Role of Obesity on the Prognosis of Sudden Sensorineural Hearing Loss in Adults

Abstract

Objective

To investigate the role of obesity/overweight on the prognosis of sudden sensorineural hearing loss (SSHL).

Study Design

Retrospective cohort study.

Setting

Outpatient department of a community hospital.

Subjects and Methods

We collected 254 adult patients with SSHL from a community hospital. The odd ratios of body mass index (BMI) or obesity/overweight (BMI ≥25 kg/m²) on the recovery of SSHL were evaluated with multivariate logistic regression analysis.

Results

There were 120 (47.2%) patients in the nonobesity group (BMI <25 kg/m²) and 134 (52.8%) patients in the obesity/overweight group (BMI ≥25 kg/m²). The complete and partial recovery rates were 10.0% and 49.2% in the nonobesity group and 9.7% and 47.0% in the obesity/overweight group, respectively. Univariate logistic regression showed that BMI had no significant association with recovery of SSHL (odds ratio [OR] of complete and partial recovery versus no recovery = 1.04, 95% confidence interval [CI] = 0.965-1.113, P = .327). Multivariate logistic regression analysis also showed that BMI (OR = 1.04, 95% CI = 0.964-1.131, P = .292) was not significantly associated with the recovery of SSHL for all subjects, after adjusting for all considered variables. Also, obesity/overweight (BMI ≥25 kg/m²) had no significant association with the recovery of SSHL.

Conclusion

Obesity/overweight would appear to have no significant effect on the prognosis of SSHL.

Keywords

Body mass index obesity overweight sudden sensorineural hearing loss prognosis auditory function

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References

Byl

. Sudden hearing loss: eight years experience and suggested prognostic table. Laryngoscope. 1984;94:647-661.

Greco

Fusconi

Gallo

Marinelli

Macri

De Vincentiis

. Sudden sensorineural hearing loss: an autoimmune disease? Autoimmun Rev. 2011;10:756-761.

Hughes

Freedman

Haberkamp

Guay

. Sudden sensorineural hearing loss. Otolaryngol Clin North Am. 1996;29:393-405.

Chau

Lin

Atashband

Irvine

Westerberg

. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120:1011-1021.

Aimoni

Bianchini

Borin

. Diabetes, cardiovascular risk factors and idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol. 2010;15:111-115.

Lin

Hsu

Lin

Weng

. Increased risk of getting sudden sensorineural hearing loss in patients with chronic kidney disease: a population-based cohort study. Laryngoscope. 2013;123:767-773.

Chu

Liu

Fuh

Shiao

Chen

Wang

. Migraine is a risk factor for sudden sensorineural hearing loss: a nationwide population-based study. Cephalalgia. 2013;33:80-86.

Fransen

Topsakal

Hendrickx

. Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: a European population based multicenter Study. J Assoc Res Otolaryngol. 2008;9:264-276.

Hwang

Hsu

Liu

Yang

. Association of central obesity with the severity and audiometric configurations of age-related hearing impairment. Obesity. 2009;17:1796-1801.

10.

Hwang

Chen

Yang

Liu

. Waist circumference is associated with pitch pattern sequence score in older male adults. Int J Audiol. 2012;51:920-925.

11.

Ness-Abramof

Apovian

. Waist circumference measurement in clinical practice. Nutr. Clin Pract. 2008;23:397-404.

12.

Nakashima

Yanagita

. Outcome of sudden deafness with and without vertigo. Laryngoscope. 1993;103:1145-1149.

13.

Hirano

Ikeda

Kawase

. Prognosis of sudden deafness with special reference to risk factors of microvascular pathology. Auris Nasus Larynx. 1999;26:111-115.

14.

Nagaoka

Anjos

Takata

. Idiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias. Braz J Otorhinolaryngol. 2010;76:363-369.

15.

Shikowitz

. Sudden sensorineural hearing loss. Med Clin North Am. 1991;75:1239-1250.

16.

Wang

Hou

Liu

. Clinical analysis of sudden sensorineural hearing loss in patients with different ages [in Chinese]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013;48:385-388.

17.

Nosrati-Zarenoe

Hultcrantz

. Corticosteroid treatment of idiopathic sudden sensorineural hearing loss: randomized triple-blind placebo-controlled trial. Otol Neurotol. 2012;33:523-531.

18.

Ulu

Bucak

Ahsen

Yucedag

Aycicek

. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2013;34:1400-1404.

19.

Ziegler

Hohlweg-Majert

Maurer

Mann

. Epidemiological data of patients with sudden hearing loss: a retrospective study over a period of three years [in German]. Laryngorhinootologie. 2003;82:4-8.

20.

Mosnier

Stepanian

Baron

. Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol. 2011;16:55-66.

21.

Lionello

Staffieri

Breda

. Uni- and multivariate models for investigating potential prognostic factors in idiopathic sudden sensorineural hearing loss [published online March 25, 2014]. Eur Arch Otorhinolaryngol.

22.

Yasan

Tüz

Yariktaş

Aynali

Tomruk

Akkuş

. The significance of routine laboratory parameters in patients with sudden sensorineural hearing loss. Indian J Otolaryngol Head Neck Surg. 2013;65(suppl 3):553-556.

23.

Stachler

Chandrasekhar

Archer

. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg. 2012;146:S1.

24.

Weiss

Neuner

Gorzelniak

Bremer

Redack

Walter

. Platelet glycoproteins and fibrinogen in the recovery from idiopathic sudden hearing loss. PLoS One. 2014;9:e86898.

25.

Ahima

. Adipose tissue as an endocrine organ. Obesity. 2006;14(suppl 5):242-249.

26.

Maia

Campos

. Diabetes mellitus as etiological factor of hearing loss. Rev Braz J Otorhinolaryngol. 2005;71:208-214.

27.

Schaffer

. Lipotoxicity: when tissue overeat. Curr Opin Lipidol. 2003;14:281-287.

28.

Hwang

Hsu

Liu

Yang

. Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice. PLoS One. 2013;8:e60730.

29.

Hwang

Hsu

Liu

Yang

. Adiponectin beyond cardiometabolic disorders. J Formosan Med Assoc. 2011;110:796-797.

30.

Hwang

Hsu

Liu

Yang

. Association of plasma adiponectin levels with hearing thresholds in adults. Clin Endocrinol (Oxf). 2011;75:614-620.

31.

Lim

Kim

Choi

. Efficacy of 3 different steroid treatments for sudden sensorineural hearing loss: a prospective, randomized trial. Otolaryngol Head Neck Surg. 2013;148:121-127.

32.

Bae

Noh

Jun

. Efficacy of intratympanic steroid therapy for idiopathic sudden sensorineural hearing loss: comparison with systemic steroid therapy and combined therapy. Acta Otolaryngol. 2013;133:428-433.