Abstract
Objective: We proposed that chronic rhinosinusitis (CRS) is classified by 4 phenotypes in the previous study. Three phenotypes in the 4 were well classified by nasal polyps and mucosal eosinophil count. In this study we investigated the difference of recurrence rate of nasal polyps after endoscopic sinus surgery between these three phenotypes.
Method: This study was a prospective collecting data and retrospective analysis. All patients were followed up for at least 180 days after endoscopic sinus surgery. We defined mucosal eosinophilia as over 80 eosinophils under high-power magnification. Disease-free survival curves were drawn using the Kaplan-Meier method and compared using log-rank test.
Results: A total of 264 of the 375 patients were enrolled in the study. The mean follow-up period was 540.4 days. Polyp recurrence was significantly different between the 3 groups (P = .016). Patients with cluster 4 (eosinophilic CRSwNP) had a higher polyp recurrence rate than cluster 2 (non-eosinophilic CRSwNP; P = .047) and cluster 1 (non-eosinophilic CRSsNP; P = .005). Cluster 1 and cluster 2 had no significant difference (P = .362).
Conclusion: We demonstrated polyp recurrence rate was different between the three phenotypes.
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