Abstract
Objectives:
Evaluate the effectiveness and biocompability of propylene mesh in an animal model of nasal septal perforations on rabbits.
Methods:
A nasal septal perforation model was created on rabbits, then nasal septal perforations were closed via 2 different methods with open rhinoplasty technique. Some perforations were closed with mucosal flaps and propylene mesh as interpositional graft. The others were repaired with bilateral mucosal flaps. After 4 weeks, nasal septums were totally removed and histopathological evaluation was done for acute rejection, infection, inflammatory response, fibrosis, and granuloma formation.
Results:
No septal perforation was repaired in the mucosal flap-only group. In the second group, all perforations were repaired completely. Of 5 samples of study group, 1 showed +1 (62.5%) inflammatory response, 1 (12.5%) sample showed +2 and 2 samples showed +3 (25%), respectively. A total of 3 (37.5 %) samples of group 2 did not show any fibrosis, 4 (50%) samples showed mild fibrosis, and 1 (12.5%) sample showed moderate fibrosis. A total of 7 (87.5%) samples showed mild fibrosis at most. We did not see any severe fibrosis at all. We observed 6 (75%) samples that showed no granuloma formation as foreign body reaction and 2 (25%) samples showed few giant cells. Heavy vascular and epithelial proliferation was seen along borders of propylene mesh.
Conclusions:
Propylene mesh showed good biocompability with septal mucosa and can be used for repair of septal perforation as interpositional graft safely.
Get full access to this article
View all access options for this article.