Abstract
Objective: Identify the effect of RSV on upper respiratory tract infections or the symptoms of allergic rhinitis by investigating the changes of the aspect of the expressions of many chemokines or the histamine receptor when the epithelial cells of the nasal mucosa or the fibroblast are infected by RSV.
Method: A mucosa sample of the inferior turbinate is obtained from 12 patients. One half of the sample is used for incubation of epithelial cells, and the other half is used in culturing fibroblasts. After infecting the cultured samples by RSV, we check the expression of Eotaxin, RANTES, IL-8, GRO-a, and HRc.
Results: The study suggests that as time passes by after RSV infection, upper respiratory tract epithelial cell samples show an increase of H1RC, H2RC, H4RC, RANTES, and IL-8, and fibroblast samples show an increase of expression of H1RC, H2RC, H3RC, H4RC, GRO-a, and IL-8.
Conclusion: The epithelial cells of the human upper respiratory tract, similar to those of the human lower respiratory tract, cause an influx of variable inflammatory cells and, therefore, induce inflammatory response and hyperreactivity, cause increased expression of histamine receptors, and induce symptoms similar to those of allergic rhinitis, such as rhinorrhea and sneezing.
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