Abstract
Objective: DISE is increasingly being used to localize the obstructive site in OSAS patients. The objective of this study is to determine if propofol changes sleep parameters in polysomnography.
Method: Thirty subjects (6 controls/24 with OSAS) underwent 2 diurnal polysomnographies, with/without the use of propofol, controlled by target-controlled infusion pump (Diprifusor). The examinations were compared regarding the presence of snoring, AHI, oxygen desaturation, and sleep architecture. Endoscopies with the patients sleeping and awake were also compared.
Results: The use of propofol did not induce snoring in the control subjects, whereas 100% of the OSAS patients snored. Propofol increased N3 sleep and abolished totally REM sleep (P2 did not differ significantly between the 2 examinations (P > .05). The minimum SaO2 were significantly reduced during propofol sedation.
Conclusion: Propofol changed the sleep architecture, but not the main respiratory parameters in OSAS. DISE was shown to be safe and more reliable to determine the sites of obstruction, supporting the view that this examinations is promising for the management of this disease.
Get full access to this article
View all access options for this article.