Abstract
Objective: Little is known about the mechanism that causes tinnitus and there is no definite treatment. In practice, a combination of drugs is preferred over a single drug regimen. The aim of this study is to evaluate and compare the effectiveness of 3 kinds of combination regimen for tinnitus.
Method: We reviewed the records of 128 patients (157 ears) with tinnitus. Fifty of these patients were treated with ginkgo biloba extract, antiplatelets and anxiolytics. Another 50 patients were treated with ginkgo biloba extract, anxiolytics, and vasodilator. Twenty-eight patients were treated with anxiolytics and vasodilator. Pre- and posttreatment statuses were analyzed by tinnitus handicap inventories.
Results: Subjective tinnitus was improved in all 3 groups with no significant difference in tinnitus handicap inventory scores between the 3 observed groups (P = .2). The response group had a tendency to have longer periods of medication intake and lower Beck Depression Index scores compared to the nonresponse group. There was no difference between the response group and the nonresponse group in age, sex, or tinnitus characteristics.
Conclusion: From the analysis of this study, combined medical therapy is effective for tinnitus regardless of regimen.
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