Abstract
Objective: NBI (Narrow Band Imaging) helps to visualize subtle changes in microvascular architecture linked to neoangiogenesis. Combination of NBI with HDTV (high-definition television) and magnifying endoscopy provides best sensitivity and specificity. The most frequent false positive results were reported in laryngeal papillomatosis where the micro-vascular pattern could be misinterpreted as neoplastic.
Method: Patients with clinical diagnosis of papillomatosis or laryngeal cancer were included in the study. NBI HDTV camera head was used in combination with rigid magnifying telescope during microlaryngoscopy. Type and extent of micro-vascular mucosal changes were recorded. Mucosal lesions were removed radically and histologically evaluated and correlated with clinical findings.
Results: Preliminary results show that increased neoangiogenesis is present in both laryngeal papillomatosis and laryngeal SCC. The presence of prolonged and enlarged capillary loops was observed in both groups. This yields difficulties in differentiation between both entities.
Conclusion: The discrimination of papillomatosis and early stage of laryngeal SCC is difficult even when NBI HDTV magnifying endoscopy is used. Creation of special classification of capillary loop changes in laryngeal mucosa is needed.
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