Abstract
Objective: 1) To determine the effectiveness of triamcinolone-soaked middle-meatal-spacers (MMS) within a perforated surgical gloved finger on improving healing and reducing inflammation in CRS patients post-FESS.
2) To determine if triamcinolone-soaked MMS within a perforated surgical gloved finger improves patient reported outcomes post-FESS.
Methods: Double-blind randomized controlled trial of 50 CRS patients undergoing FESS. Patients receive MMS in perforated glove fingers bilaterally, impregnated with triamcinolone (experimental arm) or saline (control). Primary outcome measure is the validated Philpott-Javer endoscopic mucosal inflammation scoring system at postoperative days 14, 28, and 3, 6 months. SNOT-22 scores were secondary outcomes.
Results: Our interim results, based on 36 participants, are optimistic. Patients in the triamcinolone group show clinically significant improvement in Philpott-Javer endoscopic scores compared to saline controls at 28 days postoperative examination, however this difference was not currently statistically significant (1.185 vs 2.65; P = .084). There was no significant difference between SNOT-22 scores for the 2 groups at postoperative day 28 (P = .88).
Conclusion: Triamcinolone-impregnated MMS may improve postoperative inflammation and healing in CRS patients following FESS.
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