–48, 1924.
4.
SternbergH: Über Transplantation des Ohrbläschens bei Forschiarven. Arch Entw dBd 103, 1924.
5.
KaanWH: The relation of the developing auditory vesicle to the formation of the cartilage capsule in Amblystoma punctatum. J Exp Zool55: 263–291, 1930.
6.
KaanWH: Further studies on auditory vesicle from cartilaginous capsule of Amblystoma punctatum. J Exp Zool78: 169–183, 1938.
7.
RubenRJ: Development of the inner ear of the mouse. A radioautographic study of terminal mitosis. Acta Otolaryngol (Suppl), 220, 1967.
8.
LiCWVan De WaterTRRubenRJ: In vitro study of fate mapping of mouse otocyst. Trans Am Acad Ophthalmol Otolaryngol82: ORL-273–ORL-280, 1976.
9.
WaddingtonCW: The determination of the auditory placode in the chick. J Exp Biol14: 232–239, 1937.
10.
YntemaCL: An analysis of induction of the ear from foreign ectoderm in the salamander embryo. J Exp Zool113: 211, 1950.
11.
ZwillingE: The determination of the otic vesicle in rana pipen. J Exp Zool86: 333–342, 1941.
